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                <text>Ramezan Jafari, Houshyar Maghsoudi, Amin Saburi</text>
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                <text>Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials</text>
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                <text>Rami  A. Al-Horani, Srabani Kar, Kholoud  F. Aliter</text>
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                <text>The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present significant challenges to the health care systems around the world. This is primarily because of the lack of vaccines to protect against the infection and the lack of highly effective therapeutics to prevent and/or treat the illness. Nevertheless, researchers have swiftly responded to the pandemic by advancing old and new potential therapeutics into clinical trials. In this review, we summarize potential anti-COVID-19 therapeutics that block the early stage of the viral life cycle. The review presents the structures, mechanisms, and reported results of clinical trials of potential therapeutics that have been listed in clinicaltrials.gov. Given the fact that some of these therapeutics are multi-acting molecules, other relevant mechanisms will also be described. The reviewed therapeutics include small molecules and macromolecules of sulfated polysaccharides, polypeptides, and monoclonal antibodies. The potential therapeutics target viral and/or host proteins or processes that facilitate the early stage of the viral infection. Frequent targets are the viral spike protein, the host angiotensin converting enzyme 2, the host transmembrane protease serine 2, and clathrin-mediated endocytosis process. Overall, the review aims at presenting update-to-date details, so as to enhance awareness of potential therapeutics, and thus, to catalyze their appropriate use in combating the pandemic.</text>
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                <text>Las colonias francesas dentro de la ecología-mundo (1830-1962): el caso de los combustibles fósiles, los bosques y las plantaciones tropicales en Argelia y Vietnam</text>
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                <text>Los imperios coloniales jugaron un papel importante en la historia del Capitaloceno a través de la apropiación y explotación de los recursos naturales baratos, de la mano de obra y las energías baratas del mundo extraeuropeo, pero también por su producción de las naturalezas capitalizadas dentro de él, y, más ampliamente su coproducción de un mundo ecológico caracterizado por intercambios económicos y ecológicos desiguales a escala global. Basado en una problemática resultante del trabajo de Jason Moore, una reinterpretación de la historiografía existente y un trabajo de archivo, este artículo muestra que, si bien es esclarecedor comprender la historia de los combustibles fósiles, los bosques y las plantaciones de Argelia (1830-1962) y de Vietnam (1858-1954) en términos de ecología-mundo, su contribución al desarrollo de la ecología-mundo debe examinarse a la luz de las especificidades de cada colonia y de cada sector.   En primer lugar, hay que matizar la hipótesis de una producción colonial de combustibles fósiles que sería sistemáticamente barata y destinada a los centros capitalistas occidentales de la ecología-mundo, no correspondiendo esta hipótesis ni al carbón argelino (caro y usado localmente) ni a los hidrocarburos argelinos (caros y exportados principalmente a Francia) ni al carbón vietnamita (barato pero exportado al sudeste asiático). Entonces, la historia conjunta de las plantaciones de caucho vietnamitas y la agricultura colonial argelina revela una capacidad desigual y nunca absoluta de los colonizadores franceses, siempre dependientes de las condiciones ecológicas locales, para crear naturalezas capitalizadas que generen productos tropicales baratos. Finalmente, el estudio combinado de la explotación colonial de los recursos forestales en Argelia y Vietnam permite mostrar hasta qué punto el ecologismo manifestado por los colonizadores franceses, en particular el de las administraciones forestales coloniales, no obstaculizó la producción. Para la ecología-mundo, este análisis, evidentemente, merecería ser profundizado por nuevos estudios de caso, pero constituye, sin embargo, un primer vistazo a la compleja inserción histórica de las colonias francesas en el mundo ecológico.</text>
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                <text>Colonialismo, HISTORIA, capitaloceno, ecología-mundo, imperio colonial francés</text>
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                <text>10.15366/relacionesinternacionales2021.46.004</text>
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                <text>Universidad Autónoma de Madrid.</text>
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                <text>Political science, International relations</text>
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                <text>&lt;a href="https://revistas.uam.es/relacionesinternacionales/article/view/12756" target="_blank" rel="noreferrer noopener"&gt;https://revistas.uam.es/relacionesinternacionales/article/view/12756&lt;/a&gt;</text>
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                <text>De la eco-historia a la ecología-mundo</text>
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                <text>Rami ZAHRAWI HAJ-YOUNES, Jean-Paul Deléage, Daniel Hémery</text>
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                <text>Desde tiempos prehistóricos, las actividades humanas han transformado los ecosistemas. Pero es con la llegada del capitalismo industrial se ha traspasado un umbral histórico. A finales del siglo XX, la constitución de un espacio mundo productivo es el estandarte de la unificación ecológica del mundo: de la destrucción acelerada de especies, de la contaminación de los océanos, del agujero en la capa de ozono atmosférica amenazan hoy al planeta. En el Tercer Mundo, las tensiones ambientales son viejas conocidas, como la deforestación y la desertificación. Llevándolos al umbral de una economía-mundo, el capitalismo, tanto en sus versiones clásicas como en sus avatares socialistas" ha empujado a las sociedades a una nueva relación con la naturaleza: la de un mundo ecológico."</text>
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                <text>Universidad Autónoma de Madrid.</text>
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                <text>Political science, International relations</text>
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                <text>&lt;a href="https://revistas.uam.es/relacionesinternacionales/article/view/13651" target="_blank" rel="noreferrer noopener"&gt;https://revistas.uam.es/relacionesinternacionales/article/view/13651&lt;/a&gt;</text>
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                <text>Rami Zurayk</text>
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                <text>First paragraphs:  “The old world is dying, and the new world struggles to be born: now is the time of monsters.”  —Antonio Gramsci  Like many modern day viral epidemics (e.g., MERS, SARS), SARS-CoV-2 emerged from the folds of the food system. The dominant narrative puts its earliest appearance in the wet market of the Chinese city of Wuhan, where wild animals are also traded. However, there are indications that SARS-CoV-2, which is responsible for the COVID-19 pandemic, may have developed in intensive livestock farming systems, possibly pig farming (GRAIN, 2020).  Not only did the virus originate from the food system, but it also penetrated it and exposed its sys­temic weaknesses. The disruptions caused by the COVID-19 pandemic are now threatening the food security of billions of people. Indeed, after initial reassurances that COVID-19 posed no concerns to global food security, as the world’s silos were well stocked (Vos, Martin, &amp; Laborde, 2020), the tone has now changed radically. We are now being warned that global hunger could double due to food supply disruptions caused by the pandemic, especially in poor nations and in Africa (De Sousa, 2020). . . .</text>
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                <text>Pandemic, COVID-19, global South, Public Health, food security, Hunger</text>
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                <text>DOI: 10.5304/jafscd.2020.093.014</text>
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                <text>Thomas A. Lyson Center for Civic Agriculture and Food Systems</text>
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                <text>Technology, Environmental sciences, Geography. Anthropology. Recreation, Human ecology. Anthropogeography, Social Sciences, Agriculture, Communities. Classes. Races, Recreation. Leisure, Nutrition. Foods and food supply, Urban groups. The city. Urban sociology, Regional planning, Home economics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study.</text>
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                <text>Ramin Sami, Forogh Soltaninejad, Babak Amra, Zohre Naderi, Shaghayegh Haghjooy Javanmard, Bijan Iraj, Somayeh Haji Ahmadi, Azin Shayganfar, Mehrnegar Dehghan, Nilufar Khademi, Nastaran Sadat Hosseini, Mojgan Mortazavi, Marjan Mansourian, Miquel Angel Mañanas, Hamid Reza Marateb, Peyman Adibi</text>
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                <text>The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need for immediate targeted actions. We designed a longitudinal study in a hot outbreak zone to analyze the serial findings between infected patients for detecting temporal changes from February 2020. In a hospital-based open-cohort study, patients are followed from admission until one year from their discharge (the 1st, 4th, 12th weeks, and the first year). The patient recruitment phase finished at the end of August 2020, and the follow-up continues by the end of August 2021. The measurements included demographic, socio-economics, symptoms, health service diagnosis and treatment, contact history, and psychological variables. The signs improvement, death, length of stay in hospital were considered primary, and impaired pulmonary function and psychotic disorders were considered main secondary outcomes. Moreover, clinical symptoms and respiratory functions are being determined in such follow-ups. Among the first 600 COVID-19 cases, 490 patients with complete information (39% female; the average age of 57±15 years) were analyzed. Seven percent of these patients died. The three main leading causes of admission were: fever (77%), dry cough (73%), and fatigue (69%). The most prevalent comorbidities between COVID-19 patients were hypertension (35%), diabetes (28%), and ischemic heart disease (14%). The percentage of primary composite endpoints (PCEP), defined as death, the use of mechanical ventilation, or admission to an intensive care unit was 18%. The Cox Proportional-Hazards Model for PCEP indicated the following significant risk factors: Oxygen saturation &lt; 80% (HR = 6.3; [CI 95%: 2.5,15.5]), lymphopenia (HR = 3.5; [CI 95%: 2.2,5.5]), Oxygen saturation 80%-90% (HR = 2.5; [CI 95%: 1.1,5.8]), and thrombocytopenia (HR = 1.6; [CI 95%: 1.1,2.5]). This long-term prospective Cohort may support healthcare professionals in the management of resources following this pandemic.</text>
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                <text>2020</text>
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                <text>10.1371/journal.pone.0241537</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Science, Medicine</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Effect of four tillage methods on the physical properties and loss of soil in the potatoâ€“grass rotation in hillside areas of a high Andean region in Colombia Efecto de cuatro métodos de labranza sobre las propiedades físicas y la pérdida de suelo en la rotación papaâ€“pastos en áreas de ladera en una región alto andina de Colombia</text>
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                <text>Ramírez Luís, Chaparro Anaya Oscar, Bernal Napoleón, Ipaz Sandro, Montealegre Guillermo</text>
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                <text>&amp;lt;span style='font-size: 10pt; font-family: Arial'&amp;gt;This study evaluated the loss and the changes in the soil physical properties, and the production of yellow potato &amp;lt;em&amp;gt;Solanum phureja&amp;lt;/em&amp;gt;, as a result of four tillage systems (Human traction, THT; Animal traction, ATT; Mechanical, MT; and Mechanical combined, CMT) in Santa Lucia, Tuluá municipality, high andean region of Colombia to 2.870 masl. Treatments were evaluated using a completely randomized blocks desing with three replicates, and the data examined by means of a matrix of change for each physical property. Soil loss was determined by the ditch of runoff. Mechanical traction affected the soil physical properties negatively, that became evident in the increment of losses with the runoff. The bigger loss of soil was correlated with MT use and it diminished to the 50 % with HTT: (MT 6.12 tha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; year&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt;; CMT 5.0 tha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; year&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt;; ATT 3.7 tha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; year&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; and HTT 2.73 tha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; year&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt;). ATT generated the bigger cost–reducing and environmental retribution, because his production (13 tha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt;) was major than the average obtained in the treatments (12.4 tha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt;) and the lost one belonging to ground was minor than the generated for MT and CMT.&amp;lt;/span&amp;gt;&amp;lt;span style='font-size: 10pt; font-family: Arial'&amp;gt;Este estudio avaluó la pérdida y los cambios en las propiedades físicas del suelo y la producción de papa amarilla &amp;lt;em&amp;gt;Solanum phureja&amp;lt;/em&amp;gt;, como resultado de cuatro sistemas de labranza (Tracción humana, LTH; Tracción animal, LTA; Mecánica, LM; y Mecánica combinada, LMC) en Santa Lucía, municipio de Tuluá, región alto andina de Colombia a 2.870 msnm. Los tratamientos se evaluaron usando un diseño de bloques completos al azar con tres repeticiones. La pérdida de suelo se determinó por medio de canaletas de escorrentía. La información se analizó por medio de una matriz de cambio para cada propiedad física. La tracción mecánica afectó negativamente las propiedades físicas del suelo, lo que se evidenció en el incremento de pérdidas por escorrentía. La mayor pérdida de suelo se asoció con el uso de LM y disminuyó hasta el 50% con LTH: (LM 6.12 t ha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; año&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt;; LMC 5.0 t ha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; año&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt;; LTA 3.7 t ha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; año&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; and LTH 2.73 t ha&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt; año&amp;lt;sup&amp;gt;–1&amp;lt;/sup&amp;gt;). LTA generó la mayor retribución económica y ambiental, porque su producción (13 t/ha) fue mayor que el promedio obtenido en los tratamientos (12.4 t/ha) y la pérdida de suelo fue menor que la generada por LM y LMC.&amp;lt;/span&amp;gt;</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2008</text>
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            <description>The topic of the resource</description>
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                <text>High Andean region, Hillsides soils, Métodos de labranza, Región Alto Andina, Tillage methods, erosion, grassesâ€“yellowâ€“potato Solanum phureja rotation, rotación papaâ€“pasto, soil loss, soil physical properties, suelos de laderas</text>
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                <text>Acta Agronómica</text>
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                <text>Universidad Nacional de Colombia</text>
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                <text>Agriculture</text>
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                <text>&lt;a href="http://revistas.unal.edu.co/index.php/acta_agronomica/article/view/1053" target="_blank" rel="noreferrer noopener"&gt;http://revistas.unal.edu.co/index.php/acta_agronomica/article/view/1053&lt;/a&gt;</text>
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                <text>Respuesta del lulo La Selva (Solanum quitoense x Solanum hirtum) a la aplicación de fermentados aeróbicos tipo bocashi y fertilizante químico</text>
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                <text>Ramírez-Builes Víctor Hugo, Duque Nora Naidu</text>
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            <description>An account of the resource</description>
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                <text>En un suelo derivado de cenizas volcánicas bien drenado y de alta fertilidad del municipio Ansermanuevo (zona cafetera de Colombia), en el cultivo de lulo (&amp;lt;em&amp;gt;Solanum quitoense&amp;lt;/em&amp;gt; x &amp;lt;em&amp;gt;S. hirtum&amp;lt;/em&amp;gt;) se evaluaron tres fuentes orgánicas tipo bocashi, provenientes de los procesos de fermentación de pulpa de café, lombricompuesto y gallinaza y un tratamiento con fertilizante químico (10-30-10) más un testigo absoluto sin aplicación de fertilizantes. Se empleó un diseño experimental en bloques completos al azar con tres repeticiones, cada repetición estuvo constituida por 58 plantas. Las aplicaciones de materiales orgánicos mejoraron las características del suelo, estabilizando el pH, aumentando la capacidad de intercambio catiónico y la materia orgánica. En términos generales, el tratamiento de mejor desempeño fue el bocashi de gallinaza, con un promedio de cuajamiento de fruto de 38.3% y un mayor rendimiento (4.7 t/ha). Los bocashis de lombricompuesto y pulpa de café no fueron estadísticamente diferentes al tratamiento químico y todos los tratamientos fueron distintos (P &amp;lt; 0.05) al testigo, lo que demuestra la buena respuesta del cultivo de lulo a las aplicaciones de fuentes orgánicas.</text>
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                <text>2010</text>
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            <name>Subject</name>
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                <text>Lulo, Productividad, Productivité, Solanum Quitoense, Solanum hirtum, abonos compuestos, abonos orgánicos, compound fertilizers, fertilidad del suelo, lulo crop, organic fertilizers, soil fertility changes</text>
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                <text>Acta Agronómica</text>
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            <name>Publisher</name>
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                <text>Universidad Nacional de Colombia</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Agriculture</text>
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                <text>&lt;a href="http://revistas.unal.edu.co/index.php/acta_agronomica/article/view/16274" target="_blank" rel="noreferrer noopener"&gt;http://revistas.unal.edu.co/index.php/acta_agronomica/article/view/16274&lt;/a&gt;</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Adaptación del sector agrícola ante el cambio climático: propuesta de medidas a escala espacial fina en Guasave, Sinaloa, México</text>
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                <text>Ramiro Ahumada-Cervantes, Gilberto Velázquez-Angulo, Brenda Ahumada-Cervantes</text>
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                <text>El  cambio  climático  (CC)  que  actualmente  experimenta  el  planeta  es  una  realidad.  La  agricultura,  una  actividad importante para la generación de ingresos y para la producción de alimentos, podría ser una de las actividades primarias mayormente afectadas por este fenómeno. En este sentido, la adaptación de este sector se convierte en una herramienta clave para reducir su vulnerabilidad ante el CC. De esta manera, y a partir de conocer la vulnerabilidad agrícola del municipio de Guasave, Sinaloa, ante el CC, se proponen 11  medidas  de  adaptación  a  nivel  de  área  geoestadística  básica  rural  (AGEB  rural).  Dichas  medidas  po-drían ayudar a contrarrestar el efecto de 14 variables causales de vulnerabilidad del sector agrícola en siete AGEBs  consideradas  vulnerables.  Adicionalmente,  y  a  partir  del  análisis  de  ciertos  planes  y  programas  gubernamentales, que incluyen objetivos y líneas de acción encaminadas a mejorar la calidad de vida de la  población  mexicana,  se  identificaron  apoyos  gubernamentales  que  pudieran  ser  útiles  para  la  imple-mentación de las medidas de adaptación propuestas.</text>
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                <text>2018</text>
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                <text>10.15174/au.2018.1351</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Acta Universitaria</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="227249">
                <text>Universidad de Guanajuato</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Social Sciences, Science (General)</text>
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            <name>Relation</name>
            <description>A related resource</description>
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                <text>&lt;a href="https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1351/pdf" target="_blank" rel="noreferrer noopener"&gt;https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1351/pdf&lt;/a&gt;</text>
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