1646 10 20655 https://www.socictopen.socict.org/files/original/1c7797510e8794db236c28f908147f36.pdf 71da82d0de6b87535e4bfcd365ea94ef Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Relevant factors for the suspension of the payment of disputed tax - A comparative analysis Creator An entity primarily responsible for making the resource Linda van Zyl, Danielle van Wyk Description An account of the resource Section 164(3) of the Tax Administration Act No. 28 of 2011 gives a senior SARS official the discretion to suspend the payment of disputed tax or a portion thereof, having regard to relevant factors. Limited guidance is available in this regard. The objectives are to establish the concerns and uncertainties regarding the relevant factors and to determine whether a ‘suspension of the payment of disputed tax’ in terms of section 164(3) constitutes the granting of ‘credit’ in terms of a ‘credit agreement’ in terms of the National Credit Act, Act No. 34 of 2005. This is achieved by adopting an explanatory research approach and performing a literature review and comparative analysis respectively. The conclusion is reached that the current factors listed are not necessarily the most relevant ones. Recommendations are made to simplify the process and to revise and improve the wording regarding the relevant factors. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource Section 164(3) of the Tax Administration Act No. 28 of 2011, National Credit Act, Act No. 34 of 2005, Request, suspend, Relevant Factors, defer, payment, credit Identifier An unambiguous reference to the resource within a given context DOI: 10.4102/jef.v9i2.59 Source A related resource from which the described resource is derived Journal of Economic and Financial Sciences Publisher An entity responsible for making the resource available African Online Scientific Information Systems Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Economics as a science Language A language of the resource EN https://www.socictopen.socict.org/files/original/15294f67141276314b1c847612bc006e.pdf c884084a54145eb553fe642448ce72fe Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reliability Evaluation of the Factors That Influenced COVID-19 Patients’ Condition Creator An entity primarily responsible for making the resource Vitaly Levashenko, Jan Rabcan, Elena Zaitseva Description An account of the resource Health and safety is a problem that is intensively discussed nowadays. The failures in healthcare are called medical errors: if the patient’s condition worsens or he/she contracts an illness, then the actions that led to this are interpreted as medical errors. Medical errors can be the result of new procedures, extremes of age, complex or urgent care, improper documentation, illegible hand-writing, or patient actions. One of the ways to reduce medical error is an evaluation of its possibility, and then using the result of this evaluation to improve the medical organization units and processes in patient diagnosis, treatment, and care. This evaluation is possible based on methods of reliability engineering. The reliability engineering methods allow evaluating of different systems’ reliability and the influence of external and internal factors on system reliability. These methods’ application needs the system to be investigated or objective interpretation in terms of reliability engineering. Therefore, such a system in healthcare, for the diagnosis of disease, a patient’s treatment, the influence of different factors on a patient’s condition, and others, should be presented according to the rules and demands of reliability engineering. The first step is development of the mathematical representation of the investigated system or object according to the demands of the reliability analysis. One of the often-used mathematical representations in the reliability analysis of a system is the structure function. However, this mathematical representation needs completely specified initial data. The initial data from the healthcare domain for medical error analysis is uncertain and incompletely specified. Therefore, the development of this mathematical representation needs special methods. In this paper, a new method for the mathematical representation of system development based on uncertain and incompletely specified data is proposed. The system evaluation based on the structure function allows computing of many reliability indices and measures used in reliability engineering. The approbation of this method is considered based on an example of COVID-19 patients. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Classification, reliability analysis, Uncertain data, fuzzy classifier, system reliability Identifier An unambiguous reference to the resource within a given context 10.3390/app11062589 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Chemistry, Engineering (General). Civil engineering (General), Technology, Physics https://www.socictopen.socict.org/files/original/fbc4ecb3bedb4c02419f788bd16544e2.pdf 53bb9f931486ef9d0cdb03830cfbb26c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reliability of RT-PCR tests to detect SARS-CoV-2: risk analysis Creator An entity primarily responsible for making the resource Bezier Clément, Anthoine Géraldine, Charki Abdérafi Description An account of the resource The rapid escalation of the number of COVID-19 (Coronavirus Disease 2019) cases has forced countries around the world to implement systems for the widest possible testing of their populations. The World Health Organization (WHO) has in fact urged all countries to carry out as many tests as they can. Clinical laboratories have had to respond urgently to numerous and rising demands for diagnostic tests for SARS-CoV-2. The majority of laboratories have had to implement the RT-PCR (Reverse Transcriptase − Polymerase Chain Reaction) test method without the benefit of adequate experimental feedback. It is hoped that this article will make a useful contribution in the form of a methodology for the risk analysis of SARS-CoV-2 testing by RT-PCR and at the same time result reliability analysis of diagnostic tests, via an approach based on a combination of Fishbone Diagram and FMECA (Failure Mode, Effects, and Criticality Analysis) methods. The risk analysis is based on lessons learned from the actual experience of a real laboratory, which enabled the authors to pinpoint the principal risks that impact the reliability of RT-PCR test results. The probability of obtaining erroneous results (false positives or negatives) is implicit in the criticality assessment obtained via FMECA. In other words, the higher the criticality, the higher the risk of obtaining an erroneous result. These risks must therefore be controlled as a priority. The principal risks are studied for the following process stages: nucleic acid extraction, preparation of the mix and validation of results. For the extraction of nucleic acids, highly critical risks (exceeding the threshold set from experimentation) are the risk of error when depositing samples on the extraction plate and sample non-conformity. For the preparation of the mix the highest risks are a non-homogenous mix and, predominantly, errors when depositing samples on the amplification plate. For the validation of results, criticality can reach the maximum severity rating: here, the risks that require particular attention concern the interpretation of raw test data, poor IQC (Internal Quality Control) management and the manual entry of results and/or file numbers. Recommendations are therefore made with regard to human factor influences, internal contamination within the laboratory, management of reagents, other consumables and critical equipment, and the effect of sample quality. This article demonstrates the necessity to monitor, both internally and externally, the performance of the test process within a clinical laboratory in terms of quality and reliability. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, RT-PCR, SARS-CoV-2, reliability, Quality, test, risks, analysis, Fish Bone Diagram, FMECA Identifier An unambiguous reference to the resource within a given context 10.1051/ijmqe/2020009 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Technology https://www.socictopen.socict.org/files/original/00df7617dc676563670d035c563003ec.pdf ad2b2a03dfe0bd35a69df83941dee50c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reliable energy and responsive built environment: the missing links in COVID-19 response in resource-limited settings Creator An entity primarily responsible for making the resource Arvind Vashishta Rinkoo, Dinesh Songara, Arnika Sharma, Biswa Ranjan Patnaik, Rajesh Ranjan Singh, Rakesh Kumar Srivastava Description An account of the resource Abstract Irrespective of how the COVID-19 pandemic evolves over time across the globe, our past experiences with comparable zoonotic diseases demonstrate the significance of having resilient primary healthcare systems to successfully respond to public health emergencies. However, literature corroborates that in low- and middle-income countries, the primary healthcare systems are plagued with significant energy insecurity and inadequate built environment. These gaps in reliable energy and responsive built environment in primary healthcare systems are exacerbated during disruptive public health emergencies such as COVID-19. In this letter, we discuss the way forward to address these gaps and the policy and practical implications thereof. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Low- and middle-income countries, covid-19, PRIMARY HEALTH CARE, Built environment, energy insecurity Identifier An unambiguous reference to the resource within a given context 10.1186/s41182-020-00255-2 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Arctic medicine. Tropical medicine https://www.socictopen.socict.org/files/original/4ff29cef80c848a300087b9f721e3d68.pdf 415e72aefb07a614b4cf608019d1dc4b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Religiões da Terra e ética ecológica (Earth religions and ecological ethics) - DOI: 10.5752/P.2175-5841.2010v8n17p26 Creator An entity primarily responsible for making the resource Rosalira dos Santos Oliveira Description An account of the resource Na atual discussão sobre a importância de equilibrar a necessidade humana de intervir sobre a natureza com a nossa responsabilidade na preservação da vida no planeta, as chamadas religiões da terra ou religiões da natureza aportam uma contribuição fundamental.  Visando explorar essas relações, este artigo discute o impacto causado pelo processo de dessacralização do mundo na percepção do homem em relação ao mundo natural. Nesta linha, contrapõe a atitude teísta (característica das chamadas 'religiões do livro') à perspectiva cosmobiológica presente nas religiões da terra. Em seguida, o texto explora a concepção anímica de natureza e de mundo, compartilhada por essas últimas, destacando a sua concepção de uma natureza viva e a intuição de um parentesco entre o homem e os demais seres. Como exemplos desta postura, o texto apresenta algumas características presentes tanto nas religiões afro-brasileiras quanto nas tradições neo-pagãs.   A guisa de conclusão apresenta uma reflexão sobre as relações entre religião e ambientalismo e sobre a possível contribuição que a cosmovisão presente nas religiões da terra pode trazer para o movimento ecológico. Palavras-chave: Religião; Natureza; Ecologia; Animismo.    Abstract In the present discussion on the importance of balancing the human need for intervening in Nature with our responsibility to preserve life on the Planet, the so-called Earth Religions or Nature Religions play a fundamental role. With a view to exploring these relationships, this paper discusses the impact caused by the process of desacralising the human beings perception of the world in relation to Nature.   Along these lines, the theistic attitude (characteristic of the so-called Book Religions) is opposed to the cosmobiological perspective, present in the Earth Religions.  Following on this, the paper explores the animistic concept of Nature and the World shared by these religions. Furthermore, this work addresses to the animic conception of nature and world, shared by the cosmobiologic perspective, highlighting its conception of a live nature and the feeling of a bond between all live been as well as humans. With some example, the work shows some characteristics shared by the afrobrazilian religions and neopaganist traditions. To conclude, we present a reflection on the relationship between Religion and Environmentalism and on the possible contribution that the cosmovision present in the Earth Religions may bring to the Ecology Movement. Key words: Religion; Nature; Ecology; Animism.   Date A point or period of time associated with an event in the lifecycle of the resource 2010 Subject The topic of the resource Animism, Animismo, Religion, Religião, ecology, ecología, nature, natureza Source A related resource from which the described resource is derived Horizonte Publisher An entity responsible for making the resource available Pontifícia Universidade Católica de Minas Gerais Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Philosophy. Psychology. Religion, Religions. Mythology. Rationalism, Religion (General) Relation A related resource <a href="http://periodicos.pucminas.br/index.php/horizonte/article/view/1351" target="_blank" rel="noreferrer noopener">http://periodicos.pucminas.br/index.php/horizonte/article/view/1351</a> https://www.socictopen.socict.org/files/original/7c7e282b71850559fd68df7792d0bd34.pdf 295697d4482642da2ff2e682fe8923ea Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Religious live-streaming in response to coronavirus disease 2019 pandemic and the subsequent lockdown in South Africa Creator An entity primarily responsible for making the resource Mookgo Solomon Kgatle Description An account of the resource he novel coronavirus disease 2019 (COVID-19) is a virus that firstly struck in Wuhan, China, but its impact is felt by the whole world. The spread of the virus in South Africa caused President Cyril Ramaphosa to announce a national state of disaster in the country on 15 March 2020. Subsequently, on 23 March 2020, the President announced a total shutdown of the economy, which is also known as lockdown, effective from 26 March 2020. The restrictions of the lockdown affected different churches regardless of the denomination name. Churches were not allowed to congregate during this period for the safety of their followers and the citizens. This article reflects on the use of live-streaming via social media platforms such as zoom, Twitter, Facebook, YouTube and other apps by many churches in South Africa as a response or a way of coping with the lockdown. The argument is that although these various platforms proved to be effective on the one hand, they also raised other challenges on the other hand. The article will look at the ways of mediating the challenges of live-streaming and make recommendations. Intradisciplinary and/or interdisciplinary implications: The article is an interdisciplinary study between theology and media studies. The study seeks to demonstrate how churches used live-streaming via social media to cope with the restrictions of the lockdown in South Africa. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, World Health Organization;, Coronavirus disease 2019, social media, lockdown, Religion, churches, livestreaming Identifier An unambiguous reference to the resource within a given context 10.4102/ve.v41i1.2120 Source A related resource from which the described resource is derived Verbum et Ecclesia Publisher An entity responsible for making the resource available AOSIS Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Religion (General) https://www.socictopen.socict.org/files/original/1ea5807b63de689cfbbb80401646c334.pdf bf72b1bd975cdabf3dd543075a3dd2de Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Religious practices, COVID-19 and peasantry: a two-part analysis of the pandemic from an extension project Creator An entity primarily responsible for making the resource Álida Angélica Alves Leal, Luiz Paulo Ribeiro Description An account of the resource This paper analyzed the repercussions of the COVID-19 pandemic on religious practices of peasant subjects and rural communities in which students of the Degree in Rural Education of the Faculty of Education of the Universidade Federal de Minas Gerais (LECampo/FaE UFMG) work and residency. This is an extract from an investigation that is linked to the extension project “The people of the countryside and the COVID-19 pandemic”, created in April 2020. The methodological paths of the investigation consisted of the application of questionnaires with closed questions and open, answered by 36 students in the first stage (April/May 2020) and by 46 students in the second stage (July 2020). The data were analyzed by means of categorical content analysis. The results point to repercussions that relate to the following categories: a) socialization/sociability; b) interruption of activities in religious spaces; c) modes of remote participation in religious activities; d) hogar as a privileged place for remote religious practices; e) return from presential activities in collective religious spaces; f) relationship between pandemic, faith, punishment and divine protection. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Pandemic, religiosity, Peasantry, University extension Identifier An unambiguous reference to the resource within a given context 10.20873/uft.rbec.e10818 Source A related resource from which the described resource is derived Revista Brasileira de Educação do Campo Publisher An entity responsible for making the resource available Universidade Federal do Tocantins Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Education https://www.socictopen.socict.org/files/original/2fa072112094d6fc51c9fbff103c7b13.pdf 699a7c154b94e97d4358a50e27a258c1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Remarkable Cryptic Diversity of <i>Paratylenchus</i> spp. (Nematoda: Tylenchulidae) in Spain Creator An entity primarily responsible for making the resource Ilenia Clavero-Camacho, Carolina Cantalapiedra-Navarrete, Antonio Archidona-Yuste, Pablo Castillo, Juan Emilio Palomares-Rius Description An account of the resource In previous studies, fifteen species of Paratylenchus, commonly known as pin nematodes, have been reported in Spain. These plant-parasitic nematodes are ectoparasites with a wide host range and global distribution. In this research, 27 populations from twelve Paratylenchus species from 18 municipalities in Spain were studied using morphological, morphometrical and molecular data. This integrative taxonomic approach allowed the identification of twelve species, four of them were considered new undescribed species and eight were already known described. The new species described here are P. caravaquenus sp. nov., P. indalus sp. nov., P. pedrami sp. nov. and P. zurgenerus sp. nov. As for the already known described species, five were considered as first reports for the country, specifically P. enigmaticus, P. hamatus, P. holdemani, P. israelensis, and P. veruculatus, while P. baldaccii, P. goodeyi and P. tenuicaudatus had already been recorded in Spain. This study provides detail morphological and molecular data, including the D2-D3 expansion segments of 28S rRNA, ITS rRNA, and partial mitochondrial COI regions for the identification of different Paratylenchus species found in Spain. These results confirm the extraordinary cryptic diversity in Spain and with examples of morphostatic speciation within the genus Paratylenchus. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Cytochrome c oxidase subunit 1, D2-D3 of 28S rRNA, ITS rRNA, Phylogeny, molecular, morphology Identifier An unambiguous reference to the resource within a given context 10.3390/ani11041161 Source A related resource from which the described resource is derived Animals Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine, Zoology Relation A related resource <a href="https://www.mdpi.com/2076-2615/11/4/1161" target="_blank" rel="noreferrer noopener">https://www.mdpi.com/2076-2615/11/4/1161</a> https://www.socictopen.socict.org/files/original/7778785f5dce5f195ead2132fea5a8f4.pdf f977d2212da76844a1384987f580bbc8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Remdesivir Cuál es la evidencia para su utilización en el tratamiento de infección por COVID-19 Creator An entity primarily responsible for making the resource Cristian Dorati,, Perla Mordujovich-Buschiazzo,, Héctor Buschiazzo,, Gustavo H. Marin Description An account of the resource INTRODUCCIÓN: Si bien existe plausibilidad biológica para el uso de remdesivir en infecciones virales como las causadas por el nuevo coronavirus SARS-CoV-2, el verdadero lugar de este medicamento en el tratamiento de COVID-19 se conocerá cuando exista evidencia suficiente sobre su eficacia proveniente de ensayos clínicos de adecuada calidad. El objetivo de esta revisión es recabar y analizar la información científica disponible hasta la fecha sobre la eficacia y la seguridad de remdesivir para el tratamiento de los pacientes con COVID-19. MÉTODOS: Se realizó una búsqueda de información sobre eficacia y seguridad de remdesivir en bases de datos biomédicas, de informes de evaluación de tecnologías sanitarias, sitios web de ministerios de Salud, la Organización Panamericana de la Salud, la Organización Mundial de las Salud y agencias reguladoras de medicamentos. RESULTADOS: En la actualidad, la mayor parte de la evidencia proviene del ensayo clínico Adaptive COVID-19 Treatment Trial (ACTT-1). Resultados preliminares muestran que el tiempo promedio de recuperación fue de 11 días en el grupo de remdesivir, en comparación con 15 días en el grupo placebo. No se observaron diferencias estadísticamente significativas en la mortalidad. El perfil de seguridad de remdesivir muestra elevación de las enzimas hepáticas, insuficiencia renal y/o hipotensión al momento de la infusión. CONCLUSIONES: El análisis de la evidencia permite concluir que, hasta el momento, no existe información proveniente de estudios de calidad de evidencia alta, que permitan recomendar remdesivir para el tratamiento específico de pacientes con COVID-19, por fuera del contexto de un ensayo clínico Date A point or period of time associated with an event in the lifecycle of the resource 2020 Source A related resource from which the described resource is derived Revista Argentina de Salud Pública Publisher An entity responsible for making the resource available Ministerio de Salud Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine, Medicine (General) https://www.socictopen.socict.org/files/original/8dd36a940593fd88ff45a5915e23afd0.pdf 851fe7e4779462c41c102fb1bfb520bf Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Remdesivir (GS-5734) Impedes Enterovirus Replication Through Viral RNA Synthesis Inhibition Creator An entity primarily responsible for making the resource Hui Zhang, Min Yao, Dan Wang, Yuan Wang, Liang Zhang, Wei Ye, He Liu, Lin-Feng Cheng, Zhi-Kai Xu, Fang-Lin Zhang, XIN LV, Hong-wei MA, Yingfeng Lei, Chuantao Ye, Yue-Wu Yang, Yangchao Dong, Libin Qi Description An account of the resource Human enteroviruses are responsible for diverse diseases, from mild respiratory symptoms to fatal neurological complications. Currently, no registered antivirals have been approved for clinical therapy. Thus, a therapeutic agent for the enterovirus-related disease is urgently needed. Remdesivir (GS-5734) is a novel monophosphoramidate adenosine analog prodrug that exhibits potent antiviral activity against diverse RNA virus families, including positive-sense Coronaviridae and Flaviviridae and negative-sense Filoviridae, Paramyxoviridae, and Pneumoviridae. Currently, remdesivir is under phase 3 clinical development for disease COVID-19 treatment. Here, we found that remdesivir impeded both EV71 viral RNA (vRNA) and complementary (cRNA) synthesis, indicating that EV71 replication is inhibited by the triphosphate (TP) form of remdesivir. Moreover, remdesivir showed potent antiviral activity against diverse enteroviruses. These data extend the remdesivir antiviral activity to enteroviruses and indicate that remdesivir is a promising antiviral treatment for EV71 and other enterovirus infections. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource antivirals, Enterovirus, EV71, vRNA, crna, remdesivir (gs-5734) Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmicb.2020.01105 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology