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                <text>Ming Wang, Meiying Yan, Huifang Xu, Weili Liang, Biao Kan, Bo-Jian Zheng, Honglin Chen, Han Zheng, Yanmei Xu, Enmin Zhang, Hongxia Wang, Jingrong Ye, Gui-Chang Li, Machao Li, Zhigang Cui, Yufei Liu, Rong-Tong Guo, Xiao-ning Liu, Liu-Hua Zhan, Duan-Hua Zhou, Ailan Zhao, Rong Hai, Dongzhen Yu, Yi Guan, JianGuo Xu</text>
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                <text>Epidemiologic investigations showed that 2 of 4 patients with severe acute respiratory syndrome (SARS) identified in the winter of 2003–2004 were a waitress at a restaurant in Guangzhou, China, that served palm civets as food and a customer who ate in the restaurant a short distance from animal cages. All 6 palm civets at the restaurant were positive for SARS-associated coronavirus (SARS-CoV). Partial spike (S) gene sequences of SARS-CoV from the 2 patients were identical to 4 of 5 S gene viral sequences from palm civets. Phylogenetic analysis showed that SARS-CoV from palm civets in the restaurant was most closely related to animal isolates. SARS cases at the restaurant were the result of recent interspecies transfer from the putative palm civet reservoir, and not the result of continued circulation of SARS-CoV in the human population.</text>
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                <text>Matthew B. Frieman, Jun Chen, Thomas E. Morrison, Alan Whitmore, William Funkhouser, Jerrold M. Ward, Elaine W. Lamirande, Anjeanette Roberts, Mark Heise, Kanta Subbarao, Ralph S. Baric</text>
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                <text>Severe acute respiratory syndrome coronavirus (SARS-CoV) infection often caused severe end stage lung disease and organizing phase diffuse alveolar damage, especially in the elderly. The virus-host interactions that governed development of these acute end stage lung diseases and death are unknown. To address this question, we evaluated the role of innate immune signaling in protection from human (Urbani) and a recombinant mouse adapted SARS-CoV, designated rMA15. In contrast to most models of viral pathogenesis, infection of type I, type II or type III interferon knockout mice (129 background) with either Urbani or MA15 viruses resulted in clinical disease outcomes, including transient weight loss, denuding bronchiolitis and alveolar inflammation and recovery, identical to that seen in infection of wildtype mice. This suggests that type I, II and III interferon signaling play minor roles in regulating SARS pathogenesis in mouse models. In contrast, infection of STAT1-/- mice resulted in severe disease, high virus titer, extensive pulmonary lesions and 100% mortality by day 9 and 30 post-infection with rMA15 or Urbani viruses, respectively. Non-lethal in BALB/c mice, Urbani SARS-CoV infection in STAT1-/- mice caused disseminated infection involving the liver, spleen and other tissues after day 9. These findings demonstrated that SARS-CoV pathogenesis is regulated by a STAT1 dependent but type I, II and III interferon receptor independent, mechanism. In contrast to a well documented role in innate immunity, we propose that STAT1 also protects mice via its role as an antagonist of unrestrained cell proliferation.</text>
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                <text>Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Virus-2 (SARSCoV-2), pandemic has caused huge panic, havoc and global threats worldwide. The origin of this virushas been linked to animals, intermediate host is still to be identified, and studies are being carried outthat how it got transmitted to humans and acquired rapid human-to-human transmission. Within ashort time period of only 05 months, SARS-CoV-2 has spread to 213 countries, and till 28th May, 2020,nearly 5.8 million confirmed cases have been reported while taking lives of 0.36 million persons. Seeingthe current situation of rapid increase in COVID-19 cases daily in many countries, this seems to be thedeadliest pandemic after the 1918 Spanish Flu. There is currently no specific effective treatment forCOVID-19 and also in absence of vaccine the radical cure of the disease is far away. Researchers arepacing high to design and develop effective vaccines, drugs and therapeutics to counter COVID-19,however such efforts, clinical trials, necessary approvals and then to reach the level of bulk productionof many millions of doses may still take much time. Prevention and control of COVID-19 outbreaksrequires an evidence-based, multi-factorial and effective mitigation strategy to be adopted. The currentreview discusses on the research advancements, challenges and opportunities in COVID 19 managementwith a focus on its transmission, prevention, treatment and control.</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="38875">
                <text>pathogenesis, spike protein, SARS-CoV-2, Furin cleavage site, betacoronavirus proteins</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="38876">
                <text>10.21307/PM-2020.59.3.14</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="38877">
                <text>Postępy Mikrobiologii</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="38878">
                <text>Exeley Inc.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="38879">
                <text>Microbiology</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
