1714 10 20655 https://www.socictopen.socict.org/files/original/1445634ec8c1ad7a6a5e38e60c91176a.pdf 1461a25f78722f7de8ef315a9e17591d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Gestión de Políticas Públicas para el Desarrollo Local en Brasil Creator An entity primarily responsible for making the resource Rosinele da Silva de Oliveira, Mario Vasconcellos Sobrinho, PhD Description An account of the resource La Amazonía brasileña está en su tercera generación de políticas públicas enfocadas a la agricultura familiar. Esas generaciones coexisten actualmente y abarcan desde la estimulación del incremento de la producción hasta la innovación social que es la creación del mercado institucional vía el Programa de Adquisición de Alimentos (PAA) y el Programa Nacional de Alimentación Escolar (PNAE). El concepto adoptado como base de esta investigación es el de la Innovación Social y la teoría que sustenta los análisis es el del Capital Social. Como métodos se adoptaron el Estudio de Caso y el Análisis de Contenido. La cohorte es el conjunto de los 144 municípios del Estado de Pará. Los resultados señalan la necesidad de emerger un cambio hacia una cuarta generación de politicas públicas direccionadas a la agricultura familiar la cual, a su vez, tiene un carácter inmanentemente estratégico para el país y sirve de ejemplo para otros países conforme ha sido evidenciado por la Organización de las Naciones Unidas. Esta generación debe de ser capaz de crear una innovación social con una interfaz en las diversas áreas que afectan la vida en el campo para que así logre con efectividad el desarrollo local. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Análisis de políticas, Brasil, Pará, cambio de las políticas públicas, capital social, política agrícola Source A related resource from which the described resource is derived GIGAPP Estudios Working Papers Publisher An entity responsible for making the resource available Asociación GIGAPP Grupo de Investigación en Gobierno, Administración y Polí­ticas Públicas Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Political science Relation A related resource <a href="http://www.gigapp.org/ewp/index.php/GIGAPP-EWP/article/view/169" target="_blank" rel="noreferrer noopener">http://www.gigapp.org/ewp/index.php/GIGAPP-EWP/article/view/169</a> https://www.socictopen.socict.org/files/original/664c92f8b57f3986f8efb8626762b334.pdf ec0b2164d4cd75244421a00854042950 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A GASTRONOMIA E SEU USO TURÍSTICO: A CONTRIBUIÇÃO DO PROJETO DE EXTENSÃO “TURISMO E GASTRONOMIA: UNINDO SABORES E SABERES” PARA A VALORIZAÇÃO DO PATRIMÔNIO CULTURAL IMATERIAL Creator An entity primarily responsible for making the resource Roslaine Kovalczuk de Oliveira Garcia, Alexandra Marcella Zottis, Daniel Vicente Bonho Description An account of the resource O presente ensaio teórico trata do estudo sobre Turismo e Gastronomia na ótica da preservação e valorização do patrimônio cultural imaterial no âmbito do projeto de extensão Turismo e Gastronomia: unindo sabores e saberes para reflexões. No contexto institucional da Universidade Feevale/RS, as ações de extensão permitem aprofundar as relações de responsabilidade coletiva e de cooperação com a comunidade. O referido projeto tem como objetivo contribuir para a qualificação da gastronomia regional como atrativo turístico-cultural nos municípios de Campo Bom e de Novo Hamburgo, na região do Vale do Rio dos Sinos, identificar pratos regionais representativos das etnias formadoras dos referidos municípios e sensibilizar os empreendedores quanto à necessidade de maior valorização da gastronomia regional. O uso de elementos gastronômicos pelo turismo se faz mais presente em áreas rurais, características dessa região, o que pode proporcionar alternativas de geração de renda às comunidades e aos empreendimentos de agricultura familiar com o surgimento de negócios como a criação de serviços de alimentação, a formação de festas e de rotas gastronômicas. Quanto à metodologia, a pesquisa caracteriza-se pelo método exploratório, tendo como procedimentos técnicos a revisão bibliográfica e a pesquisa participante. Dessa forma, o artigo busca evidenciar a iniciativa do projeto e discutir a qualificação da gastronomia regional como patrimônio cultural imaterial. Palavras-chave: Turismo. Gastronomia regional. Patrimônio Cultural Imaterial. Projeto de Extensão. Vale do Rio dos Sinos/RS. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Identifier An unambiguous reference to the resource within a given context 10.25112/rgd.v12i2.327 Source A related resource from which the described resource is derived Revista Gestão e Desenvolvimento Publisher An entity responsible for making the resource available Universidade Feevale Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Social sciences (General), Economic growth, development, planning Relation A related resource <a href="http://periodicos.feevale.br/seer/index.php/revistagestaoedesenvolvimento/article/view/327" target="_blank" rel="noreferrer noopener">http://periodicos.feevale.br/seer/index.php/revistagestaoedesenvolvimento/article/view/327</a> https://www.socictopen.socict.org/files/original/1cf052c31e4c3434352ecd37b90d1830.pdf 195aeac4e7b133dbb32809b74f928031 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Implementación de estrategias en economía circular para la gestión adecuada de residuos domésticos en comunidades de zonas de baja mar (barrio Miramar) Buenaventura Creator An entity primarily responsible for making the resource Roslyn Obando Bravo, Rafael Oyaga Martínez Description An account of the resource Se presenta la investigación realizada en los años 2020-2021 sobre la implementación de un programa de Economía Circular en el barrio Miramar, Distrito de Buenaventura, como estrategia que permitiera a la comunidad realizar un programa de aprovechamiento de los residuos domésticos que son producidos y en su mayoría depositados en el mar. Se logró involucrar a la comunidad mediante procesos de capacitación y organización social, que permitieron que conocieran la importancia que tienen los residuos, su clasificación y separación en la fuente, para una adecuada disposición final, aprovechando e incluyéndolos en un nuevo ciclo de vida. Como resultado del proyecto la comunidad del Barrio Miramar entendió las bondades de la economía circular, cuál es la importancia que tiene clasificar los residuos en sus hogares, además de mejorar sus entornos y, por ende, generar ingresos económicos a través de la constitución de asociaciones que trabajen el tema. Finalmente se sugirió la actualización del PGIRS Distrital con la incorporación de una política de aprovechamiento de residuos, constituyendo centro de acopio, e instaurando política basada en la economía circular, eliminando la práctica “terreno ganados al mar” mediante uso de residuos. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Bajamar, Economia Circular, Estrategia, comunidad, resíduos Identifier An unambiguous reference to the resource within a given context 10.54606/Sextante2021.v25.04 Source A related resource from which the described resource is derived Revista Sextante Publisher An entity responsible for making the resource available Decanatura de Investigación - Escuela Naval de Suboficiales A.R.C. Barranquilla"" Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science Relation A related resource <a href="https://sextante-ensb.com/index.php/inicio/article/view/103" target="_blank" rel="noreferrer noopener">https://sextante-ensb.com/index.php/inicio/article/view/103</a> https://www.socictopen.socict.org/files/original/5ffc258971481e4cc64f9ece5c6ba13a.pdf 10cbf2efad1298bf7c814fe138685da8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource La gamificación como respuesta desafiante para motivar las clases en educación secundaria en el contexto de COVID-19 Creator An entity primarily responsible for making the resource Rosmery Villarroel, Héctor Santa María, Vladimir Quispe, Danny Ventosilla Description An account of the resource El objetivo fue determinar la correlación entre la gamificación y la motivación. Se desarrolló mediante la investigación cuantitativa, no experimental y correlacional. Se trabajó con una población censal de 253 estudiantes de educación básica regular. Para la obtención de datos se aplicó la Guía de observación de gamificación de García (2020) y el Cuestionario de motivación MSLQ de T. García et al. (1988). Los resultados indicaron que existe una relación muy baja, significativa de 0.025 (valor de p = 0.0694 > 0.05). Se concluye que la gamificación no se relaciona con la motivación de los estudiantes, la mayoría de los docentes, en el desarrollo de sus clases, no emplean herramientas digitales —elemento necesario en el dictado de clases a distancia y de forma virtual por la difícil situación ocasionada por el COVID-19—. Así mismo, los docentes adolecen de impericia en el manejo de las redes sociales, videoconferencias y formularios online. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, pandemia, educación, competencias digitales =, Motivación, Gamificación Identifier An unambiguous reference to the resource within a given context 10.35622/j.rie.2021.01.001 Source A related resource from which the described resource is derived Revista Innova Educación Publisher An entity responsible for making the resource available Instituto Universitario de Investigación Inudi Perú Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Education (General), Theory and practice of education https://www.socictopen.socict.org/files/original/559b22afb59c988dc238c866ced355e2.pdf cc8308266a6ee5a572168ac8173a8125 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Tracing SARS-Coronavirus Variant with Large Genomic Deletion Creator An entity primarily responsible for making the resource Rossa W.K. Chiu, Stephen S.C. Chim, Yu-kwan Tong, Kitty S. C. Fung, Paul K. S. Chan, Guo-Ping Zhao, Y.M. Dennis Lo Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource Letter, SARS, coronavirus, mutant, Epidemiology, Hong Kong Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1101.040544 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/61f0ba4c22db80b241c358291130699a.pdf a63b7b9074a8d9659ca04f53fd9b8924 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Income of cooperated farmers and agroindustries in Santa Catarina, Brazil Creator An entity primarily responsible for making the resource Rossana Pacheco da Costa Proença, Anete Araújo de Sousa, Rosaura Gazzola, Geraldo da Silva e Souza, Suellen Secchi Martinelli Description An account of the resource The study analyzed the impact of public programs: the National School Food Program (PNAE) and Food Acquisition Program (PAA) on the gross income of agribusinesses and family farmers marketing their products through cooperatives in Santa Catarina, southern Brazil. The data studied are 179 farmers and 74 agribusinesses. We model average sale returns per unit for farmers and agribusinesses as a function of the intensity of use of organic agriculture, type of sale: supermarkets or government programs, and type of food: fruits, vegetables, meat, eggs and dairy and bakery products. For both farmers and agribusinesses, we found to be more advantageous to sell processed foods to supermarkets. For farmers and agroindustries it is advantageous to sell processed foods for supermarkets. For individual farmers it is advantageous to sell fresh fruits and increase the proportion of sales of organic products. For agribusinesses, selling vegetables resulted in lower income and the sale of organic products does not significantly affect the income of the agroindustries. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Agricultura orgânica, Alimentación Escolar, PAA/PNAE, Políticas Públicas, Supermercados Identifier An unambiguous reference to the resource within a given context 10.18378/rvads.v14i1.5977 Source A related resource from which the described resource is derived Revista Verde de Agroecologia e Desenvolvimento Sustentável Publisher An entity responsible for making the resource available Grupo Verde de Agroecologia e Abelhas (GVAA) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Geography. Anthropology. Recreation, Environmental sciences Relation A related resource <a href="https://www.gvaa.com.br/revista/index.php/RVADS/article/view/5977" target="_blank" rel="noreferrer noopener">https://www.gvaa.com.br/revista/index.php/RVADS/article/view/5977</a> https://www.socictopen.socict.org/files/original/da6562258cac014d94fe5c7fbaf298f2.pdf 0c29bac5c12a183c5af4adf6534f43f5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Computer generated holography with intensity-graded patterns Creator An entity primarily responsible for making the resource Rossella Conti, Osnath Assayag, Vincent de Sars, Marc Guillon, Valentina Emiliani Description An account of the resource Computer Generated Holography achieves patterned illumination at the sample plane through phase modulation of the laser beam at the objective back aperture. This is obtained by using liquid crystal-based spatial light modulators (LC-SLMs), which modulate the spatial phase of the incident laser beam. A variety of algorithms are employed to calculate the phase modulation masks addressed to the LC-SLM. These algorithms range from simple gratings-and-lenses to generate multiple diffraction-limited spots, to iterative Fourier-transform algorithms capable of generating arbitrary illumination shapes perfectly tailored on the base of the target contour. Applications for holographic light patterning include multi-trap optical tweezers, patterned voltage imaging and optical control of neuronal excitation using uncaging or optogenetics. These past implementations of computer generated holography used binary input profile to generate binary light distribution at the sample plane. Here we demonstrate that using graded input sources, enables generating intensity graded light patterns and extend the range of application of holographic light illumination. At first, we use intensity-graded holograms to compensate for LC-SLM position dependent diffraction efficiency or sample fluorescence inhomogeneity. Finally we show that intensity-graded holography can be used to equalize photo evoked currents from cells expressing different level of chanelrhodopsin2 (ChR2), one of the most commonly used optogenetics light gated channels, taking into account the non-linear dependence of channel opening on incident light. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource microscopy, optogenetics, Computer generated holography, graded intensity holograms, ChR2 photostimulation Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fncel.2016.00236 Source A related resource from which the described resource is derived Frontiers in Cellular Neuroscience Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neurosciences. Biological psychiatry. Neuropsychiatry Language A language of the resource EN https://www.socictopen.socict.org/files/original/db526c38495d80a7e3dad78339926029.pdf 0721d970e2d4a8e0f57325d7913c4d41 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SEASONAL WORKERS BEFORE THE COVID-19 ERA: ANALYSIS OF THE LEGISLATION WITHIN THE CONTEXT OF EASTERN EUROPE Creator An entity primarily responsible for making the resource Rossen Kostadinov Koroutchev* Description An account of the resource This paper analyzes the phenomenon of seasonal workers in Europe before the Covid-19 pandemic and discusses the legislation for intermediation job intermediation agencies in several East European countries such as Bulgaria, Romania and Poland. Additionally we discuss the typical patterns for seasonal migration in European context. We also analyze the situation of seasonal workers in Scandinavia (the berry picking activity in Sweden), in Spain (the orange picking in the Mediterranean regions) as well as the Ukrainian seasonal workers in some of the Visegrad-4 countries (Poland, Czech Republic and Slovakia). Finally, we briefly discuss some novel approaches which might be used as regulation mechanisms. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Eastern Europe, seasonal workers, V4 countries, intermediation job agencies, visa formalities Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Journal of Liberty and International Affairs Publisher An entity responsible for making the resource available Institute for Research and European Studies Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Political theory https://www.socictopen.socict.org/files/original/cb4d2c67cfc0a77ac5e06973985619b6.pdf a1749bfca00ec86df97f96b11f3f49a8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Improved microarray gene expression profiling of virus-infected cells after removal of viral RNA Creator An entity primarily responsible for making the resource Rottier Peter JM, Bouwmeester Diane, Setterquist Robert A, Whitley Penn, Raaben Matthijs, de Haan Cornelis AM Description An account of the resource Abstract Background Sensitivity and accuracy are key points when using microarrays to detect alterations in gene expression under different conditions. Critical to the acquisition of reliable results is the preparation of the RNA. In the field of virology, when analyzing the host cell's reaction to infection, the often high representation of viral RNA (vRNA) within total RNA preparations from infected cells is likely to interfere with microarray analysis. Yet, this effect has not been investigated despite the many reports that describe gene expression profiling of virus-infected cells using microarrays. Results In this study we used coronaviruses as a model to show that vRNA indeed interferes with microarray analysis, decreasing both sensitivity and accuracy. We also demonstrate that the removal of vRNA from total RNA samples, by means of virus-specific oligonucleotide capturing, significantly reduced the number of false-positive hits and increased the sensitivity of the method as tested on different array platforms. Conclusion We therefore recommend the specific removal of vRNA, or of any other abundant 'contaminating' RNAs, from total RNA samples to improve the quality and reliability of microarray analyses. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2164-9-221 Source A related resource from which the described resource is derived BMC Genomics Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics, Biotechnology Language A language of the resource EN https://www.socictopen.socict.org/files/original/d0699a3979939e3da865b15f0a893704.pdf cf7a7c26cb057441a0911bb1a5a4c867 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection <it>in vivo</it> Creator An entity primarily responsible for making the resource Rottier Peter JM, Raaben Matthijs, de Haan Cornelis AM, Groot Koerkamp Marian JA Description An account of the resource Abstract Background The role of type I IFNs in protecting against coronavirus (CoV) infections is not fully understood. While CoVs are poor inducers of type I IFNs in tissue culture, several studies have demonstrated the importance of the type I IFN response in controlling MHV infection in animals. The protective effectors against MHV infection are, however, still unknown. Results In order to get more insight into the antiviral gene expression induced in the brains of MHV-infected mice, we performed whole-genome expression profiling. Three different mouse strains, differing in their susceptibility to infection with MHV, were used. In BALB/c mice, which display high viral loads but are able to control the infection, 57 and 121 genes were significantly differentially expressed (≥ 1.5 fold change) upon infection at 2 and 5 days post infection, respectively. Functional association network analyses demonstrated a strong type I IFN response, with Irf1 and Irf7 as the central players. At 5 days post infection, a type II IFN response also becomes apparent. Both the type I and II IFN response, which were more pronounced in mice with a higher viral load, were not observed in 129SvEv mice, which are much less susceptible to infection with MHV. 129SvEv mice lacking the type I interferon receptor (IFNAR-/-), however, were not able to control the infection. Gene expression profiling of these mice identified type I IFN-independent responses to infection, with IFN-γ as the central player. As the BALB/c and the IFNAR-/- 129SvEv mice demonstrated very similar viral loads in their brains, we also compared their gene expression profiles upon infection with MHV in order to identify type I IFN-dependent transcriptional responses. Many known IFN-inducible genes were detected, several of which have previously been shown to play an important protective role against virus infections. We speculate that the additional type I IFN-dependent genes that we discovered may also be important for protection against MHV infection. Conclusion Transcriptional profiling of mice infected with MHV demonstrated the induction of a robust IFN response, which correlated with the viral load. Profiling of IFNAR-/- mice allowed us to identify type I IFN-independent and -dependent responses. Overall, this study broadens our present knowledge of the type I and II IFN-mediated effector responses during CoV infection in vivo. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2164-10-350 Source A related resource from which the described resource is derived BMC Genomics Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics, Biotechnology