1735 10 20655 https://www.socictopen.socict.org/files/original/70150da71aa4a0a6b53e6c8d1ebae01d.pdf e16ed4e3303422f311a0f741d82f64c2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Characteristics and Outcomes of the Patients Infected with SARS-CoV-2 Admitted to Intensive Care Units: Erciyes University COVID-19 Center Experience Creator An entity primarily responsible for making the resource Şahin Temel, Kürşat Gündoğan, Birkan Ülger, Hüseyin Arican, Kadir Bulut, Ali Sari, Hilal Sipahioğlu, Ali Yeşiltepe, Ayşim Ertürk, Özgür Karabıyık, Murat Sungur Description An account of the resource Objective: This study aims to investigate the characteristics and outcomes of patients infected with SARS-CoV-2 admitted to the intensive care unit (ICU). Materials and Methods: This study was performed retrospectively in a medical ICU. All patients admitted to were either laboratory-confirmed or clinically probable COVID-19 patients, and all patients admitted to our ICU during this period were enrolled in the study. Results: We enrolled 47 patients. The mean age was 68.4+-13.4 years and 66% of patients were male. The most common co-morbidities were hypertension (66%) and cardiovascular diseases (40%). The mean APACHE II score was 22.4+-8.5, and the first-day median SOFA score was 5 (range: 1–12). Hydroxychloroquine was the most common drug prescribed (78.7%). All patients received at least one antibiotic other than Azithromycin as the most common drug was Piperacillin-Tazobactam (63.8%). Among 47 patients, 55.3% (28 patients) who were admitted to the ICU needed invasive mechanical ventilation. Prone positioning was used in 23% (6 patients) of mechanically ventilated patients. The mean positive end-expiratory pressure (PEEP) was 10+-3 cm H2O. The median PaO2/FiO2 ratio was 200 (range, 91–458). The most common ventilator mode was SIMV-PSV volume-controlled mode. ICU mortality rate was 34% (16 patients). Conclusion: The most common reason to admit SARS-CoV-2 infected patients to our ICU was acute respiratory failure and hypoxemia during the first month of pandemics. COVID-19 patients have a high mortality rate when they develop severe disease. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, Intensive care unit, erciyes university Identifier An unambiguous reference to the resource within a given context 10.14744/etd.2020.00907 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) https://www.socictopen.socict.org/files/original/105b26af72b933f11b1e276fb44c9bc7.pdf 803dfbcab682855d8f7bb81f1d8c0c92 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Arapan-S: a fast and highly accurate whole-genome assembly software for viruses and small genomes Creator An entity primarily responsible for making the resource Sahli Mohammed, Shibuya Tetsuo Description An account of the resource Abstract Background Genome assembly is considered to be a challenging problem in computational biology, and has been studied extensively by many researchers. It is extremely difficult to build a general assembler that is able to reconstruct the original sequence instead of many contigs. However, we believe that creating specific assemblers, for solving specific cases, will be much more fruitful than creating general assemblers. Findings In this paper, we present Arapan-S, a whole-genome assembly program dedicated to handling small genomes. It provides only one contig (along with the reverse complement of this contig) in many cases. Although genomes consist of a number of segments, the implemented algorithm can detect all the segments, as we demonstrate for Influenza Virus A. The Arapan-S program is based on the de Bruijn graph. We have implemented a very sophisticated and fast method to reconstruct the original sequence and neglect erroneous k-mers. The method explores the graph by using neither the shortest nor the longest path, but rather a specific and reliable path based on the coverage level or k-mers’ lengths. Arapan-S uses short reads, and it was tested on raw data downloaded from the NCBI Trace Archive. Conclusions Our findings show that the accuracy of the assembly was very high; the result was checked against the European Bioinformatics Institute (EBI) database using the NCBI BLAST Sequence Similarity Search. The identity and the genome coverage was more than 99%. We also compared the efficiency of Arapan-S with other well-known assemblers. In dealing with small genomes, the accuracy of Arapan-S is significantly higher than the accuracy of other assemblers. The assembly process is very fast and requires only a few seconds. Arapan-S is available for free to the public. The binary files for Arapan-S are available through http://sourceforge.net/projects/dnascissor/files/. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1756-0500-5-243 Source A related resource from which the described resource is derived BMC Research Notes Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Science (General), Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/3b78d227d6695a83cc7e416e37069b44.pdf f3fb13d43e533712033ff69b8fdc1ea9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correlation analysis of coagulation dysfunction and liver damage in patients with novel coronavirus pneumonia: a single-center, retrospective, observational study Creator An entity primarily responsible for making the resource Sai Chen, Hanting Liu, Tie Li, Rong Huang, Rong Gui, Junhua Zhang Description An account of the resource Background The novel coronavirus disease 2019 (COVID-19) is currently breaking out worldwide. COVID-19 patients may have different degrees of coagulopathy, but the mechanism is not yet clear. We aimed to analyse the relationship between coagulation dysfunction and liver damage in patients with COVID-19. Methods A retrospective analysis of 74 patients with COVID-19 admitted to the First People’s Hospital of Yueyang from 1 January to 30 March 2020 was carried out. According to the coagulation function, 27 cases entered the coagulopathy group and 47 cases entered the control group. A case control study was conducted to analyse the correlation between the occurrence of coagulation dysfunction and liver damage in COVID-19 patients. Results Alanine aminotransferase (ALT) and aspartate aminotransferase (AST), markers of liver damage, were positively correlated with coagulopathy (p = 0.039, OR 2.960, 95% CI 1.055–8.304; and p = 0.028, OR 3.352, 95% CI 1.137–9.187). Alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GT), and total bilirubin (TBIL) were not statistically correlated with coagulopathy. According to the diagnosis and treatment plan, the included cases were classified into mild, moderate, severe, and critical. The results showed that the occurrence of coagulation dysfunction had no statistical correlation with the severity of COVID-19. Conclusion Coagulation dysfunction in patients with COVID-19 is closely related to liver damage. A longer course of the disease may cause a vicious circle of coagulopathy and liver damage. Clinicians need to closely monitor coagulation and liver function tests and to give prophylactic or supportive therapy when needed. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, pneumonia, SARS-CoV-2, liver damage, blood coagulation dysfunction Identifier An unambiguous reference to the resource within a given context 10.1080/03009734.2020.1822960 Source A related resource from which the described resource is derived Upsala Journal of Medical Sciences Publisher An entity responsible for making the resource available Upsala Medical Society Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/1ebde3b944ea7d787df09f2010810c00.pdf 219b8a707539d4173a6ec4c4c5680255 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Effect of Climate and the Equator on the Total Coronavirus Cases of the Nine Countries from Africa Creator An entity primarily responsible for making the resource Said Benramache, Hanane Bougherara Description An account of the resource On the 01 March, 2020, an outbreak of coronavirus disease 2019 (COVID-19) has resulted in 88 585 confirmed cases. African countries move from COVID-19 readiness to respond as many confirmed cases. The equator differs from the rest of the world in its climate and environment. In this work we conducted a comparative study of cases of coronavirus infection and the number of deaths, this study was investigated in nine countries from Africa with the same climate and which belong to the equator, where the results were compared with the relation to the general population and total area. From the studied results, we found a zero % of the Deaths for Rwanda, Equatorial Guinea and Uganda. The equator countries of Africa have not been affected much by this virus, Climate found in the equator countries helped these countries to obtain a small number of injuries, Air and temperature affected the number of deaths, and the equator countries authorize its climate to help them acquire special immunity. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource climate, Africa, equator, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.5799/jcei/8263 Source A related resource from which the described resource is derived Journal of Clinical and Experimental Investigations Publisher An entity responsible for making the resource available Association of Health Investigations Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/601d00ecd23f6ca472ca4d39bfdb64e8.pdf 9e11f7ff04fdaa1e21eedc024ec45c4a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2 Creator An entity primarily responsible for making the resource Saif Ur Rehman, Laiba Shafique, Awais Ihsan, Qingyou Liu Description An account of the resource Over the last two decades, the world experienced three outbreaks of coronaviruses with elevated morbidity rates. Currently, the global community is facing emerging virus SARS-CoV-2 belonging to Betacoronavirus, which appears to be more transmissible but less deadly than SARS-CoV. The current study aimed to track the evolutionary ancestors and different evolutionary strategies that were genetically adapted by SARS-CoV-2. Our whole-genome analysis revealed that SARS-CoV-2 was the descendant of Bat SARS/SARS-like CoVs and bats served as a natural reservoir. SARS-CoV-2 used mutations and recombination as crucial strategies in different genomic regions including the envelop, membrane, nucleocapsid, and spike glycoproteins to become a novel infectious agent. We confirmed that mutations in different genomic regions of SARS-CoV-2 have specific influence on virus reproductive adaptability, allowing for genotype adjustment and adaptations in rapidly changing environments. Moreover, for the first time we identified nine putative recombination patterns in SARS-CoV-2, which encompass spike glycoprotein, RdRp, helicase and ORF3a. Six recombination regions were spotted in the S gene and are undoubtedly important for evolutionary survival, meanwhile this permitted the virus to modify superficial antigenicity to find a way from immune reconnaissance in animals and adapt to a human host. With these combined natural selected strategies, SARS-CoV-2 emerged as a novel virus in human society. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource SARS-CoV-2, SARS-CoV, phylogeny, genomic structure, evolutionary strategies, mutations, recombination or reassortment Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/pathogens9030240 Source A related resource from which the described resource is derived Pathogens Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/bb741e016eae9a0f5f07ef08e7fcbfeb.pdf 4295c34e7565fa183de417fc815e7ae8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Tacrolimus use and COVID-19 infection in patients after solid organ transplantation. Creator An entity primarily responsible for making the resource Saifu Yin, Xianding Wang, Turun Song Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1053/j.gastro.2021.01.223 Source A related resource from which the described resource is derived Gastroenterology https://www.socictopen.socict.org/files/original/b3a0ae3dedd043115edcc44a35cf5e22.pdf 943ac6fa95d3e6aea18a016f9f86edae Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Economic analysis of organic greenhouse lettuce production in Turkey Análise econômica da produção orgânica de alface em estufas na Turquia Creator An entity primarily responsible for making the resource Sait Engindeniz, Yuksel Tuzel Description An account of the resource Health issues and environmental concerns have drawn the attention to organic agriculture aiming to protect the natural balance and to produce without damaging the environment. This study aims determining economic feasibility of organic greenhouse lettuce (Lactuca sativa L.) in an on farm trial, to foster organic greenhouse vegetable production in the preservation area of Tahtali Dam, projected as the sole water resource of Izmir, Turkey's third largest. A 384 m² greenhouse, constructed of galvanized metal tubing anchored and covered with a polyethylene was analyzed to identify typical operation procedures, and to determine unitary construction and operation cost. Organic lettuces were produced during autumn season of 2001-2002, testing different organic fertilizer applications, including two rates of farmyard and poultry manure (30 and 50 t ha-1) with and without two organic fertilizers based on either bacteria or algae. Economical analysis was performed according to different organic fertilizer applications. Cost, yield, and price data were analyzed to determine the profitability of a typical operation. Net return obtained from organic lettuce growing ranged between us $ 0.376 and us $ 0.901 m-2, as a result of different fertilizer applications.Preocupações sanitárias e ambientais têm atraído a atenção para a prática da agricultura orgânica como meio de proteger o balanço ambiental e produzir sem danificar o ambiente. Este estudo objetiva determinar a viabilidade econômica da produção em estufa da alface (Latuca sativa L.) em um ensaio de campo, a fim de incentivar a produção orgânica de vegetais na área de preservação do Reservatório Tahtali, projetado como o único recurso hídrico de Izmir, a terceira maior cidade da Turquia. Uma estufa de tubos galvanizados (384 m²), ancorados e cobertos com polietileno, foi analisada para identificar procedimentos operacionais padronizados e determinar custos unitários de construção e operação. Alfaces orgânicas foram produzidas no outono de 2001-2002, testando diferentes aplicações de sobras compostadas e esterco de granja avícola como fertilizantes orgânicos (30 e 50 t ha-1), com ou sem a adição de fertilizantes comerciais bacterianos ou algais. A análise econômica foi feita de acordo com as quantidades de fertilizantes utilizadas. A determinação da lucratividade foi feita com base na análise de dados de custos, produtividade e preço. O lucro líquido obtido da produção orgânica de alface em estufa variou entre US$ 0.376 e US$ 0.901 m-2. Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Agricultura orgânica, Análise de custo, cost analysis, fertilizante orgânico, organic farming, organic fertilizer, vegetable, vegetais Identifier An unambiguous reference to the resource within a given context 10.1590/S0103-90162006000300012 Source A related resource from which the described resource is derived Scientia Agricola Publisher An entity responsible for making the resource available Universidade de São Paulo Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General) Relation A related resource <a href="http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0103-90162006000300012" target="_blank" rel="noreferrer noopener">http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0103-90162006000300012</a> https://www.socictopen.socict.org/files/original/621540aa3bc5c45bfa7c2957900b430f.pdf e75ff4d196a64ac34bc193ce68ec870d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Economic consequences of resource trade-offs for special disaster-blessed industries: the case of COVID-19 pandemic Economic consequences of COVID-19 pandemic Creator An entity primarily responsible for making the resource Sajid Muhammad Jawad Description An account of the resource The new COVID-19 pandemic has spread to almost every nation in the world. Most of the available literature on the economic effects of COVID-19 focuses mainly on the recessionary effects of COVID-19 on different industries and aggregate economies. However, some industries, such as masks (surgical and N95, etc.), ventilators and miscellaneous medical services, benefit economically from the current COVID-19 disaster. More and more resources have been diverted to these industries due to the increased demand of these special industries. Excessive demand from these special industries will eventually return to normal or, under special conditions, fall below their normal (usual) demand once the pandemic has ended. Which, in turn, will not only affect these special industries, but can also have an impact on the recovery of aggregate economies around the globe. The study presents a comprehensive model for the different phases of the short-term lifecycle of these special industries. Presentation of the working and economic backlash resulting from the eventual decline in demand of these industries may encourage world economic policymakers to look beyond the current disastrous situation and to devise the necessary monetary and fiscal policies for the future COVID-19 free era. Otherwise, it will be difficult for the economies recovering from COVID-19 pandemic to move back to normal functioning, because the additional resources (such as labor and capital) allocated to these special industries may be idle for some time, which may increase the burden and drag the recovering economies of the COVID-19 pandemic into a deeper recession even when the pandemic is over. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1051/e3sconf/202123502007 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences https://www.socictopen.socict.org/files/original/4583bc0eb3ef2b0017f802caf8d8402e.pdf bc44931acefb67ba7d78cd3affce02b5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Comparison of PRE and POST COVID-19 Pandemic burn statistics: Initial experience from Rawalian Burn Center, Holy Family Hospital, RMU, Rawalpindi, Pakistan Creator An entity primarily responsible for making the resource Sajid Rashid Description An account of the resource Objectives: To determine the change in the trend of burn patient epidemiology after the COVID-19 pandemic in terms of frequency of burn injury and mortality rate. Material and Methods: This cross-sectional descriptive study was carried out at Rawalian burn center, Plastic Surgery Department, Holy Family Hospital RMU Rawalpindi from 1st March to 31st July over a period of 05 months. All burn patients reporting to the Rawalian burn center during the specified period were included in this study by consecutive sampling. Patients were mainly admitted from emergency and some from OPD following the standard admission, inclusion, and exclusion criteria Results: Mean age of patients in the pre-COVID (Control) period March to July 2019 was 28.84 years with an SD of ±3.73. There were 63% females and 37% males. The total burn surface area range was 8-65% during this period. Whereas in the post-COVID period, March to July 2020 mean age of patients was 29.13 years with an SD of ±4.06. There were 60% females and 40% males. Whereas the total burn surface area range was 10-61% during this period. Frequency per month of burn injury progressively reduced to 58 patients and mortality rate to 1 in July 2020 (post-COVID period). The overall frequency of burn injury (n) during the control period was 367 patients whereas in the post-COVID period is reduced to 326 patients. So there was an 11.17% reduction as compared to the control period. A Chi-square test was applied and was found significant. Conclusion: Based on the current study it can be concluded that there is a progressive fall in frequency of burn injury and mortality rate during the ongoing COVID-19 pandemic as compared to the PRE-COVID period however further studies are needed to explore the cause of this falling trend.   Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, mortality rate, burn frequency, Burn Statistics, Rawalian Burn Center Identifier An unambiguous reference to the resource within a given context 10.37939/jrmc.v25i1.1461 Source A related resource from which the described resource is derived Journal of Rawalpindi Medical College Publisher An entity responsible for making the resource available Rawalpindi Medical University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/cf9a514efdf92ec916d68c914cc2ec2e.pdf bd1f86f84187e8a30dcfdc4cfcbf163f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Structure-Based Virtual Screening Identifies Multiple Stable Binding Sites at the RecA Domains of SARS-CoV-2 Helicase Enzyme Creator An entity primarily responsible for making the resource Sajjad Ahmad, Yasir Waheed, Saba Ismail, Saadia Bhatti, Sumra Wajid Abbasi, Khalid Muhammad Description An account of the resource With the emergence and global spread of the COVID-19 pandemic, the scientific community worldwide has focused on search for new therapeutic strategies against this disease. One such critical approach is targeting proteins such as helicases that regulate most of the SARS-CoV-2 RNA metabolism. The purpose of the current study was to predict a library of phytochemicals derived from diverse plant families with high binding affinity to SARS-CoV-2 helicase (Nsp13) enzyme. High throughput virtual screening of the Medicinal Plant Database for Drug Design (MPD3) database was performed on SARS-CoV-2 helicase using AutoDock Vina. Nilotinib, with a docking value of −9.6 kcal/mol, was chosen as a reference molecule. A compound (PubChem CID: 110143421, ZINC database ID: ZINC257223845, eMolecules: 43290531) was screened as the best binder (binding energy of −10.2 kcal/mol on average) to the enzyme by using repeated docking runs in the screening process. On inspection, the compound was disclosed to show different binding sites of the triangular pockets collectively formed by Rec1A, Rec2A, and 1B domains and a stalk domain at the base. The molecule is often bound to the ATP binding site (referred to as binding site 2) of the helicase enzyme. The compound was further discovered to fulfill drug-likeness and lead-likeness criteria, have good physicochemical and pharmacokinetics properties, and to be non-toxic. Molecular dynamic simulation analysis of the control/lead compound complexes demonstrated the formation of stable complexes with good intermolecular binding affinity. Lastly, affirmation of the docking simulation studies was accomplished by estimating the binding free energy by MMPB/GBSA technique. Taken together, these findings present further in silco investigation of plant-derived lead compounds to effectively address COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Molecular Dynamic Simulation, phytochemicals, SARS-CoV-2 helicase Identifier An unambiguous reference to the resource within a given context 10.3390/molecules26051446 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry