1737 10 20655 https://www.socictopen.socict.org/files/original/2fb5f4f83ea9313289f8afe20694e22f.pdf 7c7e9e6688f357d8d5af802de26c403e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Los retos de la produccion de anonaceas en Mexico: produccion y mercadeo Creator An entity primarily responsible for making the resource Salas Praiz Joel Salomón Description An account of the resource Analizando los retos actuales del Mundo de las Anonáceas en México, debemos tomar en cuenta todos los participantes, desde el productor, pasando por los mercados de destino y hasta el consumidor final. En un ambiente agroalimentario globalizado y cada vez más competitivo, los negocios que se adaptan para satisfacer las necesidades de los consumidores son los únicos que sobrevivirán y crecerán. La Cooperación Inter-Empresarial, denominada por algunos 'Empresa-Red'; para explotar conjuntamente las ventajas de la gran empresa (consorcio) y de la pequeña empresa (rapidez), es el primer gran reto. Un segundo reto lo integran los factores que impulsan el mercado: La Seguridad Alimentaria, La calidad del producto, La Innovación, La disminución de Costos, y El Desarrollo de Nuevos Mercados. Un tercer reto es La adaptación competitiva de las anonáceas al cambio climático. Encontrar microorganismos eficientes de control biológico para proteger alimentos, resulta un cuarto reto y una alternativa prometedora para el control de organismos indeseables. Posicionar a las Anonáceas como la Fruta Emblemática de América Latina en los Mercados Internacionales operando una Cadena de Valor Continental, y Converger con todos los actores continentales en este gran esfuerzo que impone la dinámica mundial; es sin duda, el Gran Reto y nuestra invitación, para asumirlo, en este memorable Congreso Internacional. Así como, la Integración del Ecosistema Continental de Innovación para el Desarrollo Sustentable de las Anonáceas. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource Annona muricata, Cambio climático, Factores Impulsores del Mercado, Huella de Carbono, cadena de valor, empresa-red Identifier An unambiguous reference to the resource within a given context 10.1590/S0100-29452014000500008 Source A related resource from which the described resource is derived Revista Brasileira de Fruticultura Publisher An entity responsible for making the resource available Sociedade Brasileira de Fruticultura Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Plant culture Relation A related resource <a href="http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0100-29452014000500008&amp;lng=en&amp;tlng=en" target="_blank" rel="noreferrer noopener">http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0100-29452014000500008&amp;lng=en&amp;tlng=en</a> https://www.socictopen.socict.org/files/original/d59f10d80cf4ee84b78cf631b1c068a8.pdf f4787f7dd5183112bb7b2f1e00c2565a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource CONSEQUENCES OF COVID-19 ON DIGITAL ECONOMY IN THE HORN OF AFRICA Creator An entity primarily responsible for making the resource Saleamlak Fentaw GETAHUN, Sintayehu DEJENE Description An account of the resource Research background: The Horn of Africa is arguably the most vulnerable region for many shocks. Currently, the coronavirus disease-2019 (COVID-19) is spreading fast in the region. The number of new cases and the mortality of this pandemic have increased dramatically. As lockdown and movement restrictions are the major strategies suggested to minimize the spread of the virus, the impacts of the COVID-19 pandemic are not only limited to public health but also have a major impact on the economic aspects. Purpose of the article: This review paper aims to synthesize the consequences of COVID-19 on the digital economy in the Horn of Africa. We review and recommend adopting the digital economy could be the remedy to go through COVID-19 safely as the world sees digital companies boom during the pandemic. Methods: To achieve our purpose, we applied qualitative analysis and synthesis as a method, and recently published papers in the area (most suitable to our aim) are included as data sources. Findings & Value added: The Horn region is already feeling the economic impact of the virus and we discussed it in terms of monetary, fiscal, current account balance, and unemployment expected impacts. However, this pandemic is not just about adverse impacts; it is also about unanticipated business opportunities. In this perspective, the decline of the international oil price during this pandemic can be seen as a blessing in disguise since countries in the region are net importers of crude oil. Moreover, Ethiopia’s coffee export has increased rapidly at a level of record sales of about 665 million dollars from July 2019 to April 2020 (10 months’ export). The lion’s share of this upsurge has been achieved because of the rise in the coffee consumption from homes of the country’s Arabic coffee importers, such as Germany, the U.S, and Saudi Arabia due to the lockdown measures. The paper also covers the prospects of the virus by pinpointing various booming companies that are digital-based businesses. Therefore, we urge the Horn of African countries to internalize these opportunities by swiftly investing in the telecom sector to shift to the online way of doing business. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, digital economy, economic impact, Horn of Africa Identifier An unambiguous reference to the resource within a given context 10.15414/raae.2021.24.01.21-26 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Agriculture https://www.socictopen.socict.org/files/original/6a59ebc08070f4f6c014a4b66fa5ee13.pdf 0eb9c8345f6f113e778ee02b3556cdb0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Food hubs play an essential role in the COVID-19 response in Hawai‘i Creator An entity primarily responsible for making the resource Saleh Azizi Fardkhales, Noa Lincoln Description An account of the resource Community food security and food systems resili­ence have received much emphasis in the last two decades, at least partially in response to mounting challenges and pressures on the global food system. While empirical research shows strong evidence that direct-to-consumer relationships in the food system predominantly serve affluent commu­nities, during the COVID-19 pandemic local food providers have become a necessity through their provision of essential services, such as hunger relief and home deliveries for vulnerable populations. In this paper, we examine the challenges and opportunities of food hubs—innovations in local food systems that help connect small farmers with local markets—during the COVID-19 pandemic using quantitative and qualitative data from practitioners on the ground. The hubs were not necessarily equipped or experienced in the response needed, but they quickly adapted to the situation and demonstrated success during the pandemic, as illustrated by 200–300% growth in performance metrics such as revenues generated, employees retained, customers served, and farmers supported. The performance of the hubs in response to the multiple challenges accompanying the pandemic demonstrates their key role in food system resilience through features of diversity, functional redundancy, and connectivity, suggesting that disaster preparation should consider local food hubs a necessary service. We provide policy suggestions for supporting their role in local food system resilience beyond the pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, resilience, Community Food Systems, hawaii, Hawaiʻi, food hubs Identifier An unambiguous reference to the resource within a given context 10.5304/jafscd.2021.102.036 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture, Environmental sciences, Geography. Anthropology. Recreation, Technology, Social Sciences, Nutrition. Foods and food supply, Recreation. Leisure, Urban groups. The city. Urban sociology, Regional planning, Communities. Classes. Races, Human ecology. Anthropogeography, Home economics https://www.socictopen.socict.org/files/original/37b01d39ade08378df74354fd5fe3d28.pdf 28a0e66e912aebf452b70c0fa2ef4714 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Attenuating the Effects of Novel COVID-19 (SARS-CoV-2) Infection-Induced Cytokine Storm and the Implications. Creator An entity primarily responsible for making the resource Salequl Islam, Dilshad Jahan, Mainul Haque, Siddhartha Dutta, Abdullahi Rabiu Abubakar, Adekunle Babajide Rowaiye, Okiemute Ajiroghene Okpalefe, Olukemi Onuh Adejoke, Joyce Oloaigbe Ogidigo, Oluwakemi Hannah Oladipo, Amoge Chidinma Ogu, Angus Nnamdi Oli, Samson Olofinase, Onyekachi Onyekwere Description An account of the resource The COVID-19 pandemic constitutes an arduous global health challenge, and the increasing number of fatalities calls for the speedy pursuit of a remedy. This review emphasizes the changing aspects of the COVID-19 disease, featuring the cytokine storm's pathological processes. Furthermore, we briefly reviewed potential therapeutic agents that may modulate and alleviate cytokine storms. The literature exploration was made using PubMed, Embase, MEDLINE, Google scholar, and China National Knowledge Infrastructure databases to retrieve the most recent literature on the etiology, diagnostic markers, and the possible prophylactic and therapeutic options for the management of cytokine storm in patients hospitalized with COVID-19 disease. The causative agent, severe acute respiratory coronavirus-2 (SARS-CoV-2), continually threatens the efficiency of the immune system of the infected individuals. As the first responder, the innate immune system provides primary protection against COVID-19, affecting the disease's progression, clinical outcome, and prognosis. Evidence suggests that the fatalities associated with COVID-19 are primarily due to hyper-inflammation and an aberrant immune function. Accordingly, the magnitude of the release of pro-inflammatory cytokines such as interleukin (IL)-1, (IL-6), and tumor necrosis alpha (TNF-α) significantly differentiate between mild and severe cases of COVID-19. The early prediction of a cytokine storm is made possible by several serum chemistry and hematological markers. The prompt use of these markers for diagnosis and the aggressive prevention and management of a cytokine release syndrome is critical in determining the level of morbidity and fatality associated with COVID-19. The prophylaxis and the rapid treatment of cytokine storm by clinicians will significantly enhance the fight against the dreaded COVID-19 disease. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Fatality, SARS-CoV-2, cytokine storm, hyperinflammation Identifier An unambiguous reference to the resource within a given context 10.2147/JIR.S301784 Source A related resource from which the described resource is derived Journal of inflammation research https://www.socictopen.socict.org/files/original/dd387340d594946395965dc209b26410.pdf 452fbbdf6a6bb644560d5ee64f27989a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Percepção de Segurança e Risco de Contágio por Covid-19 Durantes as Vivências de Lazer do Residente do Rio Grande do Norte Creator An entity primarily responsible for making the resource Salete Gonçalves, Rosa Maria Rodrigues Lopes, Michele de Sousa, Tatiana Gehlen Marodin Description An account of the resource O artigo tem como objetivo geral compreender a percepção de segurança e risco de contágio por Covid-19 durante as vivências de lazer do residente do Rio Grande do Norte. E do ponto de vista específico, traçar um panorama da pandemia no estado potiguar; analisar o perfil socioeconômico dos pesquisados; identificar os espaços e vivências de lazer com menor risco de contágio no segundo semestre de 2020. Trata-se de um estudo exploratório, com a utilização de dados primários e secundários e amostra não-probabilística. De forma geral, os resultados apontam que os respondentes se sentem mais seguros em desenvolver atividades em áreas naturais e menos seguros em espaços com capacidade de maior aglomeração de pessoas. Por fim, acredita-se que os protocolos de segurança auxiliarão na confiança e retomadas de determinadas vivências de forma lenta e gradual. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Atividades de Lazer, percepção de segurança e risco de contágio Identifier An unambiguous reference to the resource within a given context 10.35699/2447-6218.2020.25438 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Recreation. Leisure https://www.socictopen.socict.org/files/original/8f74c38c9023912e9e212b9416a1c2e4.pdf 2cd70aea4038a2f03b7b0bf299feb9a6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ilha Grande: simbolismos e mitos que construíram um santuário ecológico Creator An entity primarily responsible for making the resource Salete Rodrigues de Alcântara Description An account of the resource As razões que levam os homens à contemplação da natureza e à constante busca de uma relação harmoniosa com o meio podem ser encontradas a partir da Antigüidade, através de uma Geografia mais imaginária que real. É nesse contexto que vemos o nascimento das idéias a respeito do isolamento que a ilha oferece, representando um refúgio, um ambiente de harmonia e felicidade, enfim, um paraíso a ser preservado. E é nessa linha de pensamento que apresentamos aqui uma tentativa de entender a preocupação em transformar a Ilha Grande, situada no Rio de Janeiro, em nosso santuário ecológico." Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Ilha Grande, Ilhas, ecología, imaginario, mitos Identifier An unambiguous reference to the resource within a given context 10.12957/geouerj.2001.49129 Source A related resource from which the described resource is derived Geo UERJ Publisher An entity responsible for making the resource available Universidade do Estado do Rio de Janeiro Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Geography (General) Relation A related resource <a href="https://www.e-publicacoes.uerj.br/index.php/geouerj/article/view/49129" target="_blank" rel="noreferrer noopener">https://www.e-publicacoes.uerj.br/index.php/geouerj/article/view/49129</a> https://www.socictopen.socict.org/files/original/cfa9ac4cfac0320824241a6f43f09f7c.pdf ee4383876a631dd85636a81f9ab5feb2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource El virus Madariaga le sigue los pasos a los virus Chikungunya y Zika Creator An entity primarily responsible for making the resource Salim Mattar V, Marco González T Description An account of the resource Los virus transmitidos por artrópodos son causa de importantes encefalitis. Varios virus de las encefalitis equinas pertenecen a la familia Togaviridae género Alphavirus, además de Chikungunya y Mayaro, están los virus de la encefalitis del oeste (WEEV), encefalitis equina venezolana (VEEV) y encefalitis equina del este (EEEV). La EEEV se clasificó previamente en cuatro linajes / subtipos distintos (I - IV) (1, 2). Las cepas sudamericanas (SA) (linajes II-IV), que incluyen los aislamientos de América del Sur y Central, son genéticamente diferentes en contraste con las cepas de América del Norte (NA) que pertenecen al linaje I (3). Debido a la divergencia genética y a las diferencias significativas en la ecología y la patogénesis, los aislamientos de América del Sur de EEEV se clasificaron recientemente como una especie distinta la que se denominó virus Madariaga (MADV)(1). Date A point or period of time associated with an event in the lifecycle of the resource 2018 Identifier An unambiguous reference to the resource within a given context 10.21897/rmvz.1480 Source A related resource from which the described resource is derived Revista MVZ Cordoba Publisher An entity responsible for making the resource available Universidad de Cordoba Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Relation A related resource <a href="http://revistas.unicordoba.edu.co/index.php/revistamvz/article/view/1480" target="_blank" rel="noreferrer noopener">http://revistas.unicordoba.edu.co/index.php/revistamvz/article/view/1480</a> https://www.socictopen.socict.org/files/original/17bca2f9783f5ca324b4b0bba595478d.pdf 0a58be27ccd37ad34e66cd65436491d7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource An Intriguing Case of Pneumoperitoneum In a Patient With COVID-19: Do All Pneumoperitoneum Cases Need Surgery? Creator An entity primarily responsible for making the resource Salim Surani, Munish Sharma, Pratima Ojha, Pahnwat T Taweesedt, Iqbal Ratnani Description An account of the resource Pneumoperitoneum is pneumatosis in the potential space of the abdominal cavity. It is generally considered a surgical emergency and is mostly due to perforated hollow viscus. Rarely, pneumoperitoneum might occur even in the absence of bowel perforation. We hereby present a case of pneumoperitoneum in a patient with COVID-19 pneumonia and pneumomediastinum, which was managed non-surgically. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Pneumomediastinum, Pneumoperitoneum, Tube thoracostomy Identifier An unambiguous reference to the resource within a given context 10.7759/cureus.12279 Source A related resource from which the described resource is derived Cureus https://www.socictopen.socict.org/files/original/9279ea54260dcfe915c6340c8ee8c19f.pdf b7c2d41aa71c637e449cc88ef5b278d7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Lasers use in dermatology practice in the evolving COVID-19 scenario: Recommendations by SIG lasers (IADVL academy) Creator An entity primarily responsible for making the resource Salim Thurakkal, Abhishek De, Swapnil Shah, Sunil Trivedi, David Pudukadan, Sachin Dhawan, Pradeep Kumari, Anuj Pall, Ekta Romi, K Jyothy, M D Selvam, Sahil Mrigpuri Description An account of the resource The COVID-19 pandemic has taken the entire world by storm. Almost all dermatology laser procedures are considered non-essential and there is a consensus that they should be deferred till the threat of the COVID-19 is well and truly over. The article presents recommendations for the use of lasers and energy based devices in a safe manner during and in the immediate aftermath of COVID-19 pandemic. Plume generating procedures need full personal protective equipment to be used. Special precautions are required for specific laser and energy based procedures. A robust disinfection strategy based on preventing fomite borne COVID-19 transmission in the laser operating room is essential. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource safety, lasers, Pandemic, personal protective equipment, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.4103/idoj.IDOJ_239_20 Source A related resource from which the described resource is derived Indian Dermatology Online Journal Publisher An entity responsible for making the resource available Wolters Kluwer Medknow Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Dermatology https://www.socictopen.socict.org/files/original/6eafc3ea03945b3e83811f631f405313.pdf 32f2c9639a0366cd4bd1d077e2e69e62 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Vaccines: Underlying Principles of Design and Testing. Creator An entity primarily responsible for making the resource Sallay Kallon, Shahryar Samir, Nilu Goonetilleke Description An account of the resource In this paper, we review the key elements that should be considered to take a novel vaccine from the laboratory through to licensure in the modern era. This paper is divided into four sections. First, we discuss the host immune responses that we engage with vaccines. Second, we discuss how in vivo and in vitro studies can inform vaccine design. Third, we discuss different vaccine modalities that have been licensed or are in testing in humans. Last, we overview the basic principles of vaccine approvals. Throughout we provide real-world examples of vaccine development against infectious diseases, including coronavirus disease 2019 (COVID-19). Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1002/cpt.2207 Source A related resource from which the described resource is derived Clinical pharmacology and therapeutics