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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Use of non-invasive ventilation in acute respiratory failure due to SARS-CoV-2 pneumonia: typing of patients and choice of respiratory support, the role of internal medicine</text>
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                <text>Federico Lari, Fabrizio Giostra, Stefania Guerrini</text>
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                <text>The use of non-invasive ventilation (NIV) during de novo acute hypoxemic respiratory failure is not recommended by the guidelines because NIV does not improve the prognosis. With the advent of the new coronavirus, many cases of acute hypoxemic respiratory failure associated with the infection (severe acute respiratory infection) have been observed: data are missing regarding the use of NIV in this particular clinical condition, but a correct typing of patients based on different clinical, pathophysiological and radiological characteristics, could help in prognostic stratification and in the choice of respiratory support (invasive versus non-invasive). During NIV in these patients particular attention is paid to the possibility of environmental dissemination of the virus and consequently adequate technical precautions are taken.</text>
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                <text>2020</text>
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                <text>acute respiratory failure, Noninvasive ventilation, SARS-CoV-2</text>
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                <text>DOI: 10.4081/itjm.2020.1309</text>
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                <text>Italian Journal of Medicine</text>
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                <text>Medicine</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Use of peritoneal dialysis for acute kidney injury during the COVID-19 pandemic in New York City: a multicenter observational study.</text>
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                <text>Wei Chen, Nina Caplin, Osama El Shamy, Shuchita Sharma, Maryanne Y Sourial, Michael J Ross, Mina H Sourial, Kalyan Prudhvi, Ladan Golestaneh, Vesh Srivatana, Rochelle Dalsan, Daniil Shimonov, Luis Sanchez-Russo, Sara Atallah, Jaime Uribarri</text>
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                <text>To demonstrate feasibility of acute peritoneal dialysis (PD) for acute kidney injury during the coronavirus disease 2019 (COVID-19) pandemic, we performed a multicenter, retrospective, observational study of 94 patients who received acute PD in New York City in the spring of 2020. Patient comorbidities, severity of disease, laboratory values, kidney replacement therapy, and patient outcomes were recorded. The mean age was 61 ± 11 years; 34% were women; 94% had confirmed COVID-19; 32% required mechanical ventilation on admission. Compared to the levels prior to initiation of kidney replacement therapy, the mean serum potassium level decreased from 5.1 ± 0.9 to 4.5 ± 0.7 mEq/L on PD day 3 and 4.2 ± 0.6 mEq/L on day 7 (P &lt; 0.001 for both); mean serum bicarbonate increased from 20 ± 4 to 21 ± 4 mEq/L on PD day 3 (P = 0.002) and 24 ± 4 mEq/L on day 7 (P &lt; 0.001). After a median follow-up of 30 days, 46% of patients died and 22% had renal recovery. Male sex and mechanical ventilation on admission were significant predictors of mortality. The rapid implementation of an acute PD program was feasible despite resource constraints and can be lifesaving during crises such as the COVID-19 pandemic.</text>
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                <text>2021</text>
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                <text>mortality, covid-19, acute kidney injury, kidney replacement therapy, Acute peritoneal dialysis</text>
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                <text>10.1016/j.kint.2021.04.017</text>
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                <text>Kidney international</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
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                <text>Use of Plasma Therapy for Severe Fever with Thrombocytopenia Syndrome Encephalopathy</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="17252">
                <text>Se Yoon Park, Woo Young Choi, Yong Pil Chong, Sun-Whan Park, Eun Byeol Wang, Won-Ja Lee, Youngmee Jee, Seog-Woon Kwon, Sunghan Kim</text>
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            <name>Date</name>
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                <text>2016</text>
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                <text>Severe fever with thrombocytopenia syndrome, encephalopathy, Plasmapheresis, investigational therapies, Viruses, Republic of Korea</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="17255">
                <text>DOI: 10.3201/eid2207.151791</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                <text>EN</text>
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        <src>https://www.socictopen.socict.org/files/original/5ea8bb6b2059809a9517e54dccd9334d.pdf</src>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Use of powered air-purifying respirator (PAPR) by healthcare workers for preventing highly infectious viral diseases—a systematic review of evidence</text>
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            <name>Creator</name>
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              <elementText elementTextId="45364">
                <text>Ana Licina, Andrew Silvers, Rhonda L. Stuart</text>
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                <text>Abstract Background Healthcare workers (HCWs) are at particular risk during pandemics and epidemics of highly virulent diseases with significant morbidity and case fatality rate. These diseases include severe acute respiratory syndrome coronaviruses, SARS-CoV-1 and SARS-CoV-2, Middle Eastern Respiratory Syndrome (MERS), and Ebola. With the current (SARS-CoV-2) global pandemic, it is critical to delineate appropriate contextual respiratory protection for HCWs. The aim of this systematic review was to evaluate the effect of powered air-purifying respirators (PAPRs) as part of respiratory protection versus another device (egN95/FFP2) on HCW infection rates and contamination. Methods Our primary outcomes included HCW infection rates with SARS-CoV-2, SARS-CoV-1, Ebola, or MERS when utilizing PAPR. We included randomized controlled trials, non-randomized controlled trials, and observational studies. We searched the following databases: MEDLINE, EMBASE, and Cochrane Library (Cochrane Database of Systematic Reviews and CENTRAL). Two reviewers independently screened all citations, full-text articles, and abstracted data. Due to clinical and methodological heterogeneity, we did not conduct a meta-analysis. Where applicable, we constructed evidence profile (EP) tables for each individual outcome. Confidence in cumulative evidence for each outcome was classified according to the GRADE system. Results We identified 689 studies during literature searches. We included 10 full-text studies. A narrative synthesis was provided. Two on-field studies reported no difference in the rates of healthcare workers performing airway procedures during the care of critical patients with SARS-CoV-2. A single simulation trial reported a lower level of cross-contamination of participants using PAPR compared to alternative respiratory protection. There is moderate quality evidence that PAPR use is associated with greater heat tolerance but lower scores for mobility and communication ability. We identified a trend towards greater self-reported wearer comfort with PAPR technology in low-quality observational simulation studies. Conclusion Field observational studies do not indicate a difference in healthcare worker infection utilizing PAPR devices versus other compliant respiratory equipment. Greater heat tolerance accompanied by lower scores of mobility and audibility in PAPR was identified. Further pragmatic studies are needed in order to delineate actual effectiveness and provider satisfaction with PAPR technology. Systematic review registration The protocol for this review was prospectively registered with the International Register of Systematic Reviews identification number CRD42020184724 .</text>
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                <text>2020</text>
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                <text>healthcare worker, SARS-CoV-2, SARS-CoV-1, Respiratory protection, Powered air-purifying respirator</text>
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              <elementText elementTextId="45368">
                <text>10.1186/s13643-020-01431-5</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Biotemas</text>
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              <elementText elementTextId="45370">
                <text>Universidade Federal de Santa Catarina</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Use of protease inhibitors for the prevention of COVID-19.</text>
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                <text>Tomoya Sagawa, Ken-Ichiro Inoue, Hirohisa Takano</text>
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                <text>Preventive medicine</text>
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                <text>Elsa Lamy, Pía López-Jornet, Fernando Capela e Silva, Asta Tvarijonaviciute, Jose J. Ceron, Silvia Martínez-Subiela, Peter David Eckersall</text>
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                <text>In this report, updated information and future perspectives about the use of saliva as a sample for laboratory analysis of the Covid-19 are highlighted. Saliva can be used for the direct detection of the SARS-CoV-2 virus, the quantification of the specific immunoglobulins produced against it, and for the evaluation of the non-specific, innate immune response of the patient. Moreover, a deeper knowledge of potential changes in the saliva proteome in this disease may allow the identification of new diagnostic and prognostic biomarkers, or even help our understanding of the mechanisms associated with the disease. With the development of appropriate sample collection and processing methods and the use of adequate assays, saliva can provide useful clinical information about the disease and could be potentially included in guidelines for sample collection for the diagnosis, disease management, and control of Covid-19.</text>
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                <text>DOI: 10.3390/jcm9051491</text>
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                <text>Journal of Clinical Medicine</text>
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                <text>Use of SARS-CoV-2 genomes to estimate the effective reproductive number (Rt) in Peru during March – April 2020</text>
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                <text>Pedro E. Romero, Milagros Sánchez-Yupari, Stephanie Montero, Pablo Tsukayama</text>
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                <text>The understanding of COVID-19, caused by the SARS-CoV-2, is essential to improve evidence-based public health policies. The effective reproductive number (Rt) in Peru was estimated using information from 113 complete genomes sequenced by the Instituto Nacional de Salud del Perú (INS), available in the GISAID public database. The Rt trend during March and April of 2020 was found to be similar to results from other epidemiological reports. The Rt decreased during the first two weeks of March. Its lowest value was reported during the week after the quarantine began. The Rt increased moderately after the second week of April. The implication of early decisions taken to mitigate the transmission are discussed. Genomic surveillance will be necessary to understand the transmission and evolution of SARS-CoV-2 in Peru, and will complement the epidemiological information.</text>
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                <text>Modelos Epidemiológicos, Peru, SARS-CoV-2, Vigilância, análisis bayesiano, bases de datos de ácidos nucleicos, covid-19, epidemiologia molecular, filogenómica, genómica</text>
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                <text>10.17843/rpmesp.2021.382.6417</text>
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                <text>Revista Peruana de Medicina Experimental y Salud Pública</text>
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                <text>Instituto Nacional de Salud</text>
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                <text>&lt;a href="https://rpmesp.ins.gob.pe/rpmesp/article/view/6417" target="_blank" rel="noreferrer noopener"&gt;https://rpmesp.ins.gob.pe/rpmesp/article/view/6417&lt;/a&gt;</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Use of the FebriDx point-of-care test for the exclusion of SARS-CoV-2 diagnosis in a population with acute respiratory infection during the second (COVID-19) wave in Italy.</text>
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                <text>Lorenzo Menicacci, Alessandro Morettini, Filippo Lagi, Sasha Trevisan, Matteo Piccica, Lucia Graziani, Gregorio Basile, Jessica Mencarini, Beatrice Borchi, Micol Vaudo, Valentina Scotti, Alessia Fabbri, Giulia Bandini, Camilla Tozzetti, Andrea Berni, Noemi Aiezza, Giulia Pestelli, Valerio Turchi, Alberto Moggi Pignone, Loredana Poggesi, Carlo Nozzoli, Gian Maria Rossolini, Alessandro Bartoloni</text>
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                <text>Evaluate the real-world accuracy of Myxovirus resistance protein A (MxA) detected by the rapid, point-of-care FebriDx test during the second-wave pandemic in Italy in patients with acute respiratory infection (ARI) and a clinical suspicion of COVID-19. Prospective, observational, diagnostic accuracy study whereby hospitalized patients with ARI were consecutively enrolled in a single tertiary care center in Italy from August 1, 2020 to January 31, 2021. COVID-19 was diagnosed in 136/200 (68.0%) patients and Non-COVID-19 was diagnosed in64/200 (32.0%) patients. COVID-19 patients were younger and had a lower Charlson comorbidity index compared to non-COVID-19 patients (p &lt; 0.001). Concordance between FebriDx, MxA and rt-PCR for SARS-CoV-2 (gold standard) was good (k 0.93, 95%CI 0.87-0.99). Overall sensitivity and specificity were 97.8% [95%CI 93.7-99.5] and 95.3% [95%CI 86.9%-99.0%], respectively. FebriDx demonstrated a negative predictive value of 95.3% (95%CI 86.9-99.0) for an observed disease prevalence of 68%. FebriDx MxA showed high diagnostic accuracy to identify COVID-19 and could be considered as a real-time triage tool to streamline the management of suspected COVID-19 patients. FebriDx also detected bacterial etiology in non-COVID-19 patients suggesting good performance to distinguish bacterial from viral respiratory infection.</text>
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                <text>2021</text>
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                <text>covid-19, Italy, Accuracy, point-of-care, FebriDx</text>
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                <text>10.1016/j.ijid.2021.04.065</text>
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                <text>International Journal of Infectious Diseases</text>
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                <text>Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target [version 3; peer review: 2 approved]</text>
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                <text>Slobodan Paessler, Veljko Veljkovic, Júlia Vergara-Alert, Joaquim Segalés</text>
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                <text>A novel coronavirus recently identified in Wuhan, China (SARS-CoV-2) has expanded the number of highly pathogenic coronaviruses affecting humans. The SARS-CoV-2 represents a potential epidemic or pandemic threat, which requires a quick response for preparedness against this infection. The present report uses the informational spectrum methodology to identify the possible origin and natural host of the new virus, as well as putative therapeutic and vaccine targets. The performed in silico analysis indicates that the newly emerging SARS-CoV-2 is closely related to severe acute respiratory syndrome (SARS)-CoV and, to a lesser degree, Middle East respiratory syndrome (MERS)-CoV. Moreover, the well-known SARS-CoV receptor (ACE2) might be a putative receptor for the novel virus as well. Actin protein was also suggested as a host factor that participates in cell entry and pathogenesis of SARS-CoV-2; therefore, drugs modulating biological activity of this protein (e.g. ibuprofen) were suggested as potential candidates for treatment of this viral infection. Additional results indicated that civets and poultry are potential candidates for the natural reservoir of the SARS-CoV-2, and that domain 288-330 of S1 protein from the SARS-CoV-2 represents promising therapeutic and/or vaccine target.</text>
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                <text>DOI: 10.12688/f1000research.22149.3</text>
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                <text>F1000 Research Ltd</text>
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                <text>Biology (General), Medicine</text>
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            <name>Title</name>
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                <text>Use of triiodothyronine to treat critically ill COVID-19 patients: a new clinical trial</text>
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            <name>Creator</name>
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                <text>Constantinos Pantos, Iordanis Mourouzis, Ioulia Tseti</text>
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            <name>Date</name>
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                <text>2020</text>
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            <name>Identifier</name>
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                <text>DOI: 10.1186/s13054-020-02934-2</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Critical Care</text>
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            <name>Publisher</name>
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                <text>BMC</text>
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                <text>Medical emergencies. Critical care. Intensive care. First aid</text>
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