2021 10 20655 https://www.socictopen.socict.org/files/original/40685baf20f5b5fa8152d345d7da0d9e.pdf 2feb4c8db2ed0e5b1ddb0cae789b5c37 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Detection of Feline Coronavirus in Feline Effusions by Immunofluorescence Staining and Reverse Transcription Polymerase Chain Reaction Creator An entity primarily responsible for making the resource Yi-Chen Luo, I-Li Liu, Yu-Tan Chen, Hui-Wen Chen Description An account of the resource Feline coronavirus (FCoV), the pathogen for feline infectious peritonitis, is a lethal infectious agent that can cause effusions in the pleural and abdominal cavities in domestic cats. To study the epidemiology of FCoV in Taiwan, 81 FIP-suspected sick cats with effusive specimens were recruited to test for FCoV infection using immunofluorescence staining and reverse transcription-polymerase chain reaction as detection methods, and viral RNAs were recovered from the specimens to conduct genotyping and phylogenetic analysis based on the spike (S) protein gene. The results revealed that a total of 47 (47/81, 58%) of the sick cats were positive for FCoV in the effusion samples, of which 39 were successfully sequenced and comprised of 21 type I strains, 9 type II strains, and 9 co-infections. The signalment analysis of these sick cats revealed that only the sex of cats showed a significant association (odds ratio = 2.74, 95% confidence interval = 1.06–7.07, p = 0.03) with the infection of FCoV, while age and breed showed no association. FCoV-positive cats demonstrated a significantly lower albumin to globulin ratio than negative individuals (p = 0.0004). The partial S gene-based phylogenetic analysis revealed that the type I strains demonstrated genetic diversity forming several clades, while the type II strains were more conserved. This study demonstrates the latest epidemiological status of FCoV infection in the northern part of Taiwan among sick cats and presents comparisons of Taiwan and other countries. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource phylogenetic analysis, feline coronavirus, genotyping, Immunofluorescence staining, spike protein gene Identifier An unambiguous reference to the resource within a given context 10.3390/pathogens9090698 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/6adb7644f5e459de2bc387f29b5ad70f.pdf dd6d37a76d4d4d0b7751504d1b6c5138 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource An investor's perspective on infectious diseases and their influence on market behavior Creator An entity primarily responsible for making the resource Yi-Hsien Wang, Fu-Ju Yang, Li-Je Chen Description An account of the resource Recently, increasing number of infectious diseases has swept the world. The outbreak of a contagious disease not only affects the health and lives of people but also causes economic growth to stagnate. Business in the biotechnology industry is closely related to infectious diseases but what exactly is the information value of the outbreak of infectious disease on biotechnology? This study investigates how such outbreaks can affect the performance of biotechnology stocks. In the past 10 years, major statutory infectious diseases in Taiwan have included ENTEROVIRUS 71, DENGUE FEVER, SARS and H1N1. The empirical results indicate that there is a significant abnormal return on company shares in Taiwan's biotechnology industry because of statutory infectious epidemics. The relationship between the financial ratios of biotechnology companies and abnormal returns was analyzed as part of this research. The results show that the influence on R&D ratios, current ratios and assets are significant. Empirical findings reveal that the investors rationally measure operating conditions of the biotechnology companies during outbreaks of major infectious disease and adjust portfolio allocation accordingly. Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource biotechnology industry, infectious diseases, investor's perspective, Abnormal Returns, stock performance, risk factor Identifier An unambiguous reference to the resource within a given context DOI: 10.3846/16111699.2012.711360 Source A related resource from which the described resource is derived Journal of Business Economics and Management Publisher An entity responsible for making the resource available Vilnius Gedinimas Technical University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Business Language A language of the resource EN https://www.socictopen.socict.org/files/original/a0095ebbfb048e9991d0c28a4dbd0e2c.pdf 5ef525ed56b08aa41bf5f0bb3830f481 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A simple rule for interpreting COVID-19 antibody test results, by seroprevalence and vaccination status. Creator An entity primarily responsible for making the resource Yi-Hsuan Chen, Chi-Tai Fang Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1016/j.jmii.2021.02.008 Source A related resource from which the described resource is derived Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi https://www.socictopen.socict.org/files/original/974c5abb4f2ed5db5d8312a783bd79fd.pdf 9d51687d046e311e7c0417363c987e7d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling Creator An entity primarily responsible for making the resource Yi-Hsuan Wu, Daniel Tsun-Yee Chiu, Hsin-Ru Lin, Hsiang-Yu Tang, Mei-Ling Cheng, Hung-Yao Ho Description An account of the resource Glucose-6-phosphate dehydrogenase (G6PD)-deficient cells are highly susceptible to viral infection. This study examined the mechanism underlying this phenomenon by measuring the expression of antiviral genes—tumor necrosis factor alpha (TNF-α) and GTPase myxovirus resistance 1 (MX1)—in G6PD-knockdown cells upon human coronavirus 229E (HCoV-229E) and enterovirus 71 (EV71) infection. Molecular analysis revealed that the promoter activities of TNF-α and MX1 were downregulated in G6PD-knockdown cells, and that the IκB degradation and DNA binding activity of NF-κB were decreased. The HSCARG protein, a nicotinamide adenine dinucleotide phosphate (NADPH) sensor and negative regulator of NF-κB, was upregulated in G6PD-knockdown cells with decreased NADPH/NADP+ ratio. Treatment of G6PD-knockdown cells with siRNA against HSCARG enhanced the DNA binding activity of NF-κB and the expression of TNF-α and MX1, but suppressed the expression of viral genes; however, the overexpression of HSCARG inhibited the antiviral response. Exogenous G6PD or IDH1 expression inhibited the expression of HSCARG, resulting in increased expression of TNF-α and MX1 and reduced viral gene expression upon virus infection. Our findings suggest that the increased susceptibility of the G6PD-knockdown cells to viral infection was due to impaired NF-κB signaling and antiviral response mediated by HSCARG. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource G6PD, NAD(P)H, coronavirus, Enterovirus, antiviral response, HSCARG Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v7122966 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/4fa1e13a08842e286784cea7ace2c8da.pdf 3036d1e57eef1ed38428125774b3b05f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Entry of <i>Scotophilus</i> Bat Coronavirus-512 and Severe Acute Respiratory Syndrome Coronavirus in Human and Multiple Animal Cells Creator An entity primarily responsible for making the resource Yi-Ning Chen, Hsiao-Chin Hsu, Shengwei Wang, Hao-Chiang Lien, Hsin-Ti Lu, Sheng-Kai Peng Description An account of the resource Bats are natural reservoirs of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV). Scotophilus bat CoV-512 demonstrates potential for cross-species transmission because its viral RNA and specific antibodies have been detected in three bat species of Taiwan. Understanding the cell tropism of Scotophilus bat CoV-512 is the first step for studying the mechanism of cross-species transmission. In this study, a lentivirus-based pseudovirus was produced using the spike (S) protein of Scotophilus bat CoV-512 or SARS-CoV as a surface protein to test the interaction between coronaviral S protein and its cell receptor on 11 different cells. Susceptible cells expressed red fluorescence protein (RFP) after the entry of RFP-bound green fluorescence protein (GFP)-fused S protein of Scotophilus bat CoV-512 (RFP-Sco-S-eGFP) or RFP-SARS-S pseudovirus, and firefly luciferase (FLuc) activity expressed by cells infected with FLuc-Sco-S-eGFP or FLuc-SARS-S pseudovirus was quantified. Scotophilus bat CoV-512 pseudovirus had significantly higher entry efficiencies in Madin Darby dog kidney epithelial cells (MDCK), black flying fox brain cells (Pabr), and rat small intestine epithelial cells (IEC-6). SARS-CoV pseudovirus had significantly higher entry efficiencies in human embryonic kidney epithelial cells (HEK-293T), pig kidney epithelial cells (PK15), and MDCK cells. These findings demonstrated that Scotophilus bat CoV-512 had a broad host range for cross-species transmission like SARS-CoV. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource <i>scotophilus</i> bat coronavirus-512, severe acute respiratory syndrome coronavirus, Pseudovirus, Cell receptor Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/pathogens8040259 Source A related resource from which the described resource is derived Pathogens Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/a5e6a4450d80449c5b7c6660fdc6c6ad.pdf 0a1f7bbd6c10c51678555a3b96ac22d1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antiviral Activity of Graphene–Silver Nanocomposites against Non-Enveloped and Enveloped Viruses Creator An entity primarily responsible for making the resource Yi-Ning Chen, Yi-Huang Hsueh, Chien-Te Hsieh, Dong-Ying Tzou, Pai-Ling Chang Description An account of the resource The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and biocompatibility. No studies on the antiviral activity of nanomaterials on non-enveloped viruses have been reported. To investigate the antiviral activity of graphene oxide (GO) sheets and GO sheets with silver particles (GO-Ag) against enveloped and non-enveloped viruses, feline coronavirus (FCoV) with an envelope and infectious bursal disease virus (IBDV) without an envelope were chosen. The morphology and sizes of GO and GO-Ag were characterized by transmission, scanning electron microscopy, and X-ray diffraction. A virus inhibition assay was used to identify the antiviral activity of GO and GO-Ag. Go-Ag inhibited 25% of infection by FCoV and 23% by IBDV, whereas GO only inhibited 16% of infection by FCoV but showed no antiviral activity against the infection by IBDV. Further application of GO and GO-Ag can be considered for personal protection equipment to decrease the transmission of viruses. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource graphene oxide, silver nanoparticle, Feline coronavirus, infectious bursal disease virus, enveloped virus, non-enveloped virus Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ijerph13040430 Source A related resource from which the described resource is derived International Journal of Environmental Research and Public Health Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/1c08a5606bb6c856a3ef91be02547553.pdf e4dfab52c14dfc1f271ce075a2441929 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Practical Impacts of Exercise-Intervention on COVID-19 Pandemic Creator An entity primarily responsible for making the resource Yi-Sub Kwak, Jin-Gu Ji, Kwi Baek Kim Description An account of the resource Abstracts Purpose Coronavirus-19 (COVID-19) was first reported in China at the end of 2019. COVID-19 infected people increased and spreads COVID-19 rapidly across the globe. Finally, this outbreak turn into a pandemic and yields national crisis and finally to endemic. Most individual are exposed to stressful situation because of unknown duration of COVID-19. Most of all, smoking, obesity, metabolic syndromes, lowered immunity such as decreased natural killer (NK) cell, T cell activity were significantly correlated with the COVID-19 incidence. However, all this variables were concerned with exercise habit and exercise-intervention, therefore, the present study aimed to assess the relationship between COVID-19 incidence and physical activity status. Methods PubMed database was searched from December 2019 to August 2020 using predefined search terms “COVID-19”, “exercise”, and “immunity”.Based on reference search, more than 65 articles were identified whereas 50 papers (36 references) met the inclusion criteria and were well connected with COVID-19 and physical exercise with immunity. We analyzed the connections between exercise and COVID-19 with many variables, and dealtabout COVID-19 prevention and exercise-intervention programs in the main text. Results & Conclusions Smoking, obesity, metabolic syndromes, reduced respiratory muscle mass, lowered immunity such as decreased natural killer cell and T cell activity were significantly correlated with the COVID-19 infection. However, all this variables were also concerned with exercise habit and exercise-intervention. Regular physical activity have shown to be an effective prescription for obesity, many metabolic syndromes and good immunity. However, physical inactivity and chronic metabolic syndromes were associated with reduced immunity such as reduced NK cell activity, uncontrolled T cell immunity, decreased respiratory immunity and even URTIs (upper respiratory track infection) for elite athletes. Multicomponent exercise program is considered especially for the elderly people, 5 days per week, 40-60% HRR (heart rate reserve) intensity, and 150-300 minutes aerobic and resistance training (200–400 minutes/week under the quarantine period) were recommended. Moreover, all form of psychological support also to increase immunity against COVID-19. More mechanism studies are urgently needed to determine which mode and which duration exercises are best most suited, and effective for prevention and treatment of COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource immunity, covid-19, exercise intervention, urtis Identifier An unambiguous reference to the resource within a given context 10.15857/ksep.2020.29.4.339 Source A related resource from which the described resource is derived 운동과학 Publisher An entity responsible for making the resource available The Korean Society of Exercise Physiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biochemistry, Nutrition. Foods and food supply https://www.socictopen.socict.org/files/original/acc17f04dc137b041f33d5795a4be09b.pdf 86d82018cd8d8d18b59b4464f8f9bfd8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Dynamic Response Systems of Healthcare Mask Production to COVID-19: A Case Study of Korea Creator An entity primarily responsible for making the resource Yi-Yu Chen, EunSu Lee, Melanie McDonald, Erin O’Neill Description An account of the resource Korea initiated a new experiment, called a dynamic response system for open democratic societies as a principle to respond to the novel coronavirus (COVID-19). The global pandemic of COVID-19 led to a surge in demand for healthcare medical masks and respirators, and strained the global supply chain of mask production and distribution systems. This study provides a systemic view of critical personal protective equipment for both healthcare staff and the public to stop the spread of COVID-19. This study investigates the dynamic response system of healthcare mask production to the coronavirus and discusses lessons learned in view of systems thinking. The study shows that it is critical to developing a quick and dynamic response system to the evolving market conditions with flexible and agile operations. Visibility with transparency with information sharing with the public is also critical under global pandemic. Due to the shortage of mask supply, smart consumption is required along with collaboration with public and private sectors, as well as global organizations. Democratic leadership and a well-prepared strategic plan for long-term period are essential to the open society to prepare the global pandemic in the future. This study serves as a benchmark for dynamic and timely responses to the global pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource systems thinking, production capacity, Pandemic, demand management, COVID-19, dynamic response systems Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/systems8020018 Source A related resource from which the described resource is derived Systems Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Technology (General), Systems engineering https://www.socictopen.socict.org/files/original/72020760c2169e257af36857b60f8108.pdf 20c5ebde57b8dc7759b5ab8489c0c812 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Sources of Care Stress of Nursing Staff for Patients with Infectious Diseases during the Prevalence of COVID-19: A Case Study of Some Regional Teaching Hospitals in Southern Taiwan Creator An entity primarily responsible for making the resource Yichao Huang, Lichen Yu Description An account of the resource (1) Background: The COVID-19 epidemic had caused more than 100 million confirmed cases worldwide by the end of January 2021. The focus of this study was to explore which stress was felt the most by nursing staff in isolation wards in the face of dangerous infectious diseases. (2) Methods: Nursing staff in negative pressure isolation wards were taken as the research objects. The sources of stress were divided into 14 items in three categories, namely, patient care, infection protection, and support system, and the questionnaire results were ranked by a Gaussian curve. (3) Results: Even during the COVID-19 epidemic, nurses in isolation wards still consider that the clinical symptoms of patients in isolation wards cannot be closely tracked as the primary consideration. (4) Conclusions: During the epidemic period, the ability and confidence of nursing staff were strengthened through education and training, and their chances of infection were reduced through comprehensive vaccination and the improvement of protective equipment. In the face of the unstable mood of patients and their families due to isolation, more protective measures should be prepared for nursing staff. In order to relieve the stress, supervisors can adjust the nursing manpower timely according to the difficulty and risk of patient care to reduce the care stress. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, negative pressure isolation ward, Gaussian curve, care stress Identifier An unambiguous reference to the resource within a given context 10.3390/healthcare9040462 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/1fda7684ebca93a4e3afaccd85258d50.pdf 0d21522761557e3fa206529f536703d3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Containment, Contact Tracing and Asymptomatic Transmission of Novel Coronavirus Disease (COVID-19): A Modelling Study Creator An entity primarily responsible for making the resource Yichi Yang, Takeshi Miyama, Andrei R. Akhmetzhanov, Ryo Kinoshita, Asami Anzai, Sung-mok Jung, Natalie M Linton, Tetsuro Kobayashi, Katsuma Hayashi, Ayako Suzuki, Hiroshi Nishiura Description An account of the resource When a novel infectious disease emerges, enhanced contact tracing and isolation are implemented to prevent a major epidemic, and indeed, they have been successful for the control of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), which have been greatly reduced without causing a global pandemic. Considering that asymptomatic and pre-symptomatic infections are substantial for the novel coronavirus disease (COVID-19), the feasibility of preventing the major epidemic has been questioned. Using a two-type branching process model, the present study assesses the feasibility of containing COVID-19 by computing the probability of a major epidemic. We show that if there is a substantial number of asymptomatic transmissions, cutting chains of transmission by means of contact tracing and case isolation would be very challenging without additional interventions, and in particular, untraced cases contribute to lowering the feasibility of containment. Even if isolation of symptomatic cases is conducted swiftly after symptom onset, only secondary transmissions after the symptom onset can be prevented. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource epidemiology, emerging infectious diseases, Containment, Asymptomatic Identifier An unambiguous reference to the resource within a given context 10.3390/jcm9103125 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine