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Strengthening epidemiologic investigation of infectious diseases in Korea: lessons from the Middle East Respiratory Syndrome outbreak
The recent outbreak of Middle East Respiratory Syndrome (MERS) coronavirus infection in Korea resulted in large socioeconomic losses. This provoked the Korean government and the general public to recognize the importance of having a well-established…
Position: 8703 (27 views)
Mechanism of nucleic acid unwinding by SARS-CoV helicase.
The non-structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a helicase that separates double-stranded RNA (dsRNA) or DNA (dsDNA) with a 5' → 3' polarity, using the energy of nucleotide hydrolysis. We…
Position: 7360 (29 views)
Mild Encephalitis with a Reversible Splenial Lesion (MERS) Accompanied by Myelitis: A Case Report
Background: Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) can present with various manifestations of central nervous system (CNS) dysfunction. However, MERS with myelitis has rarely been reported. We reported a case of…
Position: 4290 (37 views)
Systematic artifacts in support vector regression-based compound potency prediction revealed by statistical and activity landscape analysis.
Support vector machines are a popular machine learning method for many classification tasks in biology and chemistry. In addition, the support vector regression (SVR) variant is widely used for numerical property predictions. In chemoinformatics and…
Position: 8703 (27 views)
The nucleocapsid protein of human coronavirus NL63.
Human coronavirus (HCoV) NL63 was first described in 2004 and is associated with respiratory tract disease of varying severity. At the genetic and structural level, HCoV-NL63 is similar to other members of the Coronavirinae subfamily, especially…
Position: 7360 (29 views)
Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update.
The emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infections has become a global issue of dire concerns. MERS-CoV infections have been identified in many countries all over the world whereas high level occurrences have been…
Position: 5173 (34 views)
Tailoring subunit vaccine immunity with adjuvant combinations and delivery routes using the Middle East respiratory coronavirus (MERS-CoV) receptor-binding domain as an antigen.
The development of an effective vaccine is critical for prevention of a Middle East respiratory syndrome coronavirus (MERS-CoV) pandemic. Some studies have indicated the receptor-binding domain (RBD) protein of MERS-CoV spike (S) is a good candidate…
Position: 12068 (23 views)
CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory syndrome coronavirus (MERS-CoV) infection and evolution of persistent infection.
Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently isolated betacoronavirus identified as the etiologic agent of a frequently fatal disease in Western Asia, Middle East respiratory syndrome. Attempts to identify the natural…
Position: 5881 (32 views)
A multi-method approach to curriculum development for in-service training in China's newly established health emergency response offices.
To describe an innovative approach for developing and implementing an in-service curriculum in China for staff of the newly established health emergency response offices (HEROs), and that is generalisable to other settings.The multi-method training…
Position: 11136 (24 views)
Is there still room for novel viral pathogens in pediatric respiratory tract infections?
Viruses are the most frequent cause of respiratory disease in children. However, despite the advanced diagnostic methods currently in use, in 20 to 50% of respiratory samples a specific pathogen cannot be detected. In this work, we used a metagenomic…
Position: 8703 (27 views)