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Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia.
This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and…
Position: 5929 (32 views)
Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.
The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) mediates viral entry into target cells. Cleavage and activation of SARS S by a host cell protease is essential for infectious viral entry and the responsible enzymes…
Position: 10268 (25 views)
Non-esterified fatty acids generate distinct low-molecular weight amyloid-β (Aβ42) oligomers along pathway different from fibril formation.
Amyloid-β (Aβ) peptide aggregation is known to play a central role in the etiology of Alzheimer's disease (AD). Among various aggregates, low-molecular weight soluble oligomers of Aβ are increasingly believed to be the primary neurotoxic agents…
Position: 9472 (26 views)
Identification and mapping of linear antibody epitopes in human serum albumin using high-density Peptide arrays.
We have recently developed a high-density photolithographic, peptide array technology with a theoretical upper limit of 2 million different peptides per array of 2 cm(2). Here, we have used this to perform complete and exhaustive analyses of linear B…
Position: 7401 (29 views)
Middle East respiratory syndrome coronavirus (MERS Cov) outbreak so far exempted Sub Saharan Africa; is it good news or call for action?
The reported cases of MERS Cov in Arabian Peninsula and sporadic caseselsewhere except in sub Saharan Africa at present is disquieting considering itsinitial clinical feature that mimic flu like symptoms caused by other viruses.However MERS Cov is…
Position: 6866 (30 views)
Cathepsin L Helps to Defend Mice from Infection with Influenza A.
Host-derived proteases can augment or help to clear infections. This dichotomy is exemplified by cathepsin L (CTSL), which helps Hendra virus and SARS coronavirus to invade cells, but is essential for survival in mice with mycoplasma pneumonia. The…
Position: 8740 (27 views)
Communicable Diseases Prioritized According to Their Public Health Relevance, Sweden, 2013.
To establish strategic priorities for the Public Health Agency of Sweden we prioritized pathogens according to their public health relevance in Sweden in order to guide resource allocation. We then compared the outcome to ongoing surveillance. We…
Position: 10268 (25 views)
Comprehensive structural analysis of designed incomplete polypeptide chains of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus.
The cotranslational folding is recognized as a very cooperative process that occurs after the nearly completion of the polypeptide sequence of a domain. Here we investigated the challenges faced by polypeptide segments of a non-vectorial β-barrel…
Position: 8052 (28 views)
The impact of matching vaccine strains and post-SARS public health efforts on reducing influenza-associated mortality among the elderly.
Public health administrators do not have effective models to predict excess influenza-associated mortality and monitor viral changes associated with it. This study evaluated the effect of matching/mismatching vaccine strains, type/subtype pattern…
Position: 6866 (30 views)
Characterization of Two Monoclonal Antibodies That Recognize Linker Region and Carboxyl Terminal Domain of Coronavirus Nucleocapsid Protein.
The transmissible gastroenteritis virus (TGEV) nucleocapsid (N) protein plays important roles in the replication and translation of viral RNA. The present study provides the first description of two monoclonal antibodies (mAbs) (5E8 and 3D7) directed…
Position: 5549 (33 views)