2047 10 20655 https://www.socictopen.socict.org/files/original/5de7bc4973a72a97cd115f6fa4abc6d1.pdf 2eb9014c460b18bdf4d1e0c7ce36122b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The impact of digital technology on the quality of higher education Creator An entity primarily responsible for making the resource Zaborova Elena Description An account of the resource COVID-19 pandemic intensified the transition to online learning practices. The article aims to analyse how students perceive distance education quality compared to face-to-face education mode. The author argues that the groups of social actors, interested in the promotion of distance education in higher schools, include: university leadership, geographically and physically disadvantaged students. In the period 2015-2020 the group of USUE researchers conducted a series of students’ surveys. Analysing the survey findings, the author states that despite the benefits of distance education, students consider that the quality of distance learning is inferior to the traditional face-to-face education mode. Among the problems faced by students in distance learning, is their inability to select information, assess its reliability, and differentiate significant information from insignificant. It is concluded that it is of great importance to continue research into the impacts of digitalization on the quality of higher education. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1051/shsconf/20219901044 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Social Sciences https://www.socictopen.socict.org/files/original/b18d01d351ecc5600f8f74e249e3ce19.pdf ec0d016ce088e50184425f873521216d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain. Creator An entity primarily responsible for making the resource Zachariah P. Schuurs, Edward Hammond, Timothy R. Rudd, Yassir A. Ahmed, Deirdre R. Coombe, Stefano Elli, Courtney J Mycroft-West, Marcelo A Lima, Mark A Skidmore, Richard Karlsson, Yen-Hsi Chen, Ieva Bagdonaite, Zhang Yang, Derek J Richard, Jeremy Turnbull, Vito Ferro, Neha S Gandhi Description An account of the resource SARS-CoV-2 has rapidly spread throughout the world's population since its initial discovery in 2019. The virus infects cells via a glycosylated spike protein located on its surface. The protein primarily binds to the angiotensin-converting enzyme-2 (ACE2) receptor, using glycosaminoglycans (GAGs) as co-receptors. Here, we performed bioinformatics and molecular dynamics simulations of the spike protein to investigate the existence of additional GAG binding sites on the receptor-binding domain (RBD), separate from previously reported heparin-binding sites. A putative GAG binding site in the N-terminal domain (NTD) of the protein was identified, encompassing residues 245-246. We hypothesized that GAGs of a sufficient length might bridge the gap between this site and the PRRARS furin cleavage site, including the mutation S247R. Docking studies using GlycoTorch Vina and subsequent MD simulations of the spike trimer in the presence of dodecasaccharides of the GAGs heparin and heparan sulfate supported this possibility. The heparan sulfate chain bridged the gap, binding the furin cleavage site and S247R. In contrast, the heparin chain bound the furin cleavage site and surrounding glycosylation structures, but not S247R. These findings identify a site in the spike protein that favors heparan sulfate binding that may be particularly pertinent for a better understanding of the recent UK and South African strains. This will also assist in future targeted therapy programs that could include repurposing clinical heparan sulfate mimetics. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource coronavirus, spike protein, covid-19, SARS-CoV-2, heparin, heparan sulfate, Cosolvent MD simulations Identifier An unambiguous reference to the resource within a given context 10.1016/j.csbj.2021.05.002 Source A related resource from which the described resource is derived Computational and structural biotechnology journal https://www.socictopen.socict.org/files/original/bb8cea1863c6c7ed3013806e74b90cda.pdf 650c4718757c4d03f6273ea44a3e91b0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Therapeutic Uses of Exosomes Creator An entity primarily responsible for making the resource Zacharias E. Suntres, Milton G. Smith, Fatemeh Momen-Heravi, Jie Hu, Xin Zhang, Ying Wu, Hongguang Zhu, Jiping Wang, Jian Zhou, Winston Patrick Kuo Description An account of the resource Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many cell types into the extracellular milieu. Exosomes are found in cell culture supernatants and in different biological fluids and are known to be secreted by most cell types under normal and pathological conditions. Considerable research is focusing on the exploitation of exosomes in biological fluids for biomarkers in the diagnosis of disease. More recently, exosomes are being exploited for their therapeutic potential. Exosomes derived from dendritic cells, tumor cells, and malignant effusions demonstrate immunomodulatory functions and are able to present antigens to T-cells and stimulate antigen-specific T-cell responses. Exosomes have also been examined for their therapeutic potential in the treatment of infections such as toxoplasmosis, diphtheria, tuberculosis and atypical severe acute respiratory syndrome as well as autoimmune diseases. Attempts to find practical applications for exosomes continue to expand with the role of exosomes as a drug delivery system for the treatment of autoimmune/inflammatory diseases and cancers. Date A point or period of time associated with an event in the lifecycle of the resource 2013 Identifier An unambiguous reference to the resource within a given context DOI: 10.5772/56522 Source A related resource from which the described resource is derived Journal of Circulating Biomarkers Publisher An entity responsible for making the resource available SAGE Publishing Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neoplasms. Tumors. Oncology. Including cancer and carcinogens Language A language of the resource EN https://www.socictopen.socict.org/files/original/32160d75af42e4651cc35b4d2a80bfe1.pdf 0852ddf7f3b702811719a7d3099dd663 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Persuasive power concerning COVID-19 employed by Premier Imran Khan: A socio-political discourse analysis Creator An entity primarily responsible for making the resource Zafar Iqbal, Muhammad Zammad Aslam, Talha Aslam, Rehana Ashraf, Muhammad Kashif, Hafiz Nasir Description An account of the resource The researchers investigate Pakistani Premier Imran Khan’s (IK) addresses to the nation concerning awareness about the causes, effects, precautions, and solutions of the Novel Corona Virus (COVID-19). Till the date, experts are not sure whether the vaccine will get developed or would we have to live with this as we did with HIV or Dengue. Consequently, leaders would need to address their nations, focusing specifically on precautions. The present research employs Aristotle’s persuasive and rhetorical devices, integrating them with Socio-Political Discourse Analysis (SPDA), to understand the social and political convincing style employed by the premiere. The researchers analyzed the data employing a qualitative approach. There are reliable findings to suggest that IK has used stable linguistic features to persuade the minds of the people, convincing them to follow the precautionary measures as ‘the only cure.’ The defending arguments about semi-lockdown or smart-lockdown were well-defined persuading the individuals; for instance, he suggested the smart-lockdown during his first address and faced criticism from the opposition. Later, the opposition and the world appreciated the policy of IK, the Premier of Pakistan, even being a developing country in the sight of the world. After one month of the first patient of the corona case reported in China, the policy of smart-lockdown was followed by most of the states fighting against COVID-19. Moreover, The Premier successfully persuaded the international financial organizations – IMF, World Bank, Development Banks, convincing them to waive off the pending payments of developing countries for the upcoming year. Keywords: COVID19, Persuasion, Socio-Political Discourse Analysis, Speeches, Linguistic Features Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.18326/rgt.v13i1.208-230 Source A related resource from which the described resource is derived Register Journal Publisher An entity responsible for making the resource available IAIN Salatiga Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant English language, Language. Linguistic theory. Comparative grammar https://www.socictopen.socict.org/files/original/6374068d9a7d713e26aefa6a39f4f97f.pdf 500579f72abb68a764d6aad1e5015c40 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Maladaptive Cognitive Bias in the New Normal Period: An Analyses from a Behavioural Science Perspective in the Time of Covid-19 Creator An entity primarily responsible for making the resource Zafira Rahmania Nur Shabrina, Insan Rekso Adiwibowo, Nurul Aisya Beryllia Description An account of the resource The limited number of effective medical interventions to combat Covid-19 to date has resulted in government institutions focusing on preventive behaviours believed to minimize virus transmission. The Indonesian government has launched a ‘new normal’ campaign whereby outdoor activities are restricted by various health protocols established by health authorities, such as wearing a mask, habitual hand washing and social distancing. However, these protocols have not been implemented with a thorough understanding of human behaviour. The result is numerous violations of the protocol, which subsequently lead to the persistence of Covid-19 cases in Indonesia. Behavioural science as an approach can provide important insights regarding the systematic errors of thought that contribute to non-compliance with Covid-19 health signs. This article will elaborate on the different types of systematic errors, known as cognitive biases, that plays a role in Covid-19 protocol compliance and suggest the corresponding solutions deemed most effective to overcome these obstacles. Understanding of the dynamics paired with the application of behaviourally informed strategies will hence contribute to the attempt to flatten the Covid-19 curve. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, New normal, cognitive bias, Protocol Compliance Identifier An unambiguous reference to the resource within a given context 10.22146/buletinpsikologi.60763 Source A related resource from which the described resource is derived Buletin Psikologi Publisher An entity responsible for making the resource available Universitas Gadjah Mada Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Psychology https://www.socictopen.socict.org/files/original/6a8d74433b7756f593450cbfa3cca007.pdf 46681739caed7ca56c2edcefd2134d51 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource On the Coronavirus (COVID-19) Outbreak and the Smart City Network: Universal Data Sharing Standards Coupled with Artificial Intelligence (AI) to Benefit Urban Health Monitoring and Management Creator An entity primarily responsible for making the resource Zaheer Allam, David S. Jones Description An account of the resource As the Coronavirus (COVID-19) expands its impact from China, expanding its catchment into surrounding regions and other countries, increased national and international measures are being taken to contain the outbreak. The placing of entire cities in ‘lockdown’ directly affects urban economies on a multi-lateral level, including from social and economic standpoints. This is being emphasised as the outbreak gains ground in other countries, leading towards a global health emergency, and as global collaboration is sought in numerous quarters. However, while effective protocols in regard to the sharing of health data is emphasised, urban data, on the other hand, specifically relating to urban health and safe city concepts, is still viewed from a nationalist perspective as solely benefiting a nation’s economy and its economic and political influence. This perspective paper, written one month after detection and during the outbreak, surveys the virus outbreak from an urban standpoint and advances how smart city networks should work towards enhancing standardization protocols for increased data sharing in the event of outbreaks or disasters, leading to better global understanding and management of the same. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Urban Health, smart cities, artificial intelligence, coronavirus, Pandemics, future cities, Internet of Things (IoT), COVID-19, 2019ncov Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/healthcare8010046 Source A related resource from which the described resource is derived Healthcare Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/e471d51cf1d9f52e5bb871dd96c67ea9.pdf b13b2c3dd5f34606158372be6f91e369 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Together we unite: the role of the Commonwealth in achieving universal health coverage through pharmaceutical care amidst the COVID-19 pandemic Creator An entity primarily responsible for making the resource Zaheer-ud-din Babar, Diane Ashiru-Oredope, Chloe Tuck, Amy Hai Yan Chan, Victoria Rutter Description An account of the resource Abstract The world currently faces unprecedented health challenges as COVID-19 poses a huge threat to health systems, economies and societies as we know it. The events of the current COVID-19 pandemic have further emphasised existing issues within our health systems. There is no better time than now to come together in global solidarity to tackle these evolving threats of COVID-19 pandemic. The Commonwealth is an ideally placed network to tackle these global health challenges, with its wide-reaching networks of governmental, non-governmental and civil society organisations across all continents. Although the biennial Commonwealth Heads of Government Meeting (CHOGM) originally scheduled to take place in Kigali in Rwanda 22–27 June 2020 has been postponed in view of COVID-19, Commonwealth country discussions are continuing, centred on the CHOGM key theme of ‘Delivering a Common Future: Connecting, Innovating, Transforming’, and five subthemes of Information and Communications Technology (ICT) and Innovation; Trade; Environment; Governance and the Rule of Law; and Youth. The planned CHOGM and Commonwealth itself provides all members a timely platform to consider innovative ways to connect, innovate and transform healthcare to meet the needs of their populations. This commentary considers these five CHOGM subthemes and how member nations can be supported to achieve universal health coverage through optimising medicines use and outcomes, in the midst of a global pandemic in line with the global health agenda. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Health, commonwealth, Pharmacy, Pharmacists, Pandemic, Heads of government Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s40545-020-00214-6 Source A related resource from which the described resource is derived Journal of Pharmaceutical Policy and Practice Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology, Pharmacy and materia medica https://www.socictopen.socict.org/files/original/9e0c229bf872ec80d093cdcfdb3ebcad.pdf 30ca3cd606a83cbf722193f0daa19c8e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Pharmacists at the frontline beating the COVID-19 pandemic Creator An entity primarily responsible for making the resource Zaheer-ud-din Babar, Huma Rasheed, Nadia Bukhari, Bismah Nayyer Description An account of the resource Abstract As the lockdowns are being observed all over the globe and the national level pharmacy professionals are performing frontline roles, this editorial highlights the role of pharmacists in the COVID − 19 pandemic. Pharmacists globally are providing services amidst pandemic, including TRIAGE services, seeing patients and reducing the patients’ burden on health care facilities such as hospitals and GP practices. Pharmacists are also working to providing home deliveries, as well as dealing with the increasing number of patients coming through to pharmacies with the other ailments. Pharmacy associations have issued their guidelines and in this editorial, several global examples of pharmacists’ role in the COVID 19 are being discussed. Pakistan is used as a country case study in this editorial. The editorial also elaborates how pharmacists in the UK and Pakistan have teamed up together to compile 10-steps protection guidelines for the pharmacy teams in Pakistan in English and Urdu language. This 10-point guidance educates community pharmacies for safety and standard operation as the number of patients in the country continues to rise. These guidelines are endorsed by the government and private bodies. These can be adopted and adapted by any country; keeping in view their laws and regulations. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s40545-020-00210-w Source A related resource from which the described resource is derived Journal of Pharmaceutical Policy and Practice Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology, Pharmacy and materia medica https://www.socictopen.socict.org/files/original/3da0deff94f1c9d26778a9bf02faeadc.pdf eda3dff2fa491ba59536218dfdf2dc03 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A step towards gender equity to strengthen the pharmaceutical workforce during COVID-19 Creator An entity primarily responsible for making the resource Zaheer-ud-din Babar, Madeeha Malik, Huma Rasheed, Mehr Manzoor, Nadia Bukhari, Bismah Nayyer Description An account of the resource Abstract There is plenty of evidence to support that women leaders are needed in the health and pharmaceutical sectors, although most of the leadership positions in global health are predominantly occupied by men. This is a major challenge to global health policy. Gender diversity and inclusion within the pharmaceutical workforce is integral to optimal patient care. Women continue to be underrepresented in senior and leadership positions within pharmacy, despite outnumbering the men in the global pharmacy workforce. This commentary highlights the need towards gender equity and discusses the several key initiatives that are building momentum and making substantial progress towards this agenda in the pharmaceutical workforce. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s40545-020-00215-5 Source A related resource from which the described resource is derived Journal of Pharmaceutical Policy and Practice Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology, Pharmacy and materia medica https://www.socictopen.socict.org/files/original/57b3ae4c89de4d161d72b0d53c021558.pdf 443cab55f39c04034f96cc620ce875f8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Renal Manifestations of Covid-19: Physiology and Pathophysiology Creator An entity primarily responsible for making the resource Zaher Armaly, Safa Kinaneh, Karl Skorecki Description An account of the resource Corona virus disease 2019 (COVID-19) imposes a serious public health pandemic affecting the whole world, as it is spreading exponentially. Besides its high infectivity, SARS-CoV-2 causes multiple serious derangements, where the most prominent is severe acute respiratory syndrome as well as multiple organ dysfunction including heart and kidney injury. While the deleterious impact of SARS-CoV-2 on pulmonary and cardiac systems have attracted remarkable attention, the adverse effects of this virus on the renal system is still underestimated. Kidney susceptibility to SARS-CoV-2 infection is determined by the presence of angiotensin-converting enzyme 2 (ACE2) receptor which is used as port of the viral entry into targeted cells, tissue tropism, pathogenicity and subsequent viral replication. The SARS-CoV-2 cellular entry receptor, ACE2, is widely expressed in proximal epithelial cells, vascular endothelial and smooth muscle cells and podocytes, where it supports kidney integrity and function via the enzymatic production of Angiotensin 1-7 (Ang 1-7), which exerts vasodilatory, anti-inflammatory, antifibrotic and diuretic/natriuretic actions via activation of the Mas receptor axis. Loss of this activity constitutes the potential basis for the renal damage that occurs in COVID-19 patients. Indeed, several studies in a small sample of COVID-19 patients revealed relatively high incidence of acute kidney injury (AKI) among them. Although SARS-CoV-1 -induced AKI was attributed to multiorgan failure and cytokine release syndrome, as the virus was not detectable in the renal tissue of infected patients, SARS-CoV-2 antigens were detected in kidney tubules, suggesting that SARS-CoV-2 infects the human kidney directly, and eventually induces AKI characterized with high morbidity and mortality. The mechanisms underlying this phenomenon are largely unknown. However, the fact that ACE2 plays a crucial role against renal injury, the deprivation of the kidney of this advantageous enzyme, along with local viral replication, probably plays a central role. The current review focuses on the critical role of ACE2 in renal physiology, its involvement in the development of kidney injury during SARS-CoV-2 infection, renal manifestations and therapeutic options. The latter includes exogenous administration of Ang (1-7) as an appealing option, given the high incidence of AKI in this ACE2-depleted disorder, and the benefits of ACE2/Ang1-7 including vasodilation, diuresis, natriuresis, attenuation of inflammation, oxidative stress, cell proliferation, apoptosis and coagulation. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource SARS-CoV-2, Kidney, acute kidney injury, covid-19 pandemic, dialysis, angiotensin-converting enzyme 2 Identifier An unambiguous reference to the resource within a given context 10.3390/jcm10061216 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine