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The Coronavirus Nucleocapsid Is a Multifunctional Protein
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and…
Position: 10240 (25 views)
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function
Abstract Background Leveraging previously identified viral interactions with human host proteins, we apply a machine learning-based approach to connect SARS-CoV-2 viral proteins to relevant host biological functions, diseases, and pathways in a…
Position: 16091 (19 views)
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.
ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known as PARPs. While several PARPs…
Position: 11154 (24 views)
The Coronavirus E Protein: Assembly and Beyond
The coronavirus E protein is a small membrane protein that has an important role in the assembly of virions. Recent studies have indicated that the E protein has functions during infection beyond assembly, including in virus egress and in the host…
Position: 8718 (27 views)
The coronavirus as test of resistance to European integration: limits of constitutional dialogue
This article aims to provide an analysis of the European Union's response to the coronavirus crisis, particularly in relation to multilevel relations with Member States. The mainly financial response to the crisis and the political and legal readings…
Position: 16091 (19 views)
The coronavirus and plastics
editorial
Position: 9448 (26 views)
The Corona Virus (COVID-19) Pandemic and the Challenge of Healthcare Infrastructure in Nigeria: What Role for Public-private Partnerships?
While it is not new that Nigeria is challenged by a huge infrastructure deficit, the COVID-19 pandemic has exposed the country’s comatose healthcare system. Given the country’s dwindling revenue, massive debt profile and the inability of the…
Position: 4295 (37 views)
THE COOPERATIVE WORK AND FAMILY FARMING ECOLOGICALLY BASED: ACTIONS FOR SUSTAINABLE DEVELOPMENT FROM THE LOCAL REALITY
This study aimed to characterize the associated farmers to Cooperativa Sul Ecológica de Agricultores Familiares Ltda., and to understand the organization of the cooperative institution. For this, we conducted semi-structured interviews with the…
Position: 8718 (27 views)
The Controversy on the Role of ACE2 Receptor in COVID-19 Infection: The Protective Shift toward the ACE2 Axis
Background: Angiotensin-converting enzyme 2 (ACE2) is recognized as the main cellular receptor for the new coronavirus, SARS-CoV-2, that facilitates its entry into the host target cell, leading to the fatal viral infection, coronavirus disease 2019…
Position: 17844 (17 views)
THE CONTRIBUTION OF THE FAMILY FARM FOR RURAL DEVELOPMENT IN MATO GROSSO DO SUL STATE - BRAZIL
This article aims to analyze the contribution of family farming for rural development in the state of Mato Grosso do Sul. The methodology used was based on data from the 2006 Agricultural Census, conducted by the Brazilian Institute of Geography and…
Position: 8718 (27 views)