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                <text>Ground Moving Target Imaging and Analysis for Near-Space Hypersonic Vehicle-Borne Synthetic Aperture Radar System with Squint Angle</text>
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                <text>Zhanye Chen, Yu Zhou, Linrang Zhang, Chun-Hui Lin, Yan Huang, Shiyang Tang</text>
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                <text>Near space is the key to integrating &amp;#8220;sky&amp;#8222; and &amp;#8220;space&amp;#8222; into the future. A synthetic aperture radar (SAR) that works in this area would initiate a technological revolution for remote sensing applications. This study mainly focused on ground moving target imaging (GMTIm) for a near-space hypersonic vehicle-borne SAR (NS-HSV-SAR) with squint angle. The range history, parameter coupling, and Doppler ambiguity of the squint-looking NS-HSV-SAR are more complicated than traditional side-looking airborne or space-borne SARs. Thus, a precise range model is presented on the basis of phase error analyses. Then, all potential distributions of echo&amp;#8217;s azimuth spectrum are derived, and a GMTIm method is proposed on the basis of a detailed analysis of the echo characteristics. The proposed method consists of three steps. Firstly, a prior information-based pre-processing function was created to decrease the Doppler ambiguity and range migration effects. Secondly, a blur matched keystone transform was developed to correct the residual range walk migration. Thirdly, a time-saving chirp Fourier transform was investigated for azimuth focusing. Implementation considerations, including the curvilinear trajectory of the NS-HSV-SAR, multiple moving target imaging, and applicability and limitation of the method, are discussed. Finally, simulation results are presented to validate the effectiveness of the proposed method.</text>
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                <text>near-space hypersonic vehicle, synthetic aperture radar, ground moving target imaging, squint angle, Doppler centre blur, Doppler spectrum ambiguity, curvilinear trajectory</text>
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                <text>DOI: 10.3390/rs10121966</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Spatial Cell Disparity in the Colonial Choanoflagellate Salpingoeca rosetta</text>
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                <text>Benjamin Naumann, Pawel Burkhardt</text>
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                <text>Choanoflagellates are the closest unicellular relatives of animals (Metazoa). These tiny protists display complex life histories that include sessile as well as different pelagic stages. Some choanoflagellates have the ability to form colonies as well. Up until recently, these colonies have been described to consist of mostly identical cells showing no spatial cell differentiation, which supported the traditional view that spatial cell differentiation, leading to the co-existence of specific cell types in animals, evolved after the split of the last common ancestor of the Choanoflagellata and Metazoa. The recent discovery of single cells in colonies of the choanoflagellate Salpingoeca rosetta that exhibit unique cell morphologies challenges this traditional view. We have now reanalyzed TEM serial sections, aiming to determine the degree of similarity of S. rosetta cells within a rosette colony. We investigated cell morphologies and nuclear, mitochondrial, and food vacuole volumes of 40 individual cells from four different S. rosetta rosette colonies and compared our findings to sponge choanocytes. Our analysis shows that cells in a choanoflagellate colony differ from each other in respect to cell morphology and content ratios of nuclei, mitochondria, and food vacuoles. Furthermore, cell disparity within S. rosetta colonies is slightly higher compared to cell disparity within sponge choanocytes. Moreover, we discovered the presence of plasma membrane contacts between colonial cells in addition to already described intercellular bridges and filo-/pseudopodial contacts. Our findings indicate that the last common ancestor of Choanoflagellata and Metazoa might have possessed plasma membrane contacts and spatial cell disparity during colonial life history stages.</text>
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                <text>DOI: 10.3389/fcell.2019.00231</text>
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                <text>Frontiers in Cell and Developmental Biology</text>
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                <text>Frontiers Media S.A.</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV</text>
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                <text>Jiabao Xu, Shizhe Zhao, Tieshan Teng, Abualgasim  Elgaili Abdalla, Wan Zhu, Longxiang Xie, Yunlong Wang, Xiangqian Guo</text>
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                <text>After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumonia patients in the Wuhan seafood market caused a major disease outbreak and has been named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes acute lung symptoms, leading to a condition that has been named as &amp;#8220;coronavirus disease 2019&amp;#8221; (COVID-19). The emergence of SARS-CoV-2 and of SARS-CoV caused widespread fear and concern and has threatened global health security. There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms.</text>
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                <text>coronaviruses, SARS-CoV-2, SARS-CoV, genomic comparison, proteomic comparison, pathogenic mechanism, clinical manifestations</text>
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                <text>DOI: 10.3390/v12020244</text>
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                <text>Bayesian inference of transmission chains using timing of symptoms, pathogen genomes and contact data.</text>
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                <text>Finlay Campbell, Anne Cori, Neil Ferguson, Thibaut Jombart</text>
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                <text>There exists significant interest in developing statistical and computational tools for inferring 'who infected whom' in an infectious disease outbreak from densely sampled case data, with most recent studies focusing on the analysis of whole genome sequence data. However, genomic data can be poorly informative of transmission events if mutations accumulate too slowly to resolve individual transmission pairs or if there exist multiple pathogens lineages within-host, and there has been little focus on incorporating other types of outbreak data. We present here a methodology that uses contact data for the inference of transmission trees in a statistically rigorous manner, alongside genomic data and temporal data. Contact data is frequently collected in outbreaks of pathogens spread by close contact, including Ebola virus (EBOV), severe acute respiratory syndrome coronavirus (SARS-CoV) and Mycobacterium tuberculosis (TB), and routinely used to reconstruct transmission chains. As an improvement over previous, ad-hoc approaches, we developed a probabilistic model that relates a set of contact data to an underlying transmission tree and integrated this in the outbreaker2 inference framework. By analyzing simulated outbreaks under various contact tracing scenarios, we demonstrate that contact data significantly improves our ability to reconstruct transmission trees, even under realistic limitations on the coverage of the contact tracing effort and the amount of non-infectious mixing between cases. Indeed, contact data is equally or more informative than fully sampled whole genome sequence data in certain scenarios. We then use our method to analyze the early stages of the 2003 SARS outbreak in Singapore and describe the range of transmission scenarios consistent with contact data and genetic sequence in a probabilistic manner for the first time. This simple yet flexible model can easily be incorporated into existing tools for outbreak reconstruction and should permit a better integration of genomic and epidemiological data for inferring transmission chains.</text>
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                <text>DOI: 10.1371/journal.pcbi.1006930</text>
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                <text>PLoS Computational Biology</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>An Integrated Approach to Characterize Intestinal Metabolites of Four Phenylethanoid Glycosides and Intestinal Microbe-Mediated Antioxidant Activity Evaluation In Vitro Using UHPLC-Q-Exactive High-Resolution Mass Spectrometry and a 1,1-Diphenyl-2-picrylhydrazyl-Based Assay</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Xiaoming Wang, Xiao-yan CHANG, Xiao-mei Luo, Mei-feng Su, Rong Xu, Jun Chen, Yi Ding, Yu eShi</text>
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            <description>An account of the resource</description>
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              <elementText elementTextId="20206">
                <text>Intestinal bacteria have a significant role in metabolism and the pharmacologic actions of traditional Chinese medicine active ingredients. Phenylethanoid glycosides (PhGs), as typical phenolic natural products, possess wide bioactivities, but low oral bioavailability. The aim of this work was to elucidate the metabolic mechanism underlying PhGs in the intestinal tract and screen for more active metabolites. In this study, a rapid and reliable method using an effective post-acquisition approach based on advanced ultra-high-performance liquid chromatography (UHPLC) coupled with hybrid Quadrupole-Orbitrap high resolution mass spectrometry (Q-Exactive-HRMS) provided full MS and HCD MS2 data. Thermo Scientific™ Compound Discoverer™ software with a Fragment Ion Search (FISh) function in one single workflow was developed to investigate the intestinal microbial metabolism of four typical PhGs. Furthermore, antioxidant activity evaluation of PhGs and their related metabolites was simultaneously carried out in combination with a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay to understand how intestinal microbiota transformations modulate biological activity and explore structure–activity relationships (SARs). As a result, 26 metabolites of poliumoside, 42 metabolites of echinacoside, 42 metabolites of tubuloside, and 46 metabolites of 2′-acetylacteoside were identified. Degradation, reduction, hydroxylation, acetylation, hydration, methylation, and sulfate conjugation were the major metabolic pathways of PhGs. Furthermore, the degraded metabolites with better bioavailability had potent antioxidant activity that could be attributed to the phenolic hydroxyl groups. These findings may enhance our understanding of the metabolism, pharmacologic actions, and real active forms of PhGs.</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="20208">
                <text>intestinal microbial metabolism, four phenylethanoid glycosides, UHPLC-Q-Exactive Orbitrap HRMS, antioxidant activities, structure–activity relationship</text>
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              <elementText elementTextId="20209">
                <text>DOI: 10.3389/fphar.2019.00826</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="20210">
                <text>Frontiers in Pharmacology</text>
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            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="20211">
                <text>Frontiers Media S.A.</text>
              </elementText>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="20212">
                <text>Therapeutics. Pharmacology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20213">
                <text>EN</text>
              </elementText>
            </elementTextContainer>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20214">
                <text>Perception, écriture et domination de l'espace maritime à travers des récits de missionnaires jésuites au XVIIe siècle</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20215">
                <text>Delphine Tempère</text>
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            </elementTextContainer>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="20216">
                <text>Les océans ont longtemps représenté des espaces de frontière. À partir du XVIe siècle cependant, ils deviennent des vecteurs de communication et permettent de relier toutes les parties du monde entre elles et notamment Rome, alors considérée comme le centre de la Chrétienté, aux nouvelles terres à évangéliser. Dans cette étude, l’espace maritime en tant que concept et réalité est interrogé afin de voir, dans un deuxième temps, quelles sont les caractéristiques de l’écriture des missionnaires jésuites sur les océans. Lutte contre les forces maléfiques, purification et conversion des hommes d’équipage et des espaces maritimes, intercessions prodigieuses et miracles sur les mers tourmentées vont alors apparaître comme les ressorts de l’écriture jésuite afin d’imposer l’Ordre sur les océans. Ces espaces irréductibles deviennent alors, selon, et sous la plume des missionnaires, le lieu de l’œuvre divine jalonné par leurs intercessions prodigieuses dans un immense réseau planétaire maritime qu’ils parcourent et sacralisent par leurs écrits.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20217">
                <text>2013</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="20218">
                <text>espace maritime, Domination, Conversion, Écriture, Jésuites</text>
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            </elementTextContainer>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="20219">
                <text>DOI: 10.4000/e-spania.21972</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="20220">
                <text>E-Spania</text>
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            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="20221">
                <text>Civilisations et Littératures d’Espagne et d’Amérique du Moyen Âge aux Lumières (CLEA) - Paris Sorbonne</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="20222">
                <text>History (General) and history of Europe, History of Spain</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20223">
                <text>ES, FR, LA, PT</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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  <item itemId="2105" public="1" featured="0">
    <fileContainer>
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              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="20224">
                <text>Claude Martinaud, Frank Paris, Océans, mers et îles - Appuis de la mondialisation</text>
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            </elementTextContainer>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20225">
                <text>Yves Boquet</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="20226">
                <text>2015</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="20227">
                <text>DOI: </text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="20228">
                <text>Territoire en Mouvement</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="20229">
                <text>Université Lille 1</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="20230">
                <text>Geography (General)</text>
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            </elementTextContainer>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20231">
                <text>EN, FR</text>
              </elementText>
            </elementTextContainer>
          </element>
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          <name>Dublin Core</name>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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              <elementText elementTextId="20232">
                <text>Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19)</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="20233">
                <text>Asami Anzai, Tetsuro Kobayashi, Natalie  M. Linton, Ryo Kinoshita, Katsuma Hayashi, Ayako Suzuki, Yichi Yang, Sung-Mok Jung, Takeshi Miyama, Andrei R. Akhmetzhanov, Hiroshi Nishiura</text>
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            <description>An account of the resource</description>
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                <text>The impact of the drastic reduction in travel volume within mainland China in January and February 2020 was quantified with respect to reports of novel coronavirus (COVID-19) infections outside China. Data on confirmed cases diagnosed outside China were analyzed using statistical models to estimate the impact of travel reduction on three epidemiological outcome measures: (i) the number of exported cases, (ii) the probability of a major epidemic, and (iii) the time delay to a major epidemic. From 28 January to 7 February 2020, we estimated that 226 exported cases (95% confidence interval: 86,449) were prevented, corresponding to a 70.4% reduction in incidence compared to the counterfactual scenario. The reduced probability of a major epidemic ranged from 7% to 20% in Japan, which resulted in a median time delay to a major epidemic of two days. Depending on the scenario, the estimated delay may be less than one day. As the delay is small, the decision to control travel volume through restrictions on freedom of movement should be balanced between the resulting estimated epidemiological impact and predicted economic fallout.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>migration, quarantine, travel, imported case, emerging infectious diseases</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="20237">
                <text>DOI: 10.3390/jcm9020601</text>
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              <elementText elementTextId="20238">
                <text>Journal of Clinical Medicine</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="20239">
                <text>MDPI AG</text>
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            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20241">
                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
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                <text>Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review</text>
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                <text>Junxiong Pang, Minxian Wang, Ian Yi Han Ang, Sharon Hui Xuan Tan, Ruth Frances Lewis, Jacinta I-Pei Chen, Ramona A. Gutiérrez, Sylvia Xiao Wei Gwee, Pearleen Ee Yong Chua, Qian Yang, Xian Ying, Rowena KS Yap, Hao Yi Tan, Yik-Ying Teo, Chorh Chuan Tan, Alex R Cook, Jason Chin-Huat Yap, Li Yang Hsu</text>
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            <description>An account of the resource</description>
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                <text>Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. It is timely to systematically review the potential of these interventions, including those for Middle East respiratory syndrome-Coronavirus (MERS-CoV) and severe acute respiratory syndrome (SARS)-CoV, to guide policymakers globally on their prioritization of resources for research and development. A systematic search was carried out in three major electronic databases (PubMed, Embase and Cochrane Library) to identify published studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Supplementary strategies through Google Search and personal communications were used. A total of 27 studies fulfilled the criteria for review. Several laboratory protocols for confirmation of suspected 2019-nCoV cases using real-time reverse transcription polymerase chain reaction (RT-PCR) have been published. A commercial RT-PCR kit developed by the Beijing Genomic Institute is currently widely used in China and likely in Asia. However, serological assays as well as point-of-care testing kits have not been developed but are likely in the near future. Several vaccine candidates are in the pipeline. The likely earliest Phase 1 vaccine trial is a synthetic DNA-based candidate. A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. Some are being tested in clinical trials against MERS-CoV and SARS-CoV, while others have been listed for clinical trials against 2019-nCoV. However, there are currently no effective specific antivirals or drug combinations supported by high-level evidence.</text>
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            <name>Date</name>
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              <elementText elementTextId="20245">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20246">
                <text>novel coronavirus, diagnostics, vaccine, treatments, global health, Outbreak, MERS-CoV, SARS-CoV</text>
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            <name>Identifier</name>
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              <elementText elementTextId="20247">
                <text>DOI: 10.3390/jcm9030623</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="20248">
                <text>Journal of Clinical Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="20249">
                <text>MDPI AG</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                <text>EN</text>
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        <src>https://www.socictopen.socict.org/files/original/6837d973fba3bbfe28cae86bdcb9b00e.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
            <name>Title</name>
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                <text>A cluster-randomised controlled trial to test the efficacy of facemasks in preventing respiratory viral infection among Hajj pilgrims</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20253">
                <text>Mandy Wang, Osamah Barasheed, Harunor Rashid, Robert Booy, Haitham El-Bashir, Elizabeth Haworth, Iman Ridda, Edward C. Holmes, Dominic E. Dwyer, Jonathan Nguyen-Van-Tam, Ziad A Memish, Leon Heron</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="20254">
                <text>Background: Cost-effective interventions are needed to control the transmission of viral respiratory tract infections (RTIs) in mass gatherings. Facemasks are a promising preventive measure, however, previous studies on the efficacy of facemasks have been inconclusive. This study proposes a large-scale facemask trial during the Hajj pilgrimage in Saudi Arabia and presents this protocol to illustrate its feasibility and to promote both collaboration with other research groups and additional relevant studies.Methods/design: A cluster-randomised controlled trial is being conducted to test the efficacy of standard facemasks in preventing symptomatic and proven viral RTIs among pilgrims during the Hajj season in Mina, Mecca, Saudi Arabia. The trial will compare the ‘supervised use of facemasks’ versus ‘standard measures’ among pilgrims over several Hajj seasons. Cluster-randomisation will be done by accommodation tents with a 1:1 ratio. For the intervention tents, free facemasks will be provided to be worn consistently for 7 days. Data on flu-like symptoms and mask use will be recorded in diaries. Nasal samples will be collected from symptomatic recruits and tested for nucleic acid of respiratory viruses. Data obtained from questionnaires, diaries and laboratory tests will be analysed to examine whether mask use significantly reduces the frequency of laboratory-confirmed respiratory viral infection and syndromic RTI as primary outcomes.Conclusions: This trial will provide valuable evidence on the efficacy of standard facemask use in preventing viral respiratory tract infections at mass gatherings.This study is registered at the Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN: ACTRN12613001018707 (http://www.anzctr.org.au).</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="20255">
                <text>2019</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="20256">
                <text>facemask, Hajj pilgrimage, influenza, Middle East respiratory syndrome coronavirus, Viral respiratory tract infection</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="20257">
                <text>DOI: 10.1016/j.jegh.2014.08.002</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="20258">
                <text>Journal of Epidemiology and Global Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="20259">
                <text>Atlantis Press</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="20260">
                <text>Public aspects of medicine</text>
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            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20261">
                <text>EN</text>
              </elementText>
            </elementTextContainer>
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