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Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach
Arafat Rahman Oany,1 Abdullah-Al Emran,1,2 Tahmina Pervin Jyoti3 1Department of Biotechnology and Genetic Engineering, Life Science Faculty, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh; 2Translational Research Institute,…
Position: 12071 (23 views)
Cross-sectional survey of selected enteric viruses in Polish turkey flocks between 2008 and 2011
Abstract Background Enteric diseases are an important health problem for the intensive poultry industry, resulting in considerable economic losses. Apart from such microbiological agents associated with enteritis as bacteria and parasites, a lot of…
Position: 17837 (17 views)
Identification of a mutation in the spike protein cleavage site in Brazilian strains of wild-type bovine coronavirus Identificação de uma mutação no sítio de clivagem da proteína da espícula em amostras brasileiras de coronavírus bovino
The spike (S) protein of coronaviruses, a type I membrane glycoprotein, is primarily responsible for entry into susceptible cells by binding with specific receptors on cells and mediating subsequent virus-cell fusion. The bovine coronavirus (BCoV) S…
Position: 17837 (17 views)
Síndrome respiratorio agudo severo (SRAS)
In this review we present the main historical, epidemiological, clinical and control& prevention aspects of this new disease known as Severe Acute Respiratory Syndrome (SARS). This has been considered the first epidemic infectious disease of the XXI…
Position: 152 (107 views)
Origin, diversity and maturation of human antiviral antibodies analyzed by high-throughput sequencing
Our understanding of how antibodies are generated and function could help develop effective vaccines and antibody-based therapeutics against viruses such as HIV-1, SARS Coronavirus (CoV), and Hendra and Nipah viruses (henipaviruses). Although broadly…
Position: 14067 (21 views)
Elements of successful management of an imported Middle East respiratory syndrome case in Guangdong, China
Position: 14067 (21 views)
Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus
Abstract Background Antigenic diversity in dengue virus strains has been studied, but large-scale and detailed systematic analyses have not been reported. In this study, we report a bioinformatics method for analyzing viral antigenic diversity in the…
Position: 14067 (21 views)
Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein <it>in-vitro </it>and <it>in-vivo</it>
Abstract During the outbreak of SARS in 2002/3, a prototype virus was isolated from a patient in Frankfurt/Germany (strain Frankfurt-1). As opposed to all other SARS-Coronavirus strains, Frankfurt-1 has a 45-nucleotide deletion in the transmembrane…
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First record of Daphnia lumholtzi (Sars, 1885), exotic cladoceran, in São Paulo State (Brazil)
Position: 6824 (30 views)
Bats and Coronaviruses
Bats are speculated to be reservoirs of several emerging viruses including coronaviruses (CoVs) that cause serious disease in humans and agricultural animals. These include CoVs that cause severe acute respiratory syndrome (SARS), Middle East…
Position: 13036 (22 views)