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Pilgerodendron uviferum (D. Don) Florin is an endemic, threatened conifer that grows in South America. In the sub-Antarctic territory, one of the most isolated places in the world, some forest patches remain untouched since the last glaciation. In…

Myeloid cell leukemia 1 (Mcl-1) and B-cell lymphoma 2 (Bcl-2) proteins are promising targets for cancer therapy. Here, we investigated the structure–activity relationships (SARs) and performed molecular docking analysis of renieramycin T (RT) and its…

For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments. Recently, numerous reports highlighted the crucial role of the…

With the emergence and global spread of the COVID-19 pandemic, the scientific community worldwide has focused on search for new therapeutic strategies against this disease. One such critical approach is targeting proteins such as helicases that…

Bacterial resistance towards the existing class of antibacterial drugs continues to increase, posing a significant threat to the clinical usefulness of these drugs. These increasing and alarming rates of antibacterial resistance development and the…

FMRF-NH2 peptides which contain a conserved, identical C-terminal tetrapeptide but unique N terminus modulate cardiac contractility; yet, little is known about the mechanisms involved in signaling. Here, the structure-activity relationships (SARs) of…

Cassia obtusifolia Linn. have been used to improve vision, inflammatory diseases, and as hepatoprotective agents and to promote urination from ancient times. In the present study, we investigated the influence of glycosylation of components of C.…

Tropical montane forests have the highest biodiversity in the world. However, they are being seriously threatened by deforestation, degradation and climate change. Their conservation is also at risk because we know little about their ecology. We…

The objectives of this work were to evaluate the richness and diversity of the Poduromorpha fauna in two biotopes in Restinga de Maricá, RJ, Brazil, to identify the characteristic species of each biotope and to determine the relationships between the…

Coronaviruses recognize a variety of receptors using different domains of their envelope-anchored spike protein. How these diverse receptor recognition patterns affect viral entry is unknown. Mouse hepatitis coronavirus (MHV) is the only known…