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Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging.
The nucleocapsid (N) phosphoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV) packages the viral genome into a helical ribonucleocapsid and plays a fundamental role during viral self-assembly. The N protein consists of two…
Position: 6830 (30 views)
Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging.
The nucleocapsid (N) phosphoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV) packages the viral genome into a helical ribonucleocapsid and plays a fundamental role during viral self-assembly. The N protein consists of two…
Position: 16091 (19 views)
Targeting protein-protein interaction interfaces in COVID-19 drug discovery.
To date, the COVID-19 pandemic has claimed over 1 million human lives, infected another 50 million individuals and wreaked havoc on the global economy. The crisis has spurred the ongoing development of drugs targeting its etiological agent, the…
Position: 13046 (22 views)
Viral Load Distribution in SARS Outbreak
An unprecedented community outbreak of severe acute respiratory syndrome (SARS) occurred in the Amoy Gardens, a high-rise residential complex in Hong Kong. Droplet, air, contaminated fomites, and rodent pests have been proposed to be mechanisms for…
Position: 5513 (33 views)
Social reaction toward the 2019 novel coronavirus (COVID-19)
Position: 11151 (24 views)
Motivation to Have COVID-19 Vaccination Explained Using an Extended Protection Motivation Theory among University Students in China: The Role of Information Sources
Background: The aims of the present study were to examine the prediction of the threat and coping appraisal utilizing an extended protection motivation theory (PMT) for the motivation to have COVID-19 vaccination and the influence of various…
Position: 20121 (13 views)
Influence of the COVID-19 pandemic on Asian scholarly journal editors’ daily life, work, and opinions on future journal development
Purpose: This study examined changes in Asian journal editors’ daily life and work during the coronavirus disease 2019 (COVID-19) pandemic and investigated their opinions on expected changes, thereby providing preliminary data to support the future…
Position: 17843 (17 views)
Effectiveness of Arbidol for COVID-19 Prevention in Health Professionals
Background: Frontline health professionals are a COVID-19-susceptible population during the outbreak of COVID-19, but prophylactic drugs against SARS-CoV-2 infection are to be explored.Method: Frontline health professionals diagnosed with COVID-19…
Position: 13046 (22 views)
Design, Synthesis, Activity and Docking Study of Sorafenib Analogs Bearing Sulfonylurea Unit
Two series of novel sorafenib analogs containing a sulfonylurea unit were synthesized and their chemical structures were confirmed by 1H-NMR, 13C-NMR, MS spectrum and elemental analysis. The synthesized compounds were evaluated for the cytotoxicity…
Position: 15148 (20 views)
Insignificant Impact of the “Stay-At-Home” Order on Ambient Air Quality in the Memphis Metropolitan Area, U.S.A.
The lockdowns due to the COVID-19 pandemic have been reported to reduce ambient air pollution in many cities globally. This study aims to examine whether air pollution dropped in Memphis, a typical U.S. metropolitan city and transportation hub,…
Position: 6327 (31 views)