365 10 20655 https://www.socictopen.socict.org/files/original/da0a7eef4d1a3941af71e999dd6c5d24.pdf 738ff6f88ca622465b2cb35c6b92c5c1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Recommendation about the perioperative prevention of infection to healthcare workers and the anesthesia management of children with SARS-CoV-2 infection Creator An entity primarily responsible for making the resource Jinjin Huang, Qiang Shu, Zhiyong Hu, Hongfei Lin, Wenfang Huang, Dongpi Wang, Yaoqin Hu, Ziying Jin, Jiangmei Wang, Jing-zhen Wu, Zhirui Zhu, Miaofeng Hu, Weiqing Shen, Yilei Jiang, Yaojun Suo Description An account of the resource Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread widely and persistently over 100 countries. New challenges have occurred in the perioperative management of airway and anesthesia in children diagnosed with SARS-CoV-2 infection. According to current publications and to our own experiences in anesthesia management for cases with SARS-CoV-2 suspected, we reviewed concerns about the perioperative prevention of SARS-CoV-2 to medical staff and the anesthesia strategy to the patient. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1136/wjps-2020-000126 Source A related resource from which the described resource is derived World Journal of Pediatric Surgery Publisher An entity responsible for making the resource available BMJ Publishing Group Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Surgery, Pediatrics https://www.socictopen.socict.org/files/original/1f5f0a5102627755df46c4767f04e141.pdf e72e8d2fd84030dd131f599b12db847f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Comparisons of Staphylococcus aureus infection and other outcomes between users of angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers: lessons for COVID-19 from a nationwide cohort study [version 1; peer review: 2 approved] Creator An entity primarily responsible for making the resource Liam Smeeth, Laurie A Tomlinson, Masao Iwagami, Ian J Douglas, Charlotte Summers, Fotini Kalogirou, Patrick Bidulka, Kathryn E. Mansfield, Angel Y. S. Wong Description An account of the resource Background: Mice receiving angiotensin converting enzyme inhibitor (ACEI) drugs show increased susceptibility to infection by Staphylococcus aureus (S. aureus). We sought to investigate whether humans using ACEI were at increased risk of S. aureus infection, comparing them to users of Angiotensin II Receptor Blockers (ARB) with multiple control outcomes to assess the potential for residual confounding. Methods: Using the UK Clinical Practice Research Datalink linked to Hospital Episode Statistics between 1997 and 2017, we identified adults starting ACEI or ARB (as an active comparator drug). We regarded prescription of ACEI or ARB as time-dependent exposure and used a Cox regression model to compare incidence of first hospitalisation with infection due to S. aureus in periods with ACEI to periods with ARB prescriptions. We repeated the analysis using control outcomes that we did not expect to be associated with use of ACEI versus ARB (Gram-negative sepsis, hip fracture and herpes zoster) and one that we did (dry cough). Results: We identified 445,341 new users of ACEI (mean age 64.0±14.0, male 51.7%) and 41,824 new users of ARB (mean age 64.1±14.0, male 45.5%). The fully adjusted hazard ratio for S. aureus infection (ACEI vs. ARB) was 1.18 (95% CI 1.10–1.27), consistent across sensitivity analyses. However, we also found associations with all control outcomes; rates of Gram-negative sepsis, hip fracture and dry cough were also increased during periods of time treated with ACEI compared to ARB while herpes zoster was more common during time treated with ARB. Conclusions: Our results suggest that although ARB users appear an ideal control for analyses of ACEI effects, there is residual confounding even after multivariable adjustment. This has implications for observational analyses comparing users of these drug classes, in particular the effect of these drugs in relation to COVID-19 infection. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.12688/wellcomeopenres.15873.1 Source A related resource from which the described resource is derived Wellcome Open Research Publisher An entity responsible for making the resource available Wellcome Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine https://www.socictopen.socict.org/files/original/2b162469df7574f57c99cb56b8c48639.pdf 59c317477bd78a76fdc93ffa616b68e8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Use of Microbial Accessible and Fermentable Carbohydrates and/or Butyrate as Supportive Treatment for Patients With Coronavirus SARS-CoV-2 Infection Creator An entity primarily responsible for making the resource Douglas L. Archer, Dean C. Kramer Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource anti-inflammatory, butyrate, SCFAs, Cytokine storm, Adjunct therapy Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmed.2020.00292 Source A related resource from which the described resource is derived Frontiers in Medicine Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) https://www.socictopen.socict.org/files/original/7478e0022770d8be10a60eec727fdbd6.pdf 99c5789fdd0eda9a3fbb4a091ace6631 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Neurosurgeon Under the Shadow of COVID-19! Creator An entity primarily responsible for making the resource Abrar Ahad Wani, Mohsin Fayaz Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1055/s-0040-1712786 Source A related resource from which the described resource is derived Indian Journal of Neurosurgery Publisher An entity responsible for making the resource available Thieme Medical and Scientific Publishers Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Surgery, Neurology. Diseases of the nervous system https://www.socictopen.socict.org/files/original/f6522fb65bd6c14db82b4fb9cb371a54.pdf 4faef1308c581d8138bfeb51a185511d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Corona virus disease 2019 pandemic: Necessity for active engagement of the private sector Creator An entity primarily responsible for making the resource Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava Description An account of the resource The ongoing Corona Virus Disease-2019 (COVID-19) pandemic has gone beyond the capacity and capability of the public health sector and will essentially require significant support from various sectors for eventually coming out victorious against this novel viral infection. Here arises the role of private health sector, which needs to work in collaboration with the national Governments to bridge the existing lacunae and help the community and the nation at large. As the disease has already affected directly or indirectly millions of human lives across the world, the involvement of the private sector can significantly enhance the range of innovations, production and delivery of the required essentials in these times of public health emergency. In conclusion, the private sector has a crucial role to enhance the resilience of the health system and the time has come when they should work hand-in-hand with the government authorities to maximize the availability of the desired logistics and come out with innovative ways to fight the global battle against COVID-19 pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource private sector, World Health Organization, COVID-19 pandemic Identifier An unambiguous reference to the resource within a given context DOI: 10.4103/dmr.dmr_6_20 Source A related resource from which the described resource is derived Dentistry and Medical Research Publisher An entity responsible for making the resource available Wolters Kluwer Medknow Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Dentistry https://www.socictopen.socict.org/files/original/93b4de2dd889d905bac09cb5a9ba24f4.pdf b302c259afddaf884456596f3eb3a8d1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource An online cross-sectional survey on knowledge, attitudes, practices and perspectives of homoeopathic practitioners towards COVID-19 Creator An entity primarily responsible for making the resource Anil Khurana, Divya Taneja Description An account of the resource Background: In the light of pandemic of coronavirus disease (COVID-19), identification of level of epidemic preparedness and understanding of homoeopathic practitioners is required to utilise their services in mainstream healthcare effectively. Objective: The objective of this study was to identify knowledge, attitudes and practices of homoeopathic physicians about COVID-19. Methodology: An online cross-sectional survey was undertaken in the midst of the epidemic in India when services of homoeopathic doctors were under consideration. The ten knowledge questions were scored and analysed to identify differences with sociodemographic variables. Responses to the ten questions on attitudes and practices were analysed to identify differences in the domains, differing significantly in knowledge scores. Results: Out of 3901 responses received over 2 days, 3595 were included for analysis. Knowledge scores significantly differed with qualification (graduates – 8.60 ± 1.38, post-graduates – 8.84 ± 1.29 and other qualifications – 8.56 ± 1.31) and years of practice (10 years – 8.84 ± 1.30). Gender was not identified as a variable to affect knowledge scores significantly. Attitudes and practices were also identified to be more favourable in participants with more than 10 years' experience. Conclusion: Homoeopathic physicians have largely been able to maintain a high level of currency of knowledge, purely on their own accord. Specific aspects related to patient care and practices need to be further enhanced. Practitioners affirmed that homoeopathic medicines need to be validated on a group of patients before mass treatment/prevention can be identified for which immediate access to patients is required. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Practice, Attitude, Knowledge, COVID-19, homoeopathic physicians Identifier An unambiguous reference to the resource within a given context DOI: 10.4103/ijrh.ijrh_35_20 Source A related resource from which the described resource is derived Indian Journal of Research in Homoeopathy Publisher An entity responsible for making the resource available Wolters Kluwer Medknow Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Homeopathy https://www.socictopen.socict.org/files/original/7773013446e8127de6fc622f004898b1.pdf 4bd122267004db24b6b33fb61ec5d1a1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Lifestyles and living standard disparities in the pandemicity of COVID-19 in the Global North <em>versus</em> the Global South Countries Creator An entity primarily responsible for making the resource Takele Taye Desta Description An account of the resource The coronavirus disease-19 (COVID-19) pandemic is imposing an extraordinary threat to global health. Consequently, fear has been raised in that the COVID-19 pandemic could disproportionately affect lowincome countries. Low-income countries are mainly concentrated in the Global South of the tropics with a high diversity of pathogens, and a considerable proportion of people living under chronic poverty. All these risks might have made Southern people develop a sort of herd immunity and resilience against a broad range of infections. The analysis of the COVID-19 Worldometers data by using country-, territory-, or conveyance-wise summarized in Global North (64 countries) and Global South (147 countries) suggested the high incidence of COVID-19 infection in the North world countries. However, this should be treated with caution given the low testing and contact tracing, and presumably reporting capacity, by the South World countries. Nevertheless, Southern people are living under minimal healthcare, consequently, their relative wellness amidst the COVID-19 crisis could not be overlooked. The observed differences in infectivity, however, might not be ethnically-biased but most likely they could be due to the differences in the living standard, healthcare systems as well as the lifestyle of Global North versus Global South countries. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Lifestyle, Health organization, global South, global north, COVID-19, epidemiological disparity Identifier An unambiguous reference to the resource within a given context DOI: 10.4081/gc.2020.9025 Source A related resource from which the described resource is derived Geriatric Care Publisher An entity responsible for making the resource available PAGEPress Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Geriatrics https://www.socictopen.socict.org/files/original/f7043cc19fc85f7ba1abf16b4c23732c.pdf 15ff2127fdb28193b1cf299ee2654df9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ophthalmology in the time of COVID-19: experience from Hong Kong Eye Hospital Creator An entity primarily responsible for making the resource Carmen K. M. Chan, Victoria W. Y. Wong, Clement C.Y. Tham, Stephanie S. L. Cheung, Hunter K. L. Yuen, Chi Wai Tsang, Jason C K Chan, Cherie Y.K. Wong, N.M. Lam Description An account of the resource AIM: To review international guidelines and to share our infection control experience during the coronavirus disease 2019 (COVID-19) pandemic at a tertiary eye centre in Hong Kong.METHODS: Infection control guidelines and recommendations from international ophthalmological bodies are reviewed and discussed. The measures at our hospital were drawn up as per international and local health authorities’ guidelines and implemented with the collaboration of doctors, nurses and administrative staff.RESULTS: The aims of our infection control measures are to 1) minimize cross-infection within the hospital; 2) protect and support hospital staff; 3) ensure environmental control. To minimize the risk of cross-infection, outpatient attendance and elective surgery have been reduced by 40%, and general anesthesia procedures were reduced by 90%. Patients entering the hospital are screened for fever, travel history, contact and cluster history, and COVID-19 related symptoms. To protect and support hospital staff, we ensure provision of adequate personal protective equipment (PPE) and provide clear guidelines on the level of PPE needed, depending on the clinical situation. Other protective measures include provision of work uniforms, easy access to alcohol-based hand rub, opening new lunch areas, implementation of self-monitoring and self-reporting systems, and communication via online education and updates. Finally, environmental control is achieved by ensuring regular disinfection of the hospital premise, enhancing ventilation, and usage of disposable ophthalmic instruments.CONCLUSION: Our multi-pronged approach to infection control is, so far, successful in minimizing infection risks, while allowing the maintenance of essential ophthalmic services. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource -, Hong Kong, infection control, coronavirus, Ophthalmology, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.18240/ijo.2020.06.01 Source A related resource from which the described resource is derived International Journal of Ophthalmology Publisher An entity responsible for making the resource available Press of International Journal of Ophthalmology (IJO PRESS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Ophthalmology https://www.socictopen.socict.org/files/original/e4fe5c467c19bf7808d9d4a3e307ddb3.pdf 9f89c8d047792d2dd94137a63f3cc1bd Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes Creator An entity primarily responsible for making the resource Jingyuan Fu, Cisca Wijmenga, Alexandra Zhernakova, Lude Franke, Patrick Deelen, LifeLines Cohort study, Morris Swertz, Serena Sanna, Esteban A. Lopera Maya, Adriaan van der Graaf, Pauline Lanting, Marije van der Geest Description An account of the resource Coronavirus disease 2019 (COVID-19) shows a wide variation in expression and severity of symptoms, from very mild or no symptoms, to flu-like symptoms, and in more severe cases, to pneumonia, acute respiratory distress syndrome, and even death. Large differences in outcome have also been observed between males and females. The causes for this variability are likely to be multifactorial, and to include genetics. The SARS-CoV-2 virus responsible for the infection depends on two human genes: the human receptor angiotensin converting enzyme 2 (ACE2) for cell invasion, and the serine protease TMPRSS2 for S protein priming. Genetic variation in these two genes may thus modulate an individual's genetic predisposition to infection and virus clearance. While genetic data on COVID-19 patients is being gathered, we carried out a phenome-wide association scan (PheWAS) to investigate the role of these genes in other human phenotypes in the general population. We examined 178 quantitative phenotypes including cytokines and cardio-metabolic biomarkers, as well as usage of 58 medications in 36,339 volunteers from the Lifelines population cohort, in relation to 1,273 genetic variants located in or near ACE2 and TMPRSS2. While none reached our threshold for significance, we observed several interesting suggestive associations. For example, single nucleotide polymorphisms (SNPs) near the TMPRSS2 genes were associated with thrombocytes count (p = 1.8 × 10−5). SNPs within the ACE2 gene were associated with (1) the use of angiotensin II receptor blockers (ARBs) combination therapies (p = 5.7 × 10−4), an association that is significantly stronger in females (pdiff = 0.01), and (2) with the use of non-steroid anti-inflammatory and antirheumatic products (p = 5.5 × 10−4). While these associations need to be confirmed in larger sample sizes, they suggest that these variants could play a role in diseases such as thrombocytopenia, hypertension, and chronic inflammation that are often observed in the more severe COVID-19 cases. Further investigation of these genetic variants in the context of COVID-19 is thus promising for better understanding of disease variability. Full results are available at https://covid19research.nl. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource ACE2, TMPRSS2, PheWAS, NSAIDs (non-steroidal anti-inflammatory drugs), COVID-19, ARBs (angiotensin II receptor blockers) Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fgene.2020.00613 Source A related resource from which the described resource is derived Frontiers in Genetics Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics https://www.socictopen.socict.org/files/original/df7c860aa043a96678abfd425db8e512.pdf f09d2bbcd3f39c87983d0f873a1454fb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Management of Hemoglobin Disorders During the COVID-19 Pandemic Creator An entity primarily responsible for making the resource Saeed Anwar, Sanjana Fatema Chowdhury Description An account of the resource The coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has become a global public health concern after being first reported in China and has subsequently spread worldwide. It causes mild to severe respiratory illness with some flu-like symptoms. The causal virus behind this disease, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), conceivably attacks the receptors of the respiratory system of the human body but has no strict evidence of attacking the blood cells yet. However, patients with hemoglobin disorders (e.g., sickle cell anemia, thalassemia) are vulnerable to this global health situation due to their clinical complications. Such patients are generally more prone to viral and bacterial infections, which can worsen their physical condition. Some of these patients present immunocompromised conditions, e.g., splenectomized or post-transplant patients. Therefore, they should follow some preventive steps such as shielding as well as the general guidelines for the COVID-19 pandemic. Transfusion dependent patients require regular monitoring for iron overload, and iron chelation therapy may be stopped by the physician depending on the situation. This article reviews the management strategies and provides some crucial recommendations for people in the corner with hemoglobin disorders. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource hemoglobin, Hemoglobinopathies, thalassemia, iron chelation therapy, sickle cell diseases, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmed.2020.00306 Source A related resource from which the described resource is derived Frontiers in Medicine Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General)