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                  <text>Dominio científico: Coronavirus</text>
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                <text>Real-time reverse transcription loop-mediated isothermal amplification for rapid detection of SARS-CoV-2</text>
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                <text>Yee Ling Lau, Ilyiana Ismail, Nur Izati Mustapa, Meng Yee Lai, Tuan Suhaila Tuan Soh, Afifah Hassan, Kalaiarasu M. Peariasamy, Yee Leng Lee, Yoong Min Chong, I-Ching Sam, Pik Pin Goh</text>
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                <text>Background Highly sensitive real-time reverse transcription polymerase chain reaction (RT-qPCR) methods have been developed for the detection of SARS-CoV-2. However, they are costly. Loop-mediated isothermal amplification (LAMP) assay has emerged as a novel alternative isothermal amplification method for the detection of nucleic acid. Methods A rapid, sensitive and specific real-time reverse transcription LAMP (RT-LAMP) assay was developed for SARS-CoV-2 detection. Results This assay detected one copy/reaction of SARS-CoV-2 RNA in 30 min. Both the clinical sensitivity and specificity of this assay were 100%. The RT-LAMP showed comparable performance with RT-qPCR. Combining simplicity and cost-effectiveness, this assay is therefore recommended for use in resource resource-limited settings.</text>
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                <text>2020</text>
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                <text>covid-19, Diagnosis, RT-LAMP, rapid detection</text>
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                <text>10.7717/peerj.9278</text>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                <text>High neutrophil to lymphocyte ratio as a prognostic marker in COVID-19 patients.</text>
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                <text>Gustavo D Pimentel, Maria C M Dela Vega, Alessandro Laviano</text>
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                <text>Systemic inflammation has been reported as a new predictor for COVID-19 outcomes. Thus, we highlight in this viewpoint the importance of the neutrophil to lymphocyte ratio in COVID-19 pandemic-infected patients.</text>
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                <text>2020</text>
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                <text>inflammation, covid-19, Lymphocytes, neutrophil</text>
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                <text>10.1016/j.clnesp.2020.08.004</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Clinical nutrition ESPEN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 y vulnerabilidad social Análisis descriptivo de una serie de casos del gran Bueno Aires</text>
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                <text>Malena González, Lucía Ameri, Laura Muñoz, Juan Pedro Luzuriaga, Marina Pifano, Vanesa Velázquez, Betina Zucchino, Mariana Specogna, Santiago Pesci, Enio García, Yamila Comes</text>
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                <text>INTRODUCCIÓN: La morbimortalidad por la enfermedad por el nuevo coronavirus (COVID-19) constituye un problema de salud pública en la Provincia de Buenos Aires y en el resto de Argentina. Las poblaciones con vulnerabilidad social están expuestas a riesgos de manera potenciada. OBJETIVO: Describir la evolución de los casos confirmados de COVID-19 en el Gran Buenos Aires, localizados en zonas con diferentes características sociales categorizadas por vulnerabilidad socioterritorial, desde el inicio de la pandemia hasta el 15 de julio de 2020. MÉTODOS: Estudio descriptivo de corte transversal. Las variables analizadas fueron sexo, edad, evolución de la enfermedad y domicilio categorizado por medio del índice de vulnerabilidad socioterritorial (IVST). RESULTADOS: La mayor cantidad de casos positivos para COVID-19 se encontró en el grupo etario de 20 a 59 años, y el 48% fueron mujeres. El 47% de los casos estudiados residían en zonas vulnerables. El 28% de los casos confirmados requirieron internación. Se internaron en unidades de cuidados intensivos el 3,8% del total de los casos confirmados. Los casos de residentes en zonas no vulnerables tuvieron mayor requerimiento de cuidados intensivos. La letalidad fue de 3,5%, mayor en los varones, y más elevada en residentes de zonas no vulnerables, con una diferencia estadísticamente significativa respecto a los pertenecientes a zonas vulnerables. En la distribución por grupos etarios, se observó un exceso de letalidad estadísticamente significativo en menores de 60 años. DISCUSIÓN: Se observó un número mayor de internaciones en UCI y en la letalidad del grupo de población residente en territorio no vulnerable.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2021</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="39065">
                <text>Revista Argentina de Salud Pública</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="39066">
                <text>Ministerio de Salud</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Public aspects of medicine, Medicine (General)</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Obesity and COVID-19</text>
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            <name>Creator</name>
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              <elementText elementTextId="39069">
                <text>Domenico Azzolino, Matteo Cesari</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="39070">
                <text>2020</text>
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            <description>The topic of the resource</description>
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                <text>inflammation, SARS-CoV-2, nutrition, aging, body mass index, Sarcopenic obesity</text>
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            <name>Identifier</name>
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                <text>10.3389/fendo.2020.581356</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Diseases of the endocrine glands. Clinical endocrinology</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Assisting beginners in root cause analysis operations: analysis and recommendations regarding the spread of COVID-19 in nursing facilities for the elderly</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="39077">
                <text>Hitoshi Tsuchiya</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Background To analyse a medical accident, much time and experience are needed. However, people without experience in analysis have difficulty understanding its conditions and methods, and as a result it takes longer to establish countermeasures. It must be noted that understanding conditions by simply aligning occurrences in the accident in a chronological order is difficult.Purpose A workflow chart that considers time was proposed so that individuals without adequate experience in analysis could easily carry out root cause analysis.Methods In the ‘workflow chart (WFC)’, the time sequence was described horizontally. On the vertical axis, the business manual, the occurrence of the accident, and the time of the occurrence are displayed. In the bottom column of patient event, information regarding damage to patients was written in accordance with time axis. Regarding the degree of damage, the time of error until the accident was identified was connected using a straight line (when the patient was not affected, a dotted line was used) in order to show the overall picture of the accident.Results According to the time flow chart, hints to identify potential risks were proposed. Focus was placed not only on the error event, but also on keywords such as manual inadequacy, time gap, degree of error and so on to easily lead to the question ‘why?’ To visualise this, I proposed an operation flow chart. By using time-WFC, even beginners can easily develop accident countermeasure strategies.Conclusion Using a WFC that considers time, time of error and the occurrence of accident could be visualised. As a result, even individuals without experience in analysis could easily perform an analysis.</text>
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                <text>2020</text>
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            <name>Identifier</name>
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                <text>10.1136/bmjoq-2020-000960</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine (General)</text>
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                <text>MAINTENANCE OF THE MOLDOVAN BANKING SECTOR STABILITY IN THE CONTEXT OF COVID-19 PANDEMIC</text>
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                <text>Anastasia BEJAN</text>
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                <text>The COVID-19 pandemic has distortedthe economic situation around the world,affecting the incomes of enterprises andconsumers. This fact also influences thefinancial situation of banks, given the keyrole of the banking system in accumulatingtemporarily free money from the economyand investing these resources in loans.In the current situation, the CentralBanks’ efforts from all over the world areaimed at ensuring the stability of the bankingsector, maintaining the financial intermediationand the functions of banks, aswell as mitigating the potential effects ofslowing economic growth.The present article examines themeasures taken by the Central Banks of theEuropean Union to mitigate the effects ofthe COVID-19 pandemic, the actions takenby the National Bank of Moldova in thiscontext and as well the measures needed tobe taken forwards by the commercial banksto preserve their capital and liquidity.</text>
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                <text>covid-19, risk, stability, financial crisis, central bank, banking sector</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Economics as a science</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>All Aboard! Getting Faculty Mobilized for Emergency Online Teaching</text>
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                <text>Robin K. Morgan, Patrick A. Lach, Lisa M. Russell</text>
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                <text>This reflective essay describes steps taken by Business faculty in a U.S. Midwestern mid-sized regional university to assist faculty in making the rapid transition to 100% online teaching. These steps include the development of an online course template within the university’s course management system made available to all faculty with tips and video tutorials specifically tailored to business courses. The coronavirus pandemic forced faculty members at institutions across the world into teaching online in about two weeks. Many tenure-track professors and full-time instructors, who were required to complete extensive training prior to teaching online courses, were relatively well-prepared. In spite of this training, some instructors felt overwhelmed when the pandemic forced an immediate transition online. Adjunct instructors and some junior faculty were particularly affected. Consistent with the conservation of resources theory which suggests that individuals conserve their limited resources (e.g., time, money, etc.) to ensure availability when they are most needed, many instructors, particularly adjunct and junior faculty, were constrained by competing demands. Adjunct instructors often teach limited courses while maintaining full-time employment in their respective fields. Junior faculty also have limited resources due to service and publishing demands. The availability of a special online course helped these vulnerable faculty members make the rapid transition to emergency online teaching. This reflective essay also describes the results of a survey about this transition among both faculty and center for teaching and learning (CTL) staff. Lastly, we recommend strategies for CTLs and academic departments to prepare for future crises. “Deputizing” power-users in each academic unit to redistribute workloads during emergencies and sharing tips and tricks customized for their departments is one such strategy. Creating annual online training modules is another strategy to allow seamless transition to unexpected online teaching.</text>
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                <text>2021</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Theory and practice of education</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Building Student Communities in Spite of the Pandemic</text>
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                <text>Viola Ardeni, Sara Dallavalle, Karolina Serafin</text>
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                <text>In times when the Humanities at large have suffered reductions in enrollments, the ability to build student communities has been seminal to the survival of many departments. Building student communities for language departments in particular includes planning conversation hours, movie nights, and cultural events aimed at attracting students and raising retention rates. The Covid-19 pandemic has forced departments across the country to modify not only their course formats, but also the events offered outside of the regular teaching schedule. In this article, we will discuss the shift that the Italian Language Program at Indiana University Bloomington decided to apply to our community building activities during and after the transition from in-person to an online mode of instruction. In order to translate several events planned for the rest of the spring semester into an online environment, we had to resort to the extensive use of social media, such as Instagram and Facebook. Moreover, it was necessary to find creative ways to completely rethink our outreach efforts while still being relevant. Through a tight collaboration among language instructors, we invented and implemented a series of new activities (such as online bingo and cooking lessons) as well as translated those that were crucial for our program to exist and thrive into an online environment. A Karaoke Project that was originally intended to be the highlight of the academic year presented the greatest challenge in organization and modification; and yet, with creativity and an open-minded attitude, we managed to successfully finish the project with high student participation.</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Theory and practice of education</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Spine Surgery: Precautions and Strategies to Minimize Perioperative Risks Amid COVID-19 Outbreak</text>
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                <text>Tzong-Jing Wang, Manabu Ito</text>
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                <text>Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic that has shocked the world. It has brought severe socioeconomic disruptions on a global scale that is unprecedented. On the frontline, the medical world is facing mounting pressure and challenges to clinical work. During this escalating worldwide crisis, spine care providers around the world are needing accurate and precise information on how surgical safety for themselves and the patients can be ensured. With the ultimate objective of formulating a standardized work process for spine practices, this article aimed to summarize some key principles from various international recommendations/consensus and combined evidence- and experience-based practice from medical communities around the world.</text>
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                <text>2020</text>
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                <text>covid-19, spine surgery, perioperative precautions</text>
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                <text>10.22603/ssrr.2020-0076</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Surgery</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China [version 2; peer review: 2 approved]</text>
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                <text>Robert L. Kruse</text>
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                <text>A novel coronavirus (2019-nCoV) originating in Wuhan, China presents a potential respiratory viral pandemic to the world population. Current efforts are focused on containment and quarantine of infected individuals. Ultimately, the outbreak could be controlled with a protective vaccine to prevent 2019-nCoV infection. While vaccine research should be pursued intensely, there exists today no therapy to treat 2019-nCoV upon infection, despite an urgent need to find options to help these patients and preclude potential death. Herein, I review the potential options to treat 2019-nCoV in patients, with an emphasis on the necessity for speed and timeliness in developing new and effective therapies in this outbreak. I consider the options of drug repurposing, developing neutralizing monoclonal antibody therapy, and an oligonucleotide strategy targeting the viral RNA genome, emphasizing the promise and pitfalls of these approaches. Finally, I advocate for the fastest strategy to develop a treatment now, which could be resistant to any mutations the virus may have in the future. The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain (ACE2-Fc), providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity. The ACE2-Fc therapy would also supplement decreased ACE2 levels in the lungs during infection, thereby directly treating acute respiratory distress pathophysiology as a third mechanism of action. The sequence of the ACE2-Fc protein is provided to investigators, allowing its possible use in recombinant protein expression systems to start producing drug today to treat patients under compassionate use, while formal clinical trials are later undertaken. Such a treatment could help infected patients before a protective vaccine is developed and widely available in the coming months to year(s).</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.12688/f1000research.22211.2</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Biotemas</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Universidade Federal de Santa Catarina</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Science, Medicine</text>
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