460 10 20655 https://www.socictopen.socict.org/files/original/9c0865ad5673ddcbc70c7a40e99e0632.pdf ef741b736dd3b46e44b875573a4429cc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus infections in hospitalized pediatric patients with acute respiratory tract disease Creator An entity primarily responsible for making the resource Lusa Lara, Petrovec Miroslav, Krivec Uros, Jevšnik Monika, Uršič Tina, Žigon Nina Description An account of the resource Abstract Background Acute viral respiratory infections are an important cause of morbidity and mortality in humans worldwide. The etiological backgrounds of these infections remain unconfirmed in most clinical cases. The aim of this study was to estimate the prevalence of human coronavirus infections in a series of children hospitalized with symptoms of acute respiratory tract disease in a one-year period in Slovenia. Methods The 664 specimens from 592 children under six years of age hospitalized at the University Children’s Hospital in Ljubljana were sent for the routine laboratory detection of respiratory viruses. Respiratory viruses were detected with a direct immunofluorescence assay and human coronaviruses were detected with a modified real-time RT–PCR. Results HCoV RNA was detected in 40 (6%, 95% CI: 4.3%–8.1%) of 664 samples. Of these specimens, 21/40 (52.5%) were identified as species HKU1, 7/40 (17.5%) as OC43, 6/40 (15%) as 229E, and 6/40 (15%) as NL63. Infection with HCoV occurred as a coinfection with one or more other viruses in most samples (70%). Of the HCoV-positive children, 70.3% had lower respiratory tract infections. Conclusion The results of our study show that HCoV are frequently detected human pathogens, often associated with other respiratory viruses and acute respiratory tract infections in hospitalized children. An association between age and the viral load was found. The highest viral load was detected in children approximately 10 months of age. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource human coronavirus, Hospitalized children, respiratory viral infection Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2334-12-365 Source A related resource from which the described resource is derived BMC Infectious Diseases Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases https://www.socictopen.socict.org/files/original/d1fad06d68d6eb5d16018f12f4ded1cc.pdf ef741b736dd3b46e44b875573a4429cc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus infections in hospitalized pediatric patients with acute respiratory tract disease Creator An entity primarily responsible for making the resource Jevšnik Monika, Uršič Tina, Žigon Nina, Lusa Lara, Krivec Uroš, Petrovec Miroslav Description An account of the resource Abstract Background Acute viral respiratory infections are an important cause of morbidity and mortality in humans worldwide. The etiological backgrounds of these infections remain unconfirmed in most clinical cases. The aim of this study was to estimate the prevalence of human coronavirus infections in a series of children hospitalized with symptoms of acute respiratory tract disease in a one-year period in Slovenia. Methods The 664 specimens from 592 children under six years of age hospitalized at the University Children’s Hospital in Ljubljana were sent for the routine laboratory detection of respiratory viruses. Respiratory viruses were detected with a direct immunofluorescence assay and human coronaviruses were detected with a modified real-time RT–PCR. Results HCoV RNA was detected in 40 (6%, 95% CI: 4.3%–8.1%) of 664 samples. Of these specimens, 21/40 (52.5%) were identified as species HKU1, 7/40 (17.5%) as OC43, 6/40 (15%) as 229E, and 6/40 (15%) as NL63. Infection with HCoV occurred as a coinfection with one or more other viruses in most samples (70%). Of the HCoV-positive children, 70.3% had lower respiratory tract infections. Conclusion The results of our study show that HCoV are frequently detected human pathogens, often associated with other respiratory viruses and acute respiratory tract infections in hospitalized children. An association between age and the viral load was found. The highest viral load was detected in children approximately 10 months of age. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource human coronavirus, respiratory viral infection, Hospitalized children Identifier An unambiguous reference to the resource within a given context 10.1186/1471-2334-12-365 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases https://www.socictopen.socict.org/files/original/af98cdd169d85fed23aa429b4db9d8f9.pdf a0fc39bd40082b4797d0bd157332ca30 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Infections: a Threat to Humanity from the Middle East Caused by MERS-CoV? Creator An entity primarily responsible for making the resource O.K. Duda, L.P. Kotsiubailo Description An account of the resource This article describes epidemic situation in terms of diseases caused by coronaviruses, pathogenic for humans. Clinical features and principles of laboratory diagnostics of coronaviruses are presented. Epidemiological situation in the world in terms of Middle East respiratory syndrome caused by MERS-CoV, which forced the professionals to significantly increase the levels of epidemiological risk of coronaviruses, is analyzed. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource coronavirus infections, Middle East respiratory syndrome (MERS-CoV), SARS-CoV, diagnosis Identifier An unambiguous reference to the resource within a given context DOI: 10.22141/2312-413x.3.08.2015.78694 Source A related resource from which the described resource is derived Aktualʹnaâ Infektologiâ Publisher An entity responsible for making the resource available Publishing House Zaslavsky Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN, RU, UK https://www.socictopen.socict.org/files/original/83a7ca9878901547ca0f4fdc0ed95ba6.pdf dc28a08360f3104cdbc64cf15e3043d8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Infections: a Threat to Humanity from the Middle East Caused by MERS-CoV? Creator An entity primarily responsible for making the resource O.K. Duda, L.P. Kotsiubailo Description An account of the resource This article describes epidemic situation in terms of diseases caused by coronaviruses, pathogenic for humans. Clinical features and principles of laboratory diagnostics of coronaviruses are presented. Epidemiological situation in the world in terms of Middle East respiratory syndrome caused by MERS-CoV, which forced the professionals to significantly increase the levels of epidemiological risk of coronaviruses, is analyzed. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource coronavirus infections, Middle East respiratory syndrome (MERS-CoV), SARS-CoV, diagnosis Identifier An unambiguous reference to the resource within a given context DOI: 10.22141/2312-413x.3.08.2015.78694 Source A related resource from which the described resource is derived Aktualʹnaâ Infektologiâ Publisher An entity responsible for making the resource available Publishing House Zaslavsky Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN, RU, UK https://www.socictopen.socict.org/files/original/6b708b667e847411c3723d0005066bfb.pdf b1386748cbc4f6d1f26471e7ad8367ca Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses Creator An entity primarily responsible for making the resource Alimuddin Zumla, Didier Raoult, Guido Kroemer, Giuseppe Ippolito, Franco Locatelli Description An account of the resource Coronaviruses (CoVs) are a large family of enveloped, positive-strand RNA viruses. Four human CoVs (HCoVs), the non-severe acute respiratory syndrome (SARS)-like HCoVs (namely HCoV 229E, NL63, OC43, and HKU1), are globally endemic and account for a substantial fraction of upper respiratory tract infections. Non-SARS-like CoV can occasionally produce severe diseases in frail subjects but do not cause any major (fatal) epidemics. In contrast, SARS like CoVs (namely SARS-CoV and Middle-East respiratory syndrome coronavirus, MERS-CoV) can cause intense short-lived fatal outbreaks. The current epidemic caused by the highly contagious SARS-CoV-2 and its rapid spread globally is of major concern. There is scanty knowledge on the actual pandemic potential of this new SARS-like virus. It might be speculated that SARS-CoV-2 epidemic is grossly underdiagnosed and that the infection is silently spreading across the globe with two consequences: (i) clusters of severe infections among frail subjects could haphazardly occur linked to unrecognized index cases; (ii) the current epidemic could naturally fall into a low-level endemic phase when a significant number of subjects will have developed immunity. Understanding the role of paucisymptomatic subjects and stratifying patients according to the risk of developing severe clinical presentations is pivotal for implementing reasonable measures to contain the infection and to reduce its mortality. Whilst the future evolution of this epidemic remains unpredictable, classic public health strategies must follow rational patterns. The emergence of yet another global epidemic underscores the permanent challenges that infectious diseases pose and underscores the need for global cooperation and preparedness, even during inter-epidemic periods. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Epidemiology, immunology, coronavirus, MERS-CoV, SARS-CoV, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.15698/cst2020.04.216 Source A related resource from which the described resource is derived Cell Stress Publisher An entity responsible for making the resource available Shared Science Publishers OG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Medicine https://www.socictopen.socict.org/files/original/eff50550658e55700d1f1616ddbd4ab1.pdf f4a8823462b38de78c1f6a15bdee4bfe Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines. Creator An entity primarily responsible for making the resource Roland Züst, Luisa Cervantes-Barragan, Thomas Kuri, Gjon Blakqori, Friedemann Weber, Burkhard Ludewig, Volker Thiel Description An account of the resource Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the coding sequence of the non-structural protein 1 (nsp1). In cell culture, nsp1 of mouse hepatitis virus (MHV), like its SARS-coronavirus homolog, strongly reduced cellular gene expression. The effect of nsp1 on MHV replication in vitro and in vivo was analyzed using a recombinant MHV encoding a deletion in the nsp1-coding sequence. The recombinant MHV nsp1 mutant grew normally in tissue culture, but was severely attenuated in vivo. Replication and spread of the nsp1 mutant virus was restored almost to wild-type levels in type I interferon (IFN) receptor-deficient mice, indicating that nsp1 interferes efficiently with the type I IFN system. Importantly, replication of nsp1 mutant virus in professional antigen-presenting cells such as conventional dendritic cells and macrophages, and induction of type I IFN in plasmacytoid dendritic cells, was not impaired. Furthermore, even low doses of nsp1 mutant MHV elicited potent cytotoxic T cell responses and protected mice against homologous and heterologous virus challenge. Taken together, the presented attenuation strategy provides a paradigm for the development of highly efficient coronavirus vaccines. Date A point or period of time associated with an event in the lifecycle of the resource 2007 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.0030109 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/56dbca1c03ea2ddc46740689110198c0.pdf 9bcc58f3926a5430abdc32e248a01632 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus nucleocapsid proteins assemble constitutively in high molecular oligomers Creator An entity primarily responsible for making the resource Yingying Cong, Franziska Kriegenburg, Cornelis A. M. de Haan, Fulvio Reggiori Description An account of the resource Abstract Coronaviruses (CoV) are enveloped viruses and rely on their nucleocapsid N protein to incorporate the positive-stranded genomic RNA into the virions. CoV N proteins form oligomers but the mechanism and relevance underlying their multimerization remain to be fully understood. Using in vitro pull-down experiments and density glycerol gradients, we found that at least 3 regions distributed over its entire length mediate the self-interaction of mouse hepatitis virus (MHV) and severe acute respiratory syndrome coronavirus (SARS-CoV) N protein. The fact that these regions can bind reciprocally between themselves provides a possible molecular basis for N protein oligomerization. Interestingly, cytoplasmic N molecules of MHV-infected cells constitutively assemble into oligomers through a process that does not require binding to genomic RNA. Based on our data, we propose a model where constitutive N protein oligomerization allows the optimal loading of the genomic viral RNA into a ribonucleoprotein complex via the presentation of multiple viral RNA binding motifs. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Identifier An unambiguous reference to the resource within a given context 10.1038/s41598-017-06062-w Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine https://www.socictopen.socict.org/files/original/e12ea8c11f677943fb5a41d5cd1438a4.pdf c08fb8e51419132c7d54d5a4a490069a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Outbreak in Italy: Physiological Benefits of Home-Based Exercise During Pandemic Creator An entity primarily responsible for making the resource Giuseppe Musumeci, Silvia Ravalli Description An account of the resource The Coronavirus Disease 2019 (COVID-19) pandemic has forced the hardest-hit populations, like Italians, to radically change their daily habits, starting with social distancing, strict preventive measures, and self-isolation. These precautions also apply to sport-related facilities and activities. The difficulty to practice physical activity during this dramatic moment in time adds to the risks associated with sedentary habits, due to staying all the time at home. Here, the importance and the benefits of maintaining exercise routine, even at home, are emphasized in order to avoid the consequences of inactivity. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Health, prevention, physical activity, inactivity, home based exercise, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/jfmk5020031 Source A related resource from which the described resource is derived Journal of Functional Morphology and Kinesiology Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the musculoskeletal system https://www.socictopen.socict.org/files/original/309cfd4d30dd6d081db454419f7bf3cc.pdf 66fd3fc89ffbfb6c75ac0d9fb88f1cc6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Pandemic (SARS-COV-2): Pre-Exercise Screening Questionnaire (PESQ) for Telepresential Exercise Creator An entity primarily responsible for making the resource Leônidas de Oliveira Neto, Vagner Deuel de Oliveira Tavares, Felipe Barreto Schuch, Kênio Costa Lima Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource exercise telehealth, COVID-19, Behavior, ehealth, Questionnaire Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fpubh.2020.00146 Source A related resource from which the described resource is derived Frontiers in Public Health Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/5a0a462bd2c9bed2f26177a3622f5b64.pdf d11ad3ef39cd0c53fd8d0d84c156e63d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Pandemic a Factor in Delayed Mourning in Survivors: A Letter to The Editor Creator An entity primarily responsible for making the resource Maryam Sajadian, Seyed Mohammad Hossein Javadi Description An account of the resource This article has no abstract. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, delayed mourning, virtual mourning Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Publisher An entity responsible for making the resource available Arak Medical University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General), Medicine