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                <text>Italy is the European country that was hit first and hardest by the COVID-19 epidemic. Since February 2020, the outbreak of the epidemic disease in Italy, with fatal outcomes in up to 10% of cases, made it urgent to implement extraordinary measures to avoid a breakdown of the universal Italian national health system. The update for April 1, 2020, in Italy recorded 102,669 confirmed COVID-19 cases, with a median patient age of 63 years. The deceased patients were older people (median age 80 years) and often had a cancer diagnosis (about 20%). Thus, in the extraordinary epidemiological scenario of the COVID-19 pandemic in Italy, older persons in cancer treatment are at particularly high risk of being severely affected by COVID-19. These people face a health- and economics-related emergency that also carries cultural and ethical implications. In accordance with the measures adopted by the Italian government to limit viral transmission, several associations of Italian oncologists have taken action to update Elderly Cancer Care programs. In view of the newly emerging needs, we herein outline practical suggestions aimed at guaranteeing the best continuity to elderly cancer patients.</text>
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                <text>DOI: 10.3389/fonc.2020.00648</text>
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                <text>Frontiers in Oncology</text>
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                <text>DOI: 10.1186/s12916-020-01556-3</text>
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                <text>Noam Bosak, Mohamed Khateb, Maryam Muqary</text>
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                <text>SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not explained by respiratory etiologies. Interestingly, previous studies in animal models emphasized the neurotropism of coronaviruses; thus, these CNS manifestations of COVID-19 are not surprising. This minireview scans the literature regarding the involvement of the CNS in coronavirus infections in general, and in regard to the recent SARS-CoV-2, specifically.</text>
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                <text>DOI: 10.3389/fneur.2020.00715</text>
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                <text>SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not explained by respiratory etiologies. Interestingly, previous studies in animal models emphasized the neurotropism of coronaviruses; thus, these CNS manifestations of COVID-19 are not surprising. This minireview scans the literature regarding the involvement of the CNS in coronavirus infections in general, and in regard to the recent SARS-CoV-2, specifically.</text>
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                <text>10.3389/fneur.2020.00715</text>
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                <text>Neurology. Diseases of the nervous system</text>
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                <text>Muhammad Bilal, Hafiz  M. N. Iqbal, Muhammad Imran Khan, Ishtiaq Ahmed, Muhammad  Shahzad Nazir</text>
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                <text>Despite the earlier two Coronavirus outbreaks, this appearance of the third Coronavirus outbreak hasbrought several complications and now emerged as a human-health related pandemic issue. The widegeographical spread and transmissibility of newly emerged novel-Coronavirus (2019-nCoV) and severityof coronavirus disease 2019 (COVID-19) raised serious concerns about the future trajectory of the 2019-nCoV/COVID-19 outbreak. Herein, we have briefly covered some important aspects of the 2019-nCoV/COVID-19 outbreak to highlight the need to learn lessons for a safer future. First, an epidemiologicalcomparison of respiratory viral infections with particular reference to 2019-nCoV is given with relevantexamples. Following that, considering the earlier two Coronavirus outbreaks, the emergence of anothernew 2019-nCoV is given. Finally, the lesson learned, so far, and key concerns for pandemic impactassessment at large and COVID-19, in particular, are discussed for future considerations.</text>
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                <text>DOI: 10.22207/JPAM.14.SPL1.09</text>
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                <text>Journal of Pure and Applied Microbiology</text>
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                <text>Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity.</text>
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                <text>Mark R. Denison, Everett Clinton Smith</text>
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                <text>DOI: 10.1371/journal.ppat.1003760</text>
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                <text>PLoS Pathogens</text>
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                <text>Biology (General), Immunologic diseases. Allergy</text>
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                <text>Coronaviruses in avian species – review with focus on epidemiology and diagnosis in wild birds</text>
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                <text>Miłek Justyna, Blicharz-Domańska Katarzyna</text>
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                <text>Coronaviruses (CoVs) are a large group of enveloped viruses with a single-strand RNA genome, which continuously circulate in mammals and birds and pose a threat to livestock, companion animals, and humans. CoVs harboured by avian species are classified to the genera gamma- and deltacoronaviruses. Within the gamma-CoVs the main representative is avian coronavirus, a taxonomic name which includes the highly contagious infectious bronchitis viruses (IBVs) in chickens and similar viruses infecting other domestic birds such as turkeys, guinea fowls, or quails. Additionally, IBVs have been detected in healthy wild birds, demonstrating that they may act as the vector between domestic and free-living birds. Moreover, CoVs other than IBVs, are identified in wild birds, which suggests that wild birds play a key role in the epidemiology of other gammaCoVs and deltaCoVs. Development of molecular techniques has significantly improved knowledge of the prevalence of CoVs in avian species. The methods adopted in monitoring studies of CoVs in different avian species are mainly based on detection of conservative regions within the viral replicase, nucleocapsid genes, and 3’UTR or 5’UTR. The purpose of this review is to summarise recent discoveries in the areas of epidemiology and diagnosis of CoVs in avian species and to understand the role of wild birds in the virus distribution.</text>
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                <text>DOI: 10.2478/jvetres-2018-0035</text>
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                <text>Coronaviruses in Children, Greece</text>
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                <text>Anna Papa, Evangelia Papadimitriou, Luciano Kleber de Souza Luna, Motassim Al Masri, Efimia Souliou, Maria Eboriadou, Antonis Antoniadis, Sung Sup Park</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>EN</text>
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