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                <text>The ongoing Corona Virus Disease-2019 (COVID-19) pandemic has reminded all the stakeholders that infectious diseases cannot be restrained within geographical boundaries. The urgent need to have a vaccine for the novel viral infection justifies the role which immunization plays in safeguarding the human lives and economic growth of a nation. Amidst the implementation of outbreak readiness and response activities, it is important to realize that the delivery of the routine immunization programs becomes even more crucial than earlier times. In conclusion, as the fight against the COVID-19 infection intensifies in the different parts of the world, there is a simultaneous pressing need to protect all age-groups from vaccine-preventable diseases through immunization, which will in turn play a crucial role in the sustainability of the health care systems.</text>
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                <text>The Corona Virus Disease-2019 (COVID-19) pandemic has been declared as a Public Health Emergency of International Concern and its overall risk of transmission at global level has also been increased to very high based on the recent trends of the disease. It is the need of the hour to strengthen international traffic regulations, if we really want to limit the onward spread of the infection to other nations. The recent recommendations released by the World Health Organization does not support travel or trade restrictions in nations which are reporting cases. Acknowledging all these facts and understanding about the disease as it continues to evolve, the best approach for the containment of the infection is to increase the awareness level of travellers about the preventive measures and to obtain the health declaration from travellers at the time of arrival. In conclusion, for the containment of COVID-19 outbreak and for minimizing the risk of further transmission, strengthening of the international traffic regulations will play a critical role.</text>
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                <text>La enfermería de salud mental se centra en el cuidado a partir de las relaciones interpersonales, es guiada por un marco teórico y metodológico propio que la convierten en una profesión autónoma. La pandemia por COVID-19 ha afectado la salud mental de muchas personas poniendo a prueba todos los niveles de atención de la salud. Por lo que en este artículo se busca describir las realidades, los avances y los desafíos para la enfermería de salud mental después de la pandemia por COVID-19. Se exponen algunos elementos que podrían mejorar la calidad de los servicios en esta área, dentro de los que se mencionan el desarrollo de: Investigación en e-salud, enfermería de salud mental en el hospital general, cuidado remoto, manejo del duelo, medios de comunicación y cooperación en equipo. La enfermería de salud mental debe aprovechar los desafíos que genera la pandemia por COVID-19 para innovar su ejercicio profesional basado en evidencia científica.</text>
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                <text>2020</text>
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                <text>coronavirus, Salud mental, Enfermería, Atención de enfermería</text>
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                <text>Ciencia y Cuidado</text>
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                <text>Universidad Francisco de Paula Santander</text>
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                <text>Medical emergencies. Critical care. Intensive care. First aid, Nursing</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Viral Ubiquitin and Ubiquitin-Like Deconjugases—Swiss Army Knives for Infection</text>
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                <text>Maria Grazia Masucci</text>
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                <text>Posttranslational modifications of cellular proteins by covalent conjugation of ubiquitin and ubiquitin-like polypeptides regulate numerous cellular processes that are captured by viruses to promote infection, replication, and spreading. The importance of these protein modifications for the viral life cycle is underscored by the discovery that many viruses encode deconjugases that reverse their functions. The structural and functional characterization of these viral enzymes and the identification of their viral and cellular substrates is providing valuable insights into the biology of viral infections and the host’s antiviral defense. Given the growing body of evidence demonstrating their key contribution to pathogenesis, the viral deconjugases are now recognized as attractive targets for the design of novel antiviral therapeutics.</text>
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                <text>coronavirus, type-I IFN, Herpesvirus, innate immunity, ubiquitin-like deconjugase, virus cycle</text>
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                <text>Epidemiology and Health</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="43426">
                <text>Microbiology</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    </elementSetContainer>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>THE ROLE OF THE US IN FINDING A SOLUTION TO THE CURRENT ANGLOPHONE CRISIS IN CAMEROON</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43428">
                <text>Emmanuel Jabea Eluke</text>
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          </element>
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            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43429">
                <text>The Anglophone Crisis is a conflict in the Southern Cameroons region of Cameroon, part of the long-standing Anglophone problem. The purpose of this study is to analyze the origin of the Anglophone problem in Cameroon. Equally, to identify and analyze the causes of the present Anglophone crisis in Cameroon and the rule of the US in finding a solution to the crisis. Research method was based on analyzing policy documents of US, Cameroon and the separatist of the Anglophone regions. Following up latest developments of the crisis was another main method used in the study. In September 2017, separatists in the Anglophone territories of Northwest Region and Southwest Region (collectively known as Southern Cameroons) declared the independence of Ambazonia and began fighting against the Government of Cameroon. Starting as a low-scale insurgency, the conflict spread to most parts of the Anglophone regions within a year. By the summer of 2019, the government controlled the major cities and parts of the countryside, while the separatists held parts of the countryside and regularly appeared in the major cities. The war has killed approximately 3,000 people and forced more than half a million people to flee their homes. Although 2019 has seen the first known instance of dialogue between Cameroon and the separatists, as well as a state-organized national dialogue and the granting of a special status to the Anglophone regions, the war continued to intensify in late 2019. The February 2020 Cameroonian parliamentary election brought further escalation, as the separatists became more assertive while Cameroon deployed additional forces. While the COVID-19 pandemic saw one armed group (SOCADEF) declare a unilateral ceasefire to combat the spread of the virus, other groups and the Cameroonian government ignored calls to follow suit and kept on fighting. With the enormous pressure by the US on the Cameroonian government, the government of Cameroon has not yet heed the call to stop fighting with the rebels of the Anglophone regions.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43430">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="43431">
                <text>Cameroon, U.S, protest, anglophone crisis</text>
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            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="43432">
                <text>10.15421/352022</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="43433">
                <text>Філософія та політологія в контексті сучасної культури</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="43434">
                <text>Oles Honchar Dnipro National University</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="43435">
                <text>Philosophy (General), Political science</text>
              </elementText>
            </elementTextContainer>
          </element>
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  <item itemId="4816" public="1" featured="0">
    <fileContainer>
      <file fileId="4816">
        <src>https://www.socictopen.socict.org/files/original/3674eee4497ed78fce0c11d2b42a2641.pdf</src>
        <authentication>b9019307d4d6217934860343f0730117</authentication>
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        <elementSet elementSetId="1">
          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43436">
                <text>COVID-19 IN ITALY. CLINICAL EMERGENCY AND BIOETHICAL PERSPECTIVES</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43437">
                <text>Luigi Cardia</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43438">
                <text>Italy is the European country with the second highest number of novel Coronavirus disease 19 (COVID-19) deaths. Several factors interfered with the spread of this phenomenon, both clinical, political, and bioethical. In this scenario, where the need for care goes far beyond the capacity of a health system able to cope with it, what should be the criteria for an equitable distribution of the available resources? The mass quarantine required physical distancing in order to limit the spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and contextually created additional problems for the organization Italian National Health Service. The delicate ethical questions posed by the current emergency are beginning to unveil some proposals for solutions in literature, which, although still insufficient for understandable reasons, is increasing.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43439">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43440">
                <text>Italy, Bioethics, emergency, Coronavirus disease-19 (COVID-19)</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="43441">
                <text>10.3269/1970-5492.2020.15.30</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="43442">
                <text>Euromediterranean Biomedical Journal</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="43443">
                <text>Associazione Italiana Giovani Medici</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="43444">
                <text>Medicine (General)</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
  <item itemId="4817" public="1" featured="0">
    <fileContainer>
      <file fileId="4817">
        <src>https://www.socictopen.socict.org/files/original/b1f25538b161b79c076b03c73dfc8969.pdf</src>
        <authentication>e4416d70d7bddfd33cbb99e1fd0084b8</authentication>
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      <elementSetContainer>
        <elementSet elementSetId="1">
          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43445">
                <text>Brief Report: Hydroxychloroquine does not induce hemolytic anemia or organ damage in a “humanized” G6PD A- mouse model</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43446">
                <text>Benjamin E. Zuchelkowski, Ling Wang, Sebastien Gingras, Qinzi Xu, Minying Yang, Darrell Triulzi, Grier P. Page, Victor R. Gordeuk, Daniel B. Kim-Shapiro, Janet S. Lee, Mark T. Gladwin, Patrick G. Gallagher</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43447">
                <text>Background Hydroxychloroquine (HCQ) is widely used in the treatment of malaria, rheumatologic disease such as lupus, and most recently, COVID-19. These uses raise concerns about its safe use in the setting of glucose-6-phosphate dehydrogenase (G6PD) deficiency, especially as 11% of African American men carry the G6PD A- variant. However, limited data exist regarding the safety of HCQ in this population. Study design and methods Recently, we created a novel “humanized” mouse model containing the G6PD deficiency A- variant (Val68Met) using CRISPR technology. We tested the effects of high-dose HCQ administration over 5 days on hemolysis in our novel G6PD A- mice. In addition to standard hematologic parameters including plasma hemoglobin, erythrocyte methemoglobin, and reticulocytes, hepatic and renal function were assessed after HCQ. Results Residual erythrocyte G6PD activity in G6PD A- mice was ~6% compared to wild-type (WT) littermates. Importantly, we found no evidence of clinically significant intravascular hemolysis, methemoglobinemia, or organ damage in response to high-dose HCQ. Conclusions Though the effects of high doses over prolonged periods was not assessed, this study provides early, novel safety data of the use of HCQ in the setting of G6PD deficiency secondary to G6PD A-. In addition to novel safety data for HCQ, to our knowledge, we are the first to present the creation of a “humanized” murine model of G6PD deficiency.</text>
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            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43448">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="43449">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="43450">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="43451">
                <text>Science, Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
  <item itemId="4818" public="1" featured="0">
    <fileContainer>
      <file fileId="4818">
        <src>https://www.socictopen.socict.org/files/original/5396819be6a346daa1fbcff0be4d89e0.pdf</src>
        <authentication>67aaf1e696f9552f16308b7c90ec85f3</authentication>
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        <elementSet elementSetId="1">
          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43452">
                <text>Impact of the COVID-19 epidemic on patterns of pregnant women’s perception of threat and its relationship to mental state: A latent class analysis</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43453">
                <text>Mengsha Qi, Xiaozhe Li, Shuyun Liu, Yonghong Li, Wei Huang, Vijayaprasad Gopichandran</text>
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            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43454">
                <text>Objective The objective of this study was to define the threatened perception types of pregnant women during the COVID-19 pandemic and determine the correlations between the perception types and their demographic factors, their preventive knowledge of COVID-19 and their mental status in order to provide suggestions for pregnant women during pandemic. Methods Latent class analysis were used to explore the optimal numbers of clusters. Multinomial logistic regression and multiple correspondence analysis were used to analyze the demographic variables of the latent categories. MANOVA was used to analyze the difference of knowledge of COVID-19 obtained among clusters and their psychological status, and chi-square test was used determine the relationship between the latent clusters and the participant’s COVID-19 worry level. Results Five clusters were found: the first cluster (n = 120, 39%) was unthreatened and confident. Cluster 2(n = 84, 28%) was unthreatened but not confident. Cluster 3 (n = 49, 17%) was threatened but confident. Cluster 4 (n = 25, 9%) was threaten, not confident and knowledgeable, and Cluster 5 (n = 20, 7%) was threatened, not confident and lacking knowledge. Three demographic variables were shown an effect on the classification, they were support from work, family support and intrapartum and postpartum complications. Conclusion This study can help assess the mental health risks of pregnant women during an epidemic. The results could be helpful for families, work units, communities and medical institutions to make targeted intervention decisions for pregnant women.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43455">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="43456">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="43457">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="43458">
                <text>Science, Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
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  <item itemId="4819" public="1" featured="0">
    <fileContainer>
      <file fileId="4819">
        <src>https://www.socictopen.socict.org/files/original/d7681236c969596ebb736f4276fd49ed.pdf</src>
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        <elementSet elementSetId="1">
          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43459">
                <text>Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43460">
                <text>Bertram Pitt, Nadia R Sutton, Zhong Wang, Sascha N Goonewardena, Michael Holinstat</text>
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            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43461">
                <text>There is a need for therapeutic approaches to prevent and mitigate the effects of Coronavirus Disease (2019) (COVID-19). The histone deacetylase (HDAC) inhibitor valproic acid, which has been available for the therapy of epilepsy for many years, is a drug that could be repurposed for patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This article will review the reasons to consider valproic acid as a potential therapeutic to prevent severe COVID-19. Valproic acid could reduce angiotensin-converting enzyme 2 and transmembrane serine protease 2 expression, required for SARS-CoV-2 viral entry, and modulate the immune cellular and cytokine response to infection, thereby reducing end-organ damage. The combined anti-thrombotic, anti-platelet, and anti-inflammatory effects of valproic acid suggest it could be a promising therapeutic target for COVID-19.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43462">
                <text>2021</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43463">
                <text>severe acute respiratory syndrome, covid-19, acute respiratory distress syndrome, Valproic acid, Histone deacetylase inhibitor</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="43464">
                <text>10.1016/j.ejphar.2021.173988</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="43465">
                <text>European journal of pharmacology</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
