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                <text>Dong Hyun Kim, Eun Young Cho, Soo-Han Choi, Han Wool Kim, Ji-Man Kang</text>
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                <text>Coronavirus disease-2019 (COVID-19), which started in Wuhan, China, in December 2019 and declared a worldwide pandemic on March 11, 2020, is a novel infectious disease that causes respiratory illness and death. Pediatric COVID-19 accounts for a small percentage of patients and is often milder than that in adults; however, it can progress to severe disease in some cases. Even neonates can suffer from COVID-19, and children may spread the disease in the community. This review summarizes what is currently known about COVID-19 in children and adolescents.</text>
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                <text>coronavirus, child, covid-19, newborn, Infant</text>
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                <text>10.3345/cep.2020.00535</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Korean clinical practice guidelines for preventing transmission of coronavirus disease 2019 (COVID-19) in hemodialysis facilities</text>
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                <text>Dong Ki Kim, Yon Su Kim, Hayne Cho Park, Do Hyoung Kim, Kyung Don Yoo, Yang-Gyun Kim, Sang-Ho Lee, Hye Eun Yoon, Seong Nam Kim, Myeong Sung Kim, Yoon Chul Jung, Young-Ki Lee, The Korean Society of Nephrology COVID-19 Task Force Team</text>
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                <text>Coronavirus disease 2019 (COVID-19) is a highly contagious viral disease that is caused by the novel virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). COVID-19 has become pandemic since December 2019, when the first case developed in Wuhan, China. Patients receiving hemodialysis are more vulnerable to viral transmission because their immune functions are impaired and they receive treatment within a narrow space. Calling on previous experience with Middle East Respiratory Syndrome during the 2015 outbreak, the joint committee of the Korean Society of Nephrology and the Korean Society of Dialysis Therapy quickly formed a COVID-19 task force team to develop a manual before the first index case was diagnosed in the hemodialysis unit. This special article introduces clinical practice guidelines to prevent secondary transmission of COVID-19 within hemodialysis facilities, which were developed to protect patients, healthcare workers, and caregivers from this highly transmissible virus. The areas of infection control covered by these guidelines include standard precautions, performing dialysis therapy for confirmed or suspected cases, performing cohort isolation for contact patients, and disease monitoring and contact surveillance. We hope these guidelines help healthcare workers and hemodialysis patients around the world cope with the COVID-19 pandemic.</text>
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                <text>2020</text>
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                <text>Infection control, covid-19, practice guideline, hemodialysis units</text>
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                <text>10.23876/j.krcp.20.046</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Internal medicine, Specialties of internal medicine</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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        <name>Dublin Core</name>
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            <name>Title</name>
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                <text>Using patient-collected clinical samples and sera to detect and quantify the severe acute respiratory syndrome coronavirus (SARS-CoV)</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Dong Qingming, Zhao Chunhui, ZHUANG Hui, He Zhongping, Peng Guoai, Dwyer Dominic E</text>
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            <description>An account of the resource</description>
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                <text>Abstract Background Severe acute respiratory syndrome (SARS) caused a large outbreak of pneumonia in Beijing, China, in 2003. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect and quantify SARS-CoV in 934 sera and self-collected throat washes and fecal samples from 271 patients with laboratory-confirmed SARS managed at a single institution. Results SARS-CoV detection rates in sera were highest in the first 9 days of illness, whereas detection was highest in throat washes 5–14 days after onset of symptoms. The highest SARS-CoV RT-PCR rates (70.4–86.3%) and viral loads (log10 4.5–6.1) were seen in fecal samples collected 2–4 weeks after the onset of clinical illness. Fecal samples were frequently SARS-CoV RT-PCR positive beyond 40 days, and occasional sera still had SARS-CoV detected after 3 weeks of illness. Conclusion In the context of an extensive outbreak with major pressure on hospital resources, patient self-collected samples are an alternative to nasopharyngeal aspirates for laboratory confirmation of SARS-CoV infection.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2007</text>
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            <name>Identifier</name>
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                <text>DOI: 10.1186/1743-422X-4-32</text>
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                <text>Virology Journal</text>
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                <text>BMC</text>
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                <text>Infectious and parasitic diseases</text>
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                <text>EN</text>
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                <text>Structural Factors of the Middle East Respiratory Syndrome Coronavirus Outbreak as a Public Health Crisis in Korea and Future Response Strategies</text>
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                <text>Dong-Hyun Kim</text>
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                <text>The recent Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak has originated from a failure in the national quarantine system in the Republic of Korea as most basic role of protecting the safety and lives of its citizens. Furthermore, a number of the Korean healthcare system’s weaknesses seem to have been completely exposed. The MERS-CoV outbreak can be considered a typical public health crisis in that the public was not only greatly terrorized by the actual fear of the disease, but also experienced a great impact to their daily lives, all in a short period of time. Preparedness for and an appropriate response to a public health crisis require comprehensive systematic public healthcare measures to address risks comprehensively with an all-hazards approach. Consequently, discussion regarding establishment of post-MERS-CoV improvement measures must focus on the total reform of the national quarantine system and strengthening of the public health infrastructure. In addition, the Korea Centers for Disease Control and Prevention must implement specific strategies of action including taking on the role of “control tower” in a public health emergency, training of Field Epidemic Intelligence Service officers, establishment of collaborative governance between central and local governments for infection prevention and control, strengthening the roles and capabilities of community-based public hospitals, and development of nationwide crisis communication methods.</text>
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                <text>2015</text>
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                <text>DOI: 10.3961/jpmph.15.066</text>
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                <text>Journal of Preventive Medicine and Public Health</text>
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                <text>To characterize genetic variation of severe acute respiratory syndrome–associated coronavirus (SARS-CoV) transmitted in the Beijing area during the epidemic outbreak of 2003, we sequenced 29 full-length S genes of SARS-CoV from 20 hospitalized SARS patients on our unit, the Beijing 302 Hospital. Viral RNA templates for the S-gene amplification were directly extracted from raw clinical samples, including plasma, throat swab, sputum, and stool, during the course of the epidemic in the Beijing area. We used a TA-cloning assay with direct analysis of nested reverse transcription–polymerase chain reaction products in sequence. One hundred thirteen sequence variations with nine recurrent variant sites were identified in analyzed S-gene sequences compared with the BJ01 strain of SARS-CoV. Among them, eight variant sites were, we think, the first documented. Our findings demonstrate the coexistence of S-gene sequences with and without substitutions (referred to BJ01) in samples analyzed from some patients.</text>
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                <text>Los coronavirus son una amplia familia de virus patógenos que pueden causar diversas afecciones, principalmente respiratorias, tanto en humanos como en animales vertebrados domésticos y salvajes. Pueden producir desde el resfriado común leve, uno severo y hasta enfermedades más graves, como ocurre con el Coronavirus 2 responsable del actual síndrome respiratorio agudo severo (SARS-CoV-2), más conocido como Covid-19, que corresponde al nombre la enfermedad y que tiene en vilo al planeta (1,2).</text>
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                <text>DOI: 10.24188/recia.v12.n1.2020.769</text>
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                <text>Revista Colombiana de Ciencia Animal Recia</text>
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                <text>Universidad de Sucre</text>
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                <text>Agriculture (General), Agriculture, Animal culture</text>
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                <text>Use of Drotrecogin Alfa (Activated) in a Severe Acute Respiratory Syndrome Patient with Severe Sepsis</text>
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                <text>Donna McRitchie, Warda Farooq, Harold N Fisher</text>
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                <text>DOI: 10.1155/2008/501759</text>
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              <elementText elementTextId="27397">
                <text>Canadian Journal of Infectious Diseases and Medical Microbiology</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Hindawi Limited</text>
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                <text>Infectious and parasitic diseases, Microbiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Harmonisation of maternal health biorepositories in sub-Saharan Africa.</text>
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              <elementText elementTextId="71994">
                <text>Donna Russell</text>
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                <text>BMJ global health</text>
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                <text>Models to inform neutralizing antibody therapy strategies during pandemics: the case of SARS-CoV-2.</text>
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                <text>Donovan Guttieres, Anthony  J. Sinskey, Stacy  L. Springs</text>
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                <text>Neutralizing antibodies (nAbs) against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can play an important role in reducing impacts of the COVID-19 pandemic, complementing ongoing public health efforts such as diagnostics and vaccination. Rapidly designing, manufacturing and distributing nAbs requires significant planning across the product value chain and an understanding of the opportunities, challenges and risks throughout. A systems framework comprised of four critical components is presented to aid in developing effective end-to-end nAbs strategies in the context of a pandemic: (1) product design and optimization, (2) epidemiology, (3) demand and (4) supply. Quantitative models are used to estimate product demand using available epidemiological data, simulate biomanufacturing operations from typical bioprocess parameters and calculate antibody production costs to meet clinical needs under various realistic scenarios. In a US-based case study during the 9-month period from March 15 to December 15, 2020, the projected number of SARS-CoV-2 infections was 15.73 million. The estimated product volume needed to meet therapeutic demand for the maximum number of clinically eligible patients ranged between 6.3 and 31.5 tons for 0.5 and 2.5 g dose sizes, respectively. The relative production scale and cost needed to meet demand are calculated for different centralized and distributed manufacturing scenarios. Meeting demand for anti-SARS-CoV-2 nAbs requires significant manufacturing capacity and planning for appropriate administration in clinical settings. MIT Center for Biomedical Innovation's data-driven tools presented can help inform time-critical decisions by providing insight into important operational and policy considerations for making nAbs broadly accessible, while considering time and resource constraints.</text>
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                <text>epidemiology, neutralizing antibodies, pandemic response, Product design, biomanufacturing</text>
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                <text>Antibody therapeutics</text>
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                <text>Kesepian Remaja Pada Masa Pandemi COVID-19</text>
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                <text>Dony Darma Sagita, Dede  Hermawan</text>
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                <text>The COVID-19 pandemic is a complex problem in the life of Indonesian society today, including aspects of individual personality. The purpose of this study was to empirically examine the level of adolescent loneliness during the COVID-19 pandemic. This study used quantitative method research with a descriptive approach. The sample were 300 adolescents that selected by convenience sampling technique. The results showed that the level of loneliness of adolescents during the COVID-19 pandemic was in a quite high category with a proportion of 43%, 10% in high category, and 1,7% in very high category. It means the adolescent need to be more attention so that teenagers can lead a normal life in their daily lives.</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>loneliness, Adolescent, the Covid-19 pandemic</text>
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                <text>10.32505/enlighten.v3i2.1892</text>
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                <text>Enlighten</text>
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                <text>Institut Agama Islam Negeri Langsa</text>
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                <text>Psychology, Philosophy of religion. Psychology of religion. Religion in relation to other subjects</text>
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