66 10 20655 https://www.socictopen.socict.org/files/original/42ac2f26a3b859238b6b8caba55b1c70.pdf 920d530041e403c335d4fa5558eac4ef Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Physicist View of COVID-19 Airborne Infection through Convective Airflow in Indoor Spaces Creator An entity primarily responsible for making the resource Luis Alfredo Anchordoqui, Eugene M. Chudnovsky Description An account of the resource General Idea: Naturally produced droplets from humans (such as those produced by breathing, talking, sneezing, and coughing) include several types of cells (e.g., epithelial cells and cells of the immune system), physiological electrolytes contained in mucous and saliva (e.g. Na+, K+, Cl-), as well as, potentially, several infectious agents (e.g. bacteria, fungi, and viruses). In response to the novel coronavirus SARS-CoV-2 epidemic, which has become a major public health issue worldwide, we provide a concise overview of airborne germ transmission as seen from a physics perspective. We also study whether coronavirus aerosols can travel far from the immediate neighbourhood and get airborne with the convective currents developed within confined spaces. Methodology: Methods of fluid dynamics are utilized to analyse the behavior of various-size airborne droplets containing the virus. Study Findings: We show that existing vortices in the air can make a location far away from the source of the virus be more dangerous than a nearby (e.g., 6 feet away) location. Practical Implications: Our study reveals that it seems reasonable to adopt additional infection-control measures to the recommended 6 feet social distancing. We provide a recommendation that could help to slow down the spread of the virus. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, novel coronavirus, Airborne infection, indoor spaces Identifier An unambiguous reference to the resource within a given context 10.28991/SciMedJ-2020-02-SI-5 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens https://www.socictopen.socict.org/files/original/a916ba429c6217be69a33686874ccdce.pdf 0121019d6f501a75d4769c193d077978 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Physics Modeling Study of COVID-19 Transport in Air Creator An entity primarily responsible for making the resource Luis Alfredo Anchordoqui, James B. Dent, Thomas J. Weiler Description An account of the resource Objectives: Health threat from COVID-19 airborne infection has become a public emergency of international concern. During the ongoing coronavirus pandemic, people have been advised by the Centers for Disease Control and Prevention to maintain social distancing of at least 2 m to limit the risk of exposure to the coronavirus. Experimental data, however, show that infected aerosols and droplets trapped inside a turbulent puff cloud can travel 7 to 8 m. We carry out a physics modeling study for COVID-19 transport in air. Methodology: We propose a nuclear physics analogy-based modeling of the complex gas cloud and its payload of pathogen-virions. We estimate the puff effective stopping range adapting the high-energy physics model that describes the slow down of α-particles (in matter) via interactions with the electron cloud. Analysis Findings: We show that the cloud stopping range is proportional to the diameter of the puff times its density. We use our puff model to determine the average density of the buoyant fluid in the turbulent cloud. A fit to the experimental data yields , where  and  are the average density of the puff and the air. We demonstrate that temperature variation could cause an O (≲ ±8%) effect in the puff stopping range for extreme ambient cold or warmth. We also demonstrate that aerosols and droplets can remain suspended for hours in the air. Therefore, once the puff slows down sufficiently, and its coherence is lost, the eventual spreading of the infected aerosols becomes dependent on the ambient air currents and turbulence. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource aerosol, covid-19, SARS-CoV-2, Transport, Airborne infection Identifier An unambiguous reference to the resource within a given context 10.28991/SciMedJ-2020-02-SI-7 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens https://www.socictopen.socict.org/files/original/5d33a86260dc455b60243296c55d9ec2.pdf 273c5bd41ff9e2682f338931794c5643 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Pilot-Scale Supercritical Carbon Dioxide Extraction to Valorize Colombian Mango Seed Kernel Creator An entity primarily responsible for making the resource Leidy J. Cerón-Martínez, Andrés M. Hurtado-Benavides, Alfredo Ayala-Aponte, Liliana Serna-Cock, Diego F. Tirado Description An account of the resource Colombian mango production, which exceeded 261,000 t in 2020, generates about 40% of the whole fruit as solid waste, of which more than 50% are seed kernels (over 52,000 t solid by-product); though none is currently used for commercial purposes. This study reports the results of the supercritical carbon dioxide (scCO2) extraction of an oil rich in essential fatty acids (EFAs) from revalorized mango seed kernels and the optimization of the process by the Response Surface Methodology (RSM). In pilot-scale scCO2 experiments, pressure (23 MPa–37 MPa) and temperature (52 °C–73 °C) were varied, using 4.5 kg of CO2. The highest experimental oil extraction yield was 83 g/kg (37 MPa and 63 °C); while RSM predicted that 84 g/kg would be extracted at 35 MPa and 65 °C. Moreover, by fine-tuning pressure and temperature it was possible to obtain an EFA-rich lipid fraction in linoleic (37 g/kg) and α-linolenic (4 g/kg) acids, along with a high oleic acid content (155 g/kg), by using a relatively low extraction pressure (23 MPa), which makes the process a promising approach for the extraction of oil from mango waste on an industrial scale, based on a circular economy model. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource <i>Mangifera indica</i> L, circular economy, essential fatty acids, fruit by-products, response surface methodology, valorization strategy Identifier An unambiguous reference to the resource within a given context 10.3390/molecules26082279 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Relation A related resource <a href="https://www.mdpi.com/1420-3049/26/8/2279" target="_blank" rel="noreferrer noopener">https://www.mdpi.com/1420-3049/26/8/2279</a> https://www.socictopen.socict.org/files/original/414d19c86f7290b4cdc67688d2b35e80.pdf 6faa404445fe2d29de8e697a89c0f43a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A planarian nidovirus expands the limits of RNA genome size. Creator An entity primarily responsible for making the resource Amir Saberi, Anastasia A Gulyaeva, John L Brubacher, Phillip A Newmark, Alexander E Gorbalenya Description An account of the resource RNA viruses are the only known RNA-protein (RNP) entities capable of autonomous replication (albeit within a permissive host environment). A 33.5 kilobase (kb) nidovirus has been considered close to the upper size limit for such entities; conversely, the minimal cellular DNA genome is in the 100-300 kb range. This large difference presents a daunting gap for the transition from primordial RNP to contemporary DNA-RNP-based life. Whether or not RNA viruses represent transitional steps towards DNA-based life, studies of larger RNA viruses advance our understanding of the size constraints on RNP entities and the role of genome size in virus adaptation. For example, emergence of the largest previously known RNA genomes (20-34 kb in positive-stranded nidoviruses, including coronaviruses) is associated with the acquisition of a proofreading exoribonuclease (ExoN) encoded in the open reading frame 1b (ORF1b) in a monophyletic subset of nidoviruses. However, apparent constraints on the size of ORF1b, which encodes this and other key replicative enzymes, have been hypothesized to limit further expansion of these viral RNA genomes. Here, we characterize a novel nidovirus (planarian secretory cell nidovirus; PSCNV) whose disproportionately large ORF1b-like region including unannotated domains, and overall 41.1-kb genome, substantially extend the presumed limits on RNA genome size. This genome encodes a predicted 13,556-aa polyprotein in an unconventional single ORF, yet retains canonical nidoviral genome organization and expression, as well as key replicative domains. These domains may include functionally relevant substitutions rarely or never before observed in highly conserved sites of RdRp, NiRAN, ExoN and 3CLpro. Our evolutionary analysis suggests that PSCNV diverged early from multi-ORF nidoviruses, and acquired additional genes, including those typical of large DNA viruses or hosts, e.g. Ankyrin and Fibronectin type II, which might modulate virus-host interactions. PSCNV's greatly expanded genome, proteomic complexity, and unique features-impressive in themselves-attest to the likelihood of still-larger RNA genomes awaiting discovery. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1007314 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/5d8c0c97de1768d2a0629f307973ad0c.pdf f8283eae73dfe8e7a4d6c8695e5e9a32 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A pluriatividade das famílias rurais no Nordeste e no Sul do Brasil: pobreza rural e políticas públicas The pluriactivity of rural households in the Brazilian Northeast and South: rural poverty and public policies Creator An entity primarily responsible for making the resource Carlos Alves do Nascimento Description An account of the resource O artigo desfaz a ideia de que as famílias rurais pluriativas encontram ambientes favoráveis ao seu crescimento em regiões com economias locais mais dinâmicas e modernas. A pesquisa está apoiada em informações processadas a partir dos microdados da Pesquisa Nacional por Amostra de Domicílios - PNAD (1992 a 1999 e 2001 a 2005). Defende-se que, no caso da Região Sul, o crescimento (ou o não crescimento) da pluriatividade - e sua influência sobre o conjunto da agricultura familiar - depende fundamentalmente de concepções e ações políticas (políticas públicas). No Nordeste, a pluriatividade cresce associada à pobreza no interior da região.The paper aims to undo the idea that pluriactivity finds favorable environment to its growth in regions with dynamic and modern local economies. The research is based on information processing from the microdata of the Pesquisa Nacional por Amostra de Domicílios - PNAD (from 1992 to 1999 and from 2001 to 2005). This paper also points out that, in the case of the South region, the growth (or not growth) of pluriactivity - and its influence over family farms - depends fundamentally on political conceptions and political actions. In the Northeast, pluriactivity increases associated to poverty in interior areas of the region. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Subject The topic of the resource Pluriatividade agrícola, Políticas Públicas, Public policies, family farm, famílias rurais, pluriactivity, pobreza rural, rural poverty Identifier An unambiguous reference to the resource within a given context 10.1590/S0104-06182009000200004 Source A related resource from which the described resource is derived Economia e Sociedade Publisher An entity responsible for making the resource available Universidade Estadual de Campinas Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Economics as a science, Economic history and conditions Relation A related resource <a href="http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0104-06182009000200004" target="_blank" rel="noreferrer noopener">http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0104-06182009000200004</a> https://www.socictopen.socict.org/files/original/208e1b415e749026174b249b27f40c79.pdf d6b5d32383f9cf78336423f3890ad982 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A política brasileira de segurança alimentar e nutricional: concepção e resultados Creator An entity primarily responsible for making the resource Walter Belik Description An account of the resource O artigo discute a utilização do conceito de Segurança Alimentar e Nutricional no desenho do Projeto Fome Zero e a sua implementação a partir de diversos programas que tiveram início na década passada. Essa política pública é o resultado de uma trajetória histórica e de um novo contexto internacional no qual o combate à fome passou a ser associado ao reconhecimento de direitos por parte do Estado. Após apresentar alguns resultados o artigo conclui chamando a atenção para a necessidade de aperfeiçoar programas ligados ao abastecimento, educação alimentar e nutricional e agricultura urbana, de forma a viabilizar o funcionamento de um sistema integrado de Segurança Alimentar e Nutricional. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource Fome zero. Segurança alimentar e nutricional. Direito humano à alimentação Identifier An unambiguous reference to the resource within a given context 10.20396/san.v19i2.8634614 Source A related resource from which the described resource is derived Revista Segurança Alimentar e Nutricional Publisher An entity responsible for making the resource available Universidade Estadual de Campinas Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Nutrition. Foods and food supply Relation A related resource <a href="https://periodicos.sbu.unicamp.br/ojs/index.php/san/article/view/8634614" target="_blank" rel="noreferrer noopener">https://periodicos.sbu.unicamp.br/ojs/index.php/san/article/view/8634614</a> https://www.socictopen.socict.org/files/original/0e984bfb8cf6cd9af8cf3d45e1043844.pdf ec390df8fe554825babe5b051bd9ee4c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A política de produção das áreas verdes municipais: análise histórica e projetual Creator An entity primarily responsible for making the resource Matheus de Vasconcelos Casimiro, Ana Gabriela Godinho Lima Description An account of the resource A partir do século XX, a Administração Municipal de São Paulo passou a formular planos que norteavam a política para as áreas verdes públicas. Neste artigo discutimos as modificações observadas em duas experiências distintas, ocorridas, respectivamente, em 1974 e 2014. A análise desdobra-se em duas perspectivas: 1. com base em indicadores históricos, fundamentada na leitura de documentos oficiais; e 2. a partir de indicadores projetuais, nos quais são examinadas as práticas projetuais dos arquitetos envolvidos em cada experiência analisada. Para tanto, são descritos os modos como os indicadores foram formulados, bem como seu emprego nesta análise. Os resultados mostram uma tendência histórica de ênfase progressiva nos valores de conservação e recuperação ambiental, e diminuição da importância do papel social dos parques e áreas verdes urbanas, levando a modificações significativas na função do projeto arquitetônico para essas áreas. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource História do planejamento urbano, Indicadores de análise, Pesquisa acadêmica em área de prática projetual, Sistemas de áreas verdes Source A related resource from which the described resource is derived Pós: Revista do Programa de Pós-Graduação em Arquitetura e Urbanismo da FAUUSP Publisher An entity responsible for making the resource available Universidade de São Paulo (USP) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Urban groups. The city. Urban sociology, Architecture Relation A related resource <a href="https://www.revistas.usp.br/posfau/article/view/150212" target="_blank" rel="noreferrer noopener">https://www.revistas.usp.br/posfau/article/view/150212</a> https://www.socictopen.socict.org/files/original/317078a70b2eb501dc7265e3c901b231.pdf 98f72bc32241c53cf46a0dd7b6bbb12c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A post-synaptic scaffold at the origin of the animal kingdom. Creator An entity primarily responsible for making the resource Onur Sakarya, Kathryn A Armstrong, Maja Adamska, Marcin Adamski, I-Fan Wang, Bruce Tidor, Bernard M. Degnan, Todd H Oakley, Kenneth S. Kosik Description An account of the resource The evolution of complex sub-cellular structures such as the synapse requires the assembly of multiple proteins, each conferring added functionality to the integrated structure. Tracking the early evolution of synapses has not been possible without genomic information from the earliest branching animals. As the closest extant relatives to the Eumetazoa, Porifera (sponges) represent a pivotal group for understanding the evolution of nervous systems, because sponges lack neurons with clearly recognizable synapses, in contrast to eumetazoan animals.We show that the genome of the demosponge Amphimedon queenslandica possesses a nearly complete set of post-synaptic protein homologs whose conserved interaction motifs suggest assembly into a complex structure. In the critical synaptic scaffold gene, dlg, residues that make hydrogen bonds and van der Waals interactions with the PDZ ligand are 100% conserved between sponge and human, as is the motif organization of the scaffolds. Expression in Amphimedon of multiple post-synaptic gene homologs in larval flask cells further supports the existence of an assembled structure. Among the few post-synaptic genes absent from Amphimedon, but present in Eumetazoa, are receptor genes including the entire ionotropic glutamate receptor family.Highly conserved protein interaction motifs and co-expression in sponges of multiple proteins whose homologs interact in eumetazoan synapses indicate that a complex protein scaffold was present at the origin of animals, perhaps predating nervous systems. A relatively small number of crucial innovations to this pre-existing structure may represent the founding changes that led to a post-synaptic element. Date A point or period of time associated with an event in the lifecycle of the resource 2007 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0000506 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/268dfbd38c25cf1a4b6b09f454ae1a4f.pdf b49f05e781fa8078c34ec880362ed225 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A potential hypothesis for 2019-nCoV infection therapy through delivery of recombinant ACE2 by red blood cell-hitchhiking Creator An entity primarily responsible for making the resource Zahra Sadat Aghili, Seyed Abbas Mirzaei, Mehdi Banitalebi-Dehkordi Description An account of the resource Abstract A novel infectious disease, caused by 2019 Novel Coronavirus (2019-nCoV) is responsible for the recent outbreak of severe respiratory disease. The 2019-nCoV spread rapidly and reaching epidemic proportions in many countries of the world. ACE2 was identified as a key receptor for 2019-nCoV infections. Excessive form of soluble ACE2 rescues cellular ACE2 activity which has a protective role in acute lung failure and neutralizes the virus. The short half-life of ACE2 is a major limitation to its practical application. Nanoparticle-based drug delivery systems are one of the most widely investigated approaches for developing novel therapies for a variety of diseases. Nevertheless, nanoparticles suffer from the rapid removal from the bloodstream by the reticuloendothelial system (RES). A noncovalent attachment of nanoparticles to RBCs increases their half-life in blood and allows transient accumulation in the lungs, while decreases their uptake by the liver and spleen. Connecting the recombinant ACE2 into the surface of nanoparticles that were attached to RBCs can be a potential therapeutic approach for 2019-nCoV infection through increasing their lung targeting to naturalize the virus and also acting as a bioreactor in the blood circulation to decrease serum level of Angiotensin II and protects lungs from injury/ARDS. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource 2019ncov, ACE2, nanoparticles, Drug Delivery, RBC hitchhiking Identifier An unambiguous reference to the resource within a given context 10.1186/s40709-020-00129-y Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) https://www.socictopen.socict.org/files/original/34e24d5dacf2318efd62588e953acf77.pdf cdfb18775131316dd2697b2ae3dd3d3a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A potential role for Galectin-3 inhibitors in the treatment of COVID-19 Creator An entity primarily responsible for making the resource John L. Caniglia, Maheedhara R. Guda, Swapna Asuthkar, Andrew J. Tsung, Kiran K. Velpula Description An account of the resource The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the causative agent of coronavirus disease 2019 (COVID-19), has been declared a global pandemic by the World Health Organization. With no standard of care for the treatment of COVID-19, there is an urgent need to identify therapies that may be effective in treatment. Recent evidence has implicated the development of cytokine release syndrome as the major cause of fatality in COVID-19 patients, with elevated levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) observed in patients. Galectin-3 (Gal-3) is an animal lectin that has been implicated in the disease process of a variety of inflammatory conditions. Inhibitors of the small molecule Gal-3 have been shown to reduce the levels of both IL-6 and TNF-α in vitro and have shown anti-inflammatory effects in vivo. Additionally, a key domain in the spike protein of β-coronaviridae, a genus which includes SARS-CoV2, is nearly identical in morphology to human Gal-3. These spike proteins are critical for the virus’ entry into host cells. Here we provide a systematic review of the available literature and an impetus for further research on the use of Gal-3 inhibitors in the treatment of COVID-19. Further, we propose a dual mechanism by which Gal-3 inhibition may be beneficial in the treatment of COVID-19, both suppressing the host inflammatory response and impeding viral attachment to host cells. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Cytokines, covid-19, galectin-3 Identifier An unambiguous reference to the resource within a given context 10.7717/peerj.9392 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine