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                <text>A PROPÓSITO DE LA RELACIÓN ECONOMÍA Y MEDIO AMBIENTE: UN BALANCE CRÍTICO SOBRE LAS CONVENCIONES Y TENSIONES EPISTÉMICAS DE LA DISCIPLINA</text>
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                <text>Cortés Landázury Raúl</text>
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                <text>En este artículo, se intenta establecer el grado de influencia de algunas posturas epistemológicas discordantes, como aquellas que provienen de la ecología y de la estructura metodológica y conceptual de la ciencia económica que se ocupa de la problemática del medio ambiente. Desde esta perspectiva, el trabajo examina el sentido de las categorías analíticas a las que ha dado lugar la discusión disciplinar sobre el medio ambiente; expone la controversia de los alcances de la economía en el contexto de los estudios del desarrollo; analiza la economía ecológica como propuesta alternativa, soportada en la noción de paradigma; y señala el grado de avance de las posturas críticas de la corriente dominante.</text>
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                <text>Economia ambiental, Paradigma científico, desarrollo sostenible, economía ecológica</text>
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                <text>Cuadernos de Economía</text>
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                <text>&lt;a href="http://www.revistas.unal.edu.co/index.php/ceconomia/article/view/1084" target="_blank" rel="noreferrer noopener"&gt;http://www.revistas.unal.edu.co/index.php/ceconomia/article/view/1084&lt;/a&gt;</text>
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                <text>A propósito de Michel Serres (Agen, 1930)</text>
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                <text>Luis Alfonso Palau Castaño</text>
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                <text>El número 6 de la revista Ciencias Sociales y Educación del Departamento de Ciencias Sociales y Humanas de la Universidad de Medellín dedica un apartado de la sección de traducciones a textos y entrevistas al filósofo e historiador de las ciencias francés Michel Serres, quien con una prolija obra ha estudiado ámbitos del arte, la matemática, la historia de las religiones, la música, la ecología, laestética, la historia de las ciencias, la comunicación, la antropología, el derecho, la literatura.</text>
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                <text>2014</text>
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                <text>Arte, Michel Serres, analisis, derecho, política</text>
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                <text>Universidad de Medellín, Sello Editorial</text>
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                <text>History of scholarship and learning. The humanities, Social sciences (General)</text>
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                <text>&lt;a href="https://revistas.udem.edu.co/index.php/Ciencias_Sociales/article/view/1025/1055" target="_blank" rel="noreferrer noopener"&gt;https://revistas.udem.edu.co/index.php/Ciencias_Sociales/article/view/1025/1055&lt;/a&gt;</text>
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                <text>A propósito del aniversario de la Revista Finanzas y Política Económica.</text>
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                <text>Joan Miguel Tejedor Estupiñán</text>
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                <text>En el año 2007, la crisis económica mundial se evidenciaba en el desplome del mercado hipotecario del sector financiero en los Estados Unidos, en el año siguiente, esta manifestaba sus primeras consecuencias con la caída de las inversiones, las cuales afectarían directamente la economía real de esta potencia mundial. Esto provocó la reducción del consumo y la inversión, el desequilibrio del comercio internacional, la pérdida de expectativas de crecimiento y la pérdida de la confianza de los consumidores. Como lo afirma Francisco Rojas Aravena (2009), en el 5º informe del secretario general de la Facultad Latino Americana de Ciencias Sociales (Flacso), titulado: Crisis financiera: construyendo una respuesta política latinoamericana, esta crisis no fue un fenómeno aislado, sino un desequilibrio en un contexto de diversas crisis globales, las cuales actualmente se han manifestado de distintas formas en todas las regiones del mundo, incluyendo la región de América Latina y el Caribe. El actual desequilibrio global no solo se manifiesta en los escenarios económicos, sino que también es evidente en la crisis alimentaria, la crisis energética, el cambio climático y las crisis políticas, que han perpetuado guerras y desatado nuevos conflictos en diferentes regiones como en los países del Medio Oriente, África e incluso Colombia, y su histórico conflicto interno de hace más de cinco décadas. El calentamiento global, el peligro de extinción de muchas especies entre ellas la humana, junto con la desigualdad y la violencia ?estas últimas, que son vulneraciones a los derechos humanos? son solo parte de esta realidad que es indispensable superar.</text>
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                <text>2013</text>
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                <text>10.14718/revfinanzpolitecon.v5.n1.2013.450</text>
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                <text>Revista Finanzas y Política Económica</text>
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                <text>Universidad Católica de Colombia</text>
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                <text>Economics as a science, Finance</text>
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                <text>&lt;a href="https://revfinypolecon.ucatolica.edu.co/article/view/450" target="_blank" rel="noreferrer noopener"&gt;https://revfinypolecon.ucatolica.edu.co/article/view/450&lt;/a&gt;</text>
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                <text>A Protracted Course of COVID19 Infection in a Metastatic Breast Cancer Patient During CDK4/6 Inhibitor Therapy</text>
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                <text>Albert Grinshpun, Hila Fruchtman, Irit Merlet, Dean Nachman</text>
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                <text>We describe the first case report of a patient with COVID19 infection and metastatic breast cancer, while on systemic therapy with a CDK4/6 inhibitor. The patient had unique disease course, characterized with delayed symptomatology. The case highlights novel findings and stress careful and extended follow-up during COVID19 infection in patients taking biologic therapies affecting the immune system.</text>
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                <text>Pneumonia, Metastatic breast cancer, palbociclib, CDK4/6 inhibitors, COVID-19</text>
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                <text>DOI: 10.3389/fonc.2020.01085</text>
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                <text>Frontiers in Oncology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Neoplasms. Tumors. Oncology. Including cancer and carcinogens</text>
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                <text>A Public Health Strategy for the COVID-19 Pandemic in Portugal: Learning from International Experience</text>
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                <text>Constantino Sakellarides, Fernando Araújo</text>
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                <text>covid-19, pandemia, Saúde Pública</text>
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                <text>10.20344/amp.14130</text>
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                <text>Acta Médica Portuguesa</text>
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                <text>Ordem dos Médicos</text>
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                <text>Medicine, Medicine (General)</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>A Public Platform for Virtual IoT-Based Monitoring and Tracking of COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Younchan Jung, Ronnel Agulto</text>
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            <description>An account of the resource</description>
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                <text>The world is developing an app that alerts my smartphone when a COVID-19 (COrona VIrus Disease 19) confirmed case comes near me. However, regardless of what will be put to practical use first, the COVID-19 tracking system should satisfy the issues of legalization of location tracking and scalability as a public platform used by the world. Additional problems need solutions related to real-time authentication for information gathering, blind naming and privacy of tracked persons, and quality of service on the Query/Reply procedure. This paper proposes the Software-Defined Networking Controller-centric global public platform to monitor and track information for the COVID-19 relevant people and provide real-time information disclosure services to world-wide Centers for Disease Control and Prevention (CDCs) and regular users. The CDC manages a list of people who needs to be monitored related to the COVID-19 and forcibly installs COVID-19 virtual Internet of Things (vIoT) nodes in the form of applications on their smartphones. In addition to these nodes, the vIoT support nodes also engage as information providers to improve the quality of information services. The design of our platform aims to ensure confidentiality and authentication services giving individually different secret keys. In addition, our platform meets system scalability and reduces Query/Reply latency, where the platform accommodates a large number of world-wide CDCs and persons in control per CDC.</text>
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            <name>Date</name>
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              <elementText elementTextId="68468">
                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="68469">
                <text>covid-19, Tracking, CDC, public platform, virtual IoT</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="68470">
                <text>10.3390/electronics10010012</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="68471">
                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="68472">
                <text>Korean Society of Epidemiology</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="68473">
                <text>Electronics</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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              <elementText elementTextId="11706">
                <text>A putative diacidic motif in the SARS-CoV ORF6 protein influences its subcellular localization and suppression of expression of co-transfected expression constructs</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="11707">
                <text>Gunalan Vithiagaran, Mirazimi Ali, Tan Yee-Joo</text>
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            <description>An account of the resource</description>
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                <text>Abstract Background The ORF6 protein is one of the eight accessory proteins of the severe acute respiratory syndrome coronavirus (SARS-CoV). Numerous properties of ORF6 have been documented and this study focuses on two of these, namely, its ability to suppress the expression of co-transfected expression constructs and its subcellular localization to vesicular structures. Results Using a transient transfection system, ORF6's ability to suppress the expression of co-transfected expression constructs was measured in a quantitative manner. While ORF6 does not have a global effect on protein synthesis, quantitative real-time PCR revealed that it down-regulated the mRNA level of the co-transfected myc-nsp8 gene. Furthermore, alanine substitution of a diacidic cluster motif (aa53-56) in the ORF6 gene caused a reduction in the suppression of expression of co-transfected myc-nsp8 gene. Our previous study revealed that ORF6 localized to vesicular structures in SARS-CoV infected Vero E6 cells. Here, ORF6 was observed to be localized to similar vesicular structures in Vero E6 cells which have been transiently transfected with a mammalian expression plasmid encoding for untagged ORF6. ORF6 showed partial colocalization with cellular proteins CD63 and Lamp1, suggesting that the vesicular structures may be a subpopulation of endosomal/lysosomal vesicles. The alanine substitution of the diacidic cluster motif also altered the subcellular localization of the ORF6 protein, indicating a potential relationship between the subcellular localization of the ORF6 protein and its ability to suppress the expression of co-transfected expression constructs. Conclusions By combining quantitative real-time PCR and transient transfection system, a simple and safe method is established to measure ORF6's ability to suppress the expression of co-transfected myc-nsp8. In addition, immunofluorescence analysis revealed that the subcellular localization of ORF6 when expressed on its own is similar to that observed in SARS-CoV infected cells. Through the use of these two assays, a putative diacidic motif in the ORF6 protein was found to influence its subcellular localization and ability to suppress the expression of co-transfected expression constructs.</text>
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            <name>Date</name>
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              <elementText elementTextId="11709">
                <text>2011</text>
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              <elementText elementTextId="11710">
                <text>DOI: 10.1186/1756-0500-4-446</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="11711">
                <text>BMC Research Notes</text>
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            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="11712">
                <text>BMC</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Biology (General), Science (General), Medicine</text>
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            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="11714">
                <text>EN</text>
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            </elementTextContainer>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
          </elementContainer>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="47227">
                <text>A putative diacidic motif in the SARS-CoV ORF6 protein influences its subcellular localization and suppression of expression of co-transfected expression constructs</text>
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          <element elementId="39">
            <name>Creator</name>
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              <elementText elementTextId="47228">
                <text>Gunalan Vithiagaran, Mirazimi Ali, Tan Yee-Joo</text>
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            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47229">
                <text>Abstract Background The ORF6 protein is one of the eight accessory proteins of the severe acute respiratory syndrome coronavirus (SARS-CoV). Numerous properties of ORF6 have been documented and this study focuses on two of these, namely, its ability to suppress the expression of co-transfected expression constructs and its subcellular localization to vesicular structures. Results Using a transient transfection system, ORF6's ability to suppress the expression of co-transfected expression constructs was measured in a quantitative manner. While ORF6 does not have a global effect on protein synthesis, quantitative real-time PCR revealed that it down-regulated the mRNA level of the co-transfected myc-nsp8 gene. Furthermore, alanine substitution of a diacidic cluster motif (aa53-56) in the ORF6 gene caused a reduction in the suppression of expression of co-transfected myc-nsp8 gene. Our previous study revealed that ORF6 localized to vesicular structures in SARS-CoV infected Vero E6 cells. Here, ORF6 was observed to be localized to similar vesicular structures in Vero E6 cells which have been transiently transfected with a mammalian expression plasmid encoding for untagged ORF6. ORF6 showed partial colocalization with cellular proteins CD63 and Lamp1, suggesting that the vesicular structures may be a subpopulation of endosomal/lysosomal vesicles. The alanine substitution of the diacidic cluster motif also altered the subcellular localization of the ORF6 protein, indicating a potential relationship between the subcellular localization of the ORF6 protein and its ability to suppress the expression of co-transfected expression constructs. Conclusions By combining quantitative real-time PCR and transient transfection system, a simple and safe method is established to measure ORF6's ability to suppress the expression of co-transfected myc-nsp8. In addition, immunofluorescence analysis revealed that the subcellular localization of ORF6 when expressed on its own is similar to that observed in SARS-CoV infected cells. Through the use of these two assays, a putative diacidic motif in the ORF6 protein was found to influence its subcellular localization and ability to suppress the expression of co-transfected expression constructs.</text>
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                <text>2011</text>
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                <text>10.1186/1756-0500-4-446</text>
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                <text>Epidemiology and Health</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="47233">
                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Biology (General), Medicine, Science (General)</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling Approach</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="85501">
                <text>Muhammad  Usman Mirza, Matheus Froeyen, Huda  Ahmed Alghamdi, Hafiz Muzzammel Rehman, Mian Azhar Ahmad, Mahjabeen Saleem, Sarfraz Ahmad, Roquyya Gul, Muhammad Shahbaz Aslam, Muhammad Sajjad, Munir Ahmad Bhinder</text>
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            <description>An account of the resource</description>
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                <text>The outbreak of 2019-novel coronavirus (SARS-CoV-2) that causes severe respiratory infection (COVID-19) has spread in China, and the World Health Organization has declared it a pandemic. However, no approved drug or vaccines are available, and treatment is mainly supportive and through a few repurposed drugs. The urgency of the situation requires the development of SARS-CoV-2-based vaccines. Immunoinformatic and molecular modelling are time-efficient methods that are generally used to accelerate the discovery and design of the candidate peptides for vaccine development. In recent years, the use of multiepitope vaccines has proved to be a promising immunization strategy against viruses and pathogens, thus inducing more comprehensive protective immunity. The current study demonstrated a comprehensive in silico strategy to design stable multiepitope vaccine construct (MVC) from B-cell and T-cell epitopes of essential SARS-CoV-2 proteins with the help of adjuvants and linkers. The integrated molecular dynamics simulations analysis revealed the stability of MVC and its interaction with human Toll-like receptors (TLRs), which trigger an innate and adaptive immune response. Later, the in silico cloning in a known pET28a vector system also estimated the possibility of MVC expression in Escherichia coli. Despite that this study lacks validation of this vaccine construct in terms of its efficacy, the current integrated strategy encompasses the initial multiple epitope vaccine design concepts. After validation, this MVC can be present as a better prophylactic solution against COVID-19.</text>
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                <text>2020</text>
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            <name>Subject</name>
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              <elementText elementTextId="85504">
                <text>Multi-epitope Vaccine, spike protein, covid-19, SARS-CoV-2, molecular modeling</text>
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                <text>A Putative Role of de-Mono-ADP-Ribosylation of STAT1 by the SARS-CoV-2 Nsp3 Protein in the Cytokine Storm Syndrome of COVID-19</text>
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                <text>Jean-Michel Claverie</text>
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                <text>As more cases of COVID-19 are studied and treated worldwide, it had become apparent that the lethal and most severe cases of pneumonia are due to an out-of-control inflammatory response to the SARS-CoV-2 virus. I explored the putative causes of this specific feature through a detailed genomic comparison with the closest SARS-CoV-2 relatives isolated from bats, as well as previous coronavirus strains responsible for the previous epidemics (SARS-CoV and MERS-CoV). The high variability region of the nsp3 protein was confirmed to exhibit the most variations between closest strains. It was then studied in the context of physiological and molecular data available in the literature. A number of convergent findings suggest de-mono-ADP-ribosylation (de-MARylation) of STAT1 by the SARS-CoV-2 nsp3 as a putative cause of the cytokine storm observed in the most severe cases of COVID-19. This may suggest new therapeutic approaches and help in designing assays to predict the virulence of naturally circulating SARS-like animal coronaviruses.</text>
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                <text>inflammation, ACE2, interferon-stimulated gene, PARP14, de-MARylation</text>
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                <text>10.3390/v12060646</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Microbiology</text>
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