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                <text>Yang Yang, M. Elizabeth Halloran, Jonathan D. Sugimoto, Ira M. Longini</text>
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                <text>Highly pathogenic avian influenza A (HPAI) subtype H5N1 has caused family case clusters, mostly in Southeast Asia, that could be due to human-to-human transmission. Should this virus, or another zoonotic influenza virus, gain the ability of sustained human-to-human transmission, an influenza pandemic could result. We used statistical methods to test whether observed clusters of HPAI (H5N1) illnesses in families in northern Sumatra, Indonesia, and eastern Turkey were due to human-to-human transmission. Given that human-to-human transmission occurs, we estimate the infection secondary attack rates (SARs) and the local basic reproductive number, R0. We find statistical evidence of human-to-human transmission (p = 0.009) in Sumatra but not in Turkey (p = 0.114). For Sumatra, the estimated household SAR was 29% (95% confidence interval [CI] 15%–51%). The estimated lower limit on the local R0 was 1.14 (95% CI 0.61–2.14). Effective HPAI (H5N1) surveillance, containment response, and field evaluation are essential to monitor and contain potential pandemic strains.</text>
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                <text>DOI: 10.3201/eid1309.070111</text>
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                <text>Frequent Travelers and Rate of Spread of Epidemics</text>
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                <text>T. Déirdre Hollingsworth, Neil M. Ferguson, Roy M. Anderson</text>
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                <text>A small proportion of air travelers make disproportionately more journeys than the rest of travelers. They also tend to interact predominantly with other frequent travelers in hotels and airport lounges. This group has the potential to accelerate global spread of infectious respiratory diseases. Using an epidemiologic model, we simulated exportation of cases from severe acute respiratory syndrome–like and influenza-like epidemics in a population for which a small proportion travel more frequently than the rest. Our simulations show that frequent travelers accelerate international spread of epidemics only if they are infected early in an outbreak and the outbreak does not expand rapidly. If the epidemic growth rate is high, as is likely for pandemic influenza, heterogeneities in travel are frequently overwhelmed by the large number of infected persons in the majority population and the resulting high probability that some of these persons will take an international flight.</text>
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                <text>DOI: 10.3201/eid1309.070081</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                <text>Coronavirus Antibodies in African Bat Species</text>
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                <text>Marcel A. Müller, Janusz T. Paweska, Patricia A. Leman, Sung Sup Park, Klaus Grywna, Alan Kemp, L.E.O. Braack, Karen Sonnenberg, Matthias Niedrig, Robert Swanepoel</text>
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                <text>Asian bats have been identified as potential reservoir hosts of coronaviruses associated with severe acute respiratory syndrome (SARS-CoV). We detected antibody reactive with SARS-CoV antigen in 47 (6.7%) of 705 bat serum specimens comprising 26 species collected in Africa; thus, African bats may harbor agents related to putative group 4 CoV.</text>
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                <text>2007</text>
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                <text>group 4 coronavirus, SARS-coronavirus, bat, SARS-like coronavirus, zoonosis, reservoir</text>
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                <text>DOI: 10.3201/eid1309.070342</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Elmira T. Isakbaeva, Nino Khetsuriani, R. Suzanne Beard, Angela Peck, Dean D. Erdman, Stephan S. Monroe, Suxiang Tong, Thomas G. Ksiazek, Sara Lowther, Indra Pandya Smith, Larry J. Anderson, Jairam Lingappa, Marc-Alain Widdowson</text>
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                <text>To better assess the risk for transmission of the severe acute respiratory syndrome–associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Laboratory diagnosis of SARS-CoV infection is difficult; thus, sputum and stool specimens should be included in the diagnostic work-up for SARS-CoV infection.</text>
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                <text>2004</text>
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                <text>severe acute respiratory syndrome (SARS), Outbreak, SARS-associated coronavirus, Epidemiology, Transmission, natural history</text>
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                <text>DOI: 10.3201/eid1002.030734</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Susceptibility of Pigs and Chickens to SARS Coronavirus</text>
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                <text>Hana M. Weingartl, John Copps, Michael A Drebot, Peter Marszal, Greg Smith, Jason Gren, Maya Andonova, John Pasick, Paul Kitching, Markus Czub</text>
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                <text>An outbreak of severe acute respiratory syndrome (SARS) in humans, associated with a new coronavirus, was reported in Southeast Asia, Europe, and North America in early 2003. To address speculations that the virus originated in domesticated animals, or that domestic species were susceptible to the virus, we inoculated 6-week-old pigs and chickens intravenously, intranasally, ocularly, and orally with 106 PFU of SARS-associated coronavirus (SARS-CoV). Clinical signs did not develop in any animal, nor were gross pathologic changes evident on postmortem examinations. Attempts at virus isolation were unsuccessful; however, viral RNA was detected by reverse transcriptase-polymerase chain reaction in blood of both species during the first week after inoculation, and in chicken organs at 2 weeks after inoculation. Virus-neutralizing antibodies developed in the pigs. Our results indicate that these animals do not play a role as amplifying hosts for SARS-CoV.</text>
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            <name>Subject</name>
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                <text>severe acute respiratory syndrome, coronavirus, experimental infection, swine, chicken, Canada</text>
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                <text>DOI: 10.3201/eid1002.030677</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>EN</text>
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  <item itemId="744" public="1" featured="0">
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            <element elementId="50">
              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="6986">
                <text>HHS/CDC Legal Response to SARS Outbreak</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="6987">
                <text>James J. Misrahi, Joseph A. Foster, Frederic E. Shaw, Martin S. Cetron</text>
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            <description>An account of the resource</description>
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                <text>Before the severe acute respiratory syndrome (SARS) outbreak, the Centers for Disease Control and Prevention’s (CDC) legal authority to apprehend, detain, or conditionally release persons was limited to seven listed diseases, not including SARS, and could only be changed using a two-step process: 1) executive order of the President of the United States on recommendation by the Secretary, U.S. Department of Health and Human Services (HHS), and 2) amendment to CDC quarantine regulations (42 CFR Parts 70 and 71). In April 2003, in response to the SARS outbreak, the federal executive branch acted rapidly to add SARS to the list of quarantinable communicable diseases. At the same time, HHS amended the regulations to streamline the process of adding future emerging infectious diseases. Since the emergence of SARS, CDC has increased legal preparedness for future public health emergencies by establishing a multistate teleconference program for public health lawyers and a Web-based clearinghouse of legal documents.</text>
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              <elementText elementTextId="6989">
                <text>2004</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="6990">
                <text>law, legal aspects, Lawyers, constitutional law, quarantine, patient isolation</text>
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            </elementTextContainer>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="6991">
                <text>DOI: 10.3201/eid1002.030721</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="6992">
                <text>Emerging Infectious Diseases</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="6993">
                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="6994">
                <text>Infectious and parasitic diseases, Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="6995">
                <text>EN</text>
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  <item itemId="745" public="1" featured="0">
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      <file fileId="745">
        <src>https://www.socictopen.socict.org/files/original/5e7b0fa86191b22130f359d15b98898a.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Severe Acute Respiratory Syndrome, Beijing, 2003</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="6997">
                <text>Wannian Liang, Zonghan Zhu, Jiyong Guo, Zejun Liu, Xiong He, Weigong Zhou, Daniel P. Chin, Anne Schuchat</text>
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            <description>An account of the resource</description>
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                <text>The largest outbreak of severe acute respiratory syndrome (SARS) struck Beijing in spring 2003. Multiple importations of SARS to Beijing initiated transmission in several healthcare facilities. Beijing’s outbreak began March 5; by late April, daily hospital admissions for SARS exceeded 100 for several days; 2,521 cases of probable SARS occurred. Attack rates were highest in those 20–39 years of age; 1% of cases occurred in children 65 years (27.7% vs. 4.8% for those 20–64 years, p &lt; 0.001). Healthcare workers accounted for 16% of probable cases. The proportion of case-patients without known contact to a SARS patient increased significantly in May. Implementation of early detection, isolation, contact tracing, quarantine, triage of case-patients to designated SARS hospitals, and community mobilization ended the outbreak.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="6999">
                <text>2004</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="7000">
                <text>China, Disease Outbreaks, disease transmission, Epidemiology, nosocomial infection, SARS virus</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="7001">
                <text>DOI: 10.3201/eid1001.030553</text>
              </elementText>
            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="7002">
                <text>Emerging Infectious Diseases</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="7003">
                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
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                <text>Infectious and parasitic diseases, Medicine</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>EN</text>
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          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Lack of SARS Transmission among Public Hospital Workers, Vietnam</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="7007">
                <text>Le Dang Ha, Sharon A. Bloom, Nguyen Quang Hien, Susan A. Maloney, Le Quynh Mai, Katrin C. Leitmeyer, Bach Huy Anh, Mary G. Reynolds, Joel M. Montgomery, James A. Comer, Peter W. Horby, Aileen J. Plant</text>
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            <description>An account of the resource</description>
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              <elementText elementTextId="7008">
                <text>The severe acute respiratory syndrome (SARS) outbreak in Vietnam was amplified by nosocomial spread within hospital A, but no transmission was reported in hospital B, the second of two designated SARS hospitals. Our study documents lack of SARS-associated coronavirus transmission to hospital B workers, despite variable infection control measures and the use of personal protective equipment.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="7009">
                <text>2004</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="7010">
                <text>severe acute respiratory syndrome, Vietnam, healthcare personnel</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="7011">
                <text>DOI: 10.3201/eid1002.030707</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="7012">
                <text>Emerging Infectious Diseases</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="7013">
                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="7014">
                <text>Infectious and parasitic diseases, Medicine</text>
              </elementText>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>EN</text>
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  <item itemId="747" public="1" featured="0">
    <fileContainer>
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        <src>https://www.socictopen.socict.org/files/original/4a9b959eb1990d798b63663df3ae838a.pdf</src>
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          <name>Dublin Core</name>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="7016">
                <text>Interferon-β 1a and SARS Coronavirus Replication</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="7017">
                <text>Lisa E. Hensley, Elizabeth A. Fritz, Peter B. Jahrling, Christopher Karp, John W. Huggins, Thomas W. Geisbert</text>
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          <element elementId="41">
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            <description>An account of the resource</description>
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                <text>A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant human interferon (IFN)-β 1a potently inhibits SARS coronavirus replication in vitro.</text>
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              <elementText elementTextId="7019">
                <text>2004</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="7020">
                <text>SARS, interferon, coronavirus, treatment, therapy</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="7021">
                <text>DOI: 10.3201/eid1002.030482</text>
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          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="7022">
                <text>Emerging Infectious Diseases</text>
              </elementText>
            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="7023">
                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                <text>DOI: 10.3201/eid1002.030645</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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