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                <text>Aleksandra Milewska, Kamil Kaminski, Justyna Ciejka, Katarzyna Kosowicz, Slawomir Zeglen, Jacek Wojarski, Maria Nowakowska, Krzysztof Szczubialka, Krzysztof Pyrc</text>
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                <text>To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV-HKU1) circulate worldwide and typically cause the common cold. In most cases, infection with these viruses does not lead to severe disease, although acute infections in infants, the elderly, and immunocompromised patients may progress to severe disease requiring hospitalization. Importantly, no drugs against human coronaviruses exist, and only supportive therapy is available. Previously, we proposed the cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and its hydrophobically-modified derivative (HM-HTCC) as potent inhibitors of the coronavirus HCoV-NL63. Here, we show that HTCC inhibits interaction of a virus with its receptor and thus blocks the entry. Further, we demonstrate that HTCC polymers with different degrees of substitution act as effective inhibitors of all low-pathogenic human coronaviruses.</text>
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                <text>2016</text>
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                <text>DOI: 10.1371/journal.pone.0156552</text>
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                <text>PLoS ONE</text>
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                <text>Reporting of sexually transmitted infections during the COVID-19 pandemic.</text>
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                <text>Aleksandra Popovic, Matthew A Crane, Andrew I Stolbach, Khalil G Ghanem</text>
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                <text>2021</text>
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                <text>epidemiology, Syphilis, Gonorrhoea, Chlamydia Trachomatis, diagnostic screening programmes</text>
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                <text>10.1136/sextrans-2020-054805</text>
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                <text>Predictors Associated with COVID-19 Deaths in Ethiopia</text>
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                <text>Alemu Y</text>
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                <text>Yenew Alemu Department of Statistics, College of Natural and Computational Science, Injibara University, Injibara, EthiopiaCorrespondence: Yenew AlemuCollege of Natural and Computational Science, Injibara University, P.O. Box 40, Injibara, EthiopiaTel +251 920255871Email yenewalemu@gmail.comAbstract: Coronavirus disease is an infectious disease that causes a newly discovered coronavirus. Ethiopia is one of the most impacted countries relative to the proportion of COVID-19 case growth and infection. The purpose of this investigation was to identify the determinants of COVID-19 deaths in Ethiopia. The source of the data for this study was the 2020 Ethiopian Ministry of Health from March up to July using multiple linear regression models. Among 468,814 total tests, 9,027 were recovered, 20,900 were confirmed cases, and 365 were deaths from coronavirus diseases in Ethiopia. Critical cases (&amp;beta;= 0.570, p= 0.006) and average temperature (&amp;beta;= &amp;minus; 35.061, p= 0.003) variables were statistically significant. Critical or serious cases significantly and positively affected the deaths from this pandemic disease, while the average temperature significantly and negatively affected the deaths from COVID-19 disease in Ethiopia.Keywords: COVID-19, predictors, multiple linear regression, Ethiopia</text>
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                <text>2020</text>
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                <text>covid-19, Ethiopia, Multiple Linear Regression, Predictors</text>
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                <text>Biotemas</text>
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              <elementText elementTextId="86806">
                <text>Universidade Federal de Santa Catarina</text>
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                <text>Public aspects of medicine</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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            <description>A name given to the resource</description>
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                <text>La Historia de una especie del patrimonio holguinero: Escobaria cubensis (Cactaceae) 'el cactus enano'. Primera parte</text>
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                <text>Alena Reyes Fornet, Elena Fornet Hernández</text>
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            <description>An account of the resource</description>
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                <text>Presenta una investigación sobre la historia taxonómica y estudios sobre la ecología del 'cactus enano de Holguín', Escobaria cubensis (Britton &amp; Rose) Hunt, 1978 desde 1909 hasta 1990, elementos importantes, para la conservación y como contribución al conocimiento de la historia del patrimonio natural holguinero, con datos históricos sobre visitas de personalidades del mundo y Holguín. Se estudiaron 37 materiales correspondientes a notas de viajes, cartas y publicaciones. Se señala la posibilidad de que el colector, J. Shafer estuvo en dos zonas de distribución. Las contribuciones al conocimiento de su ecología hasta 1990 se basaron en la observación y descripción.</text>
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                <text>2010</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Ciencias Holguín</text>
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                <text>Centro de Información y Gestión Tecnológica (CIGET) Holguín</text>
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                <text>Technology, Production management. Operations management</text>
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                <text>&lt;a href="http://www.redalyc.org/articulo.oa?id=181517919009" target="_blank" rel="noreferrer noopener"&gt;http://www.redalyc.org/articulo.oa?id=181517919009&lt;/a&gt;</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>No Effect of a Homeopathic Preparation on Neonatal Calf Diarrhoea in a Randomised Double-Blind, Placebo-Controlled Clinical Trial</text>
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                <text>Alenius S, Öhagen P, de Verdier K</text>
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                <text>A double-blind, placebo-controlled clinical trial of a homeopathic treatment of neonatal calf diarrhoea was performed using 44 calves in 12 dairy herds. Calves with spontaneously derived diarrhoea were treated with either the homeopathic remedy Podophyllum (D30) (n = 24) or a placebo (n = 20). No clinically or statistically significant difference between the 2 groups was demonstrated. Calves treated with Podophyllum had an average of 3.1 days of diarrhoea compared with 2.9 days for the placebo group. Depression, inappetence and fever were presented equally in the 2 groups. These results support the widely held opinion that scientific proof for the efficacy of veterinary homeopathy is lacking. In the European Union this implies a considerable risk for animal welfare, since in some countries priority is given to homeopathic treatments in organic farming.</text>
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                <text>2003</text>
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                <text>antibiotics, bovine, coronavirus, Cryptosporidium, Enteritis, homeopathy, medicine, organic farming, Podophyllum, rotavirus, Scour, Veterinary</text>
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                <text>DOI: 10.1186/1751-0147-44-97</text>
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                <text>Acta Veterinaria Scandinavica</text>
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                <text>BMC</text>
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                <text>Veterinary medicine</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>The Perception of COVID-19 among Italian Dentists: An Orthodontic Point of View.</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Alessandra Amato, Massimo Amato, Roberto Rongo, Stefano Martina, Mario Caggiano</text>
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                <text>COVID-19 has severely impacted dentists, who are at a great risk of infection. This study aimed to investigate if dentists are anxious about returning to their daily activities, and what the perception of the risk is for dentists and orthodontists regarding orthodontic procedures. An online questionnaire, including the Patient Health Questionnaire-4 (PHQ-4), was sent to Italian dentists during the final days of the lockdown with items about anxiety, fear, distress, perceived risk for operators, and concerns about orthodontic patients caused by working during the COVID-19 outbreak. Data were analyzed with a chi-square test and logistic regression analysis. The level of significance was set as p &lt; 0.05. A total of 349 dentists completed the survey, including 183 orthodontists. Returning to their daily work activity was a source of anxiety for 192 participants and this was associated with the level of distress (odds ratio (OR) = 3.7; p &lt; 0.001). Most of the orthodontists (67.6%) thought that they would increase the number of working hours during the week (OR = 1.8; p = 0.007). Italian dentists were mostly scared to return to their daily activities because they considered their jobs a high risk to them and their families. Dentists with an exclusive/prevailing orthodontic activity were forced to increase their working day during the week.</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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                <text>Anxiety, survey, Risk Management, dentistry, Orthodontics, COVID-19</text>
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                <text>DOI: 10.3390/ijerph17124384</text>
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            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="36085">
                <text>International Journal of Environmental Research and Public Health</text>
              </elementText>
            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="36086">
                <text>MDPI AG</text>
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            </elementTextContainer>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Could Antigen Presenting Cells Represent a Protective Element during SARS-CoV-2 Infection in Children?</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="78997">
                <text>Alessandra Bitto, Natasha Irrera, Rita Lauro, Ali  H. Eid</text>
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            <description>An account of the resource</description>
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                <text>Antigen Presenting Cells (APC) are immune cells that recognize, process, and present antigens to lymphocytes. APCs are among the earliest immune responders against an antigen. Thus, in patients with COVID-19, a disease caused by the newly reported SARS-CoV-2 virus, the role of APCs becomes increasingly important. In this paper, we dissect the role of these cells in the fight against SARS-CoV-2. Interestingly, this virus appears to cause a higher mortality among adults than children. This may suggest that the immune system, particularly APCs, of children may be different from that of adults, which may then explain differences in immune responses between these two populations, evident as different pathological outcome. However, the underlying molecular mechanisms that differentiate juvenile from other APCs are not well understood. Whether juvenile APCs are one reason why children are less susceptible to SARS-CoV-2 requires much attention. The goal of this review is to examine the role of APCs, both in adults and children. The molecular mechanisms governing APCs, especially against SARS-CoV-2, may explain the differential immune responsiveness in the two populations.</text>
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                <text>2021</text>
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                <text>covid-19, SARS-CoV-2, cytokine storm, IFN signaling, Antigen presenting cells (APC), juvenile immunity</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="79001">
                <text>10.3390/pathogens10040476</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Biotemas</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="79003">
                <text>Universidade Federal de Santa Catarina</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="79004">
                <text>Medicine</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>A compartment modeling approach to reconstruct and analyze gender and age-grouped CoViD-19 Italian data for decision-making strategies.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="77642">
                <text>Alessandra Cartocci, Gabriele Cevenini, Paolo Barbini</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="77643">
                <text>Available national public data are often too incomplete and noisy to be used directly to interpret the evolution of epidemics over time, which is essential for making timely and appropriate decisions. The use of compartment models can be a worthwhile and attractive approach to address this problem. The present study proposes a model compartmentalized by sex and age groups that allows for more complete information on the evolution of the CoViD-19 pandemic in Italy. Italian public data on CoViD-19 were pre-treated with a 7-day moving average filter to reduce noise. A time-varying susceptible-infected-recovered-deceased (SIRD) model distributed by age and sex groups was then proposed. Recovered and infected individuals distributed by groups were reconstructed through the SIRD model, which was also used to simulate and identify optimal scenarios of pandemic containment by vaccination. The simulation started from realistic initial conditions based on the SIRD model parameters, estimated from filtered and reconstructed Italian data, at different pandemic times and phases. The following three objective functions, accounting for total infections, total deaths, and total quality-adjusted life years (QALYs) lost, were minimized by optimizing the percentages of vaccinated individuals in five different age groups. The developed SIRD model clearly highlighted those pandemic phases in which younger people, who had more contacts and lower mortality, infected older people, characterized by a significantly higher mortality, especially in males. Optimizing vaccination strategies yielded different results depending on the cost function used. As expected, to reduce total deaths, the suggested strategy was to vaccinate the older age groups, whatever the baseline scenario. In contrast, for QALYs lost and total infections, the optimal vaccine solutions strongly depended on the initial pandemic conditions: during phases of high virus diffusion, the model suggested to vaccinate mainly younger groups with a higher contact rate. Because of the poor quality and insufficient availability of stratified public pandemic data, ad hoc information filtering and reconstruction procedures proved essential. The time-varying SIRD model, stratified by age and sex groups, provided insights and additional information on the dynamics of CoViD-19 infection in Italy, also supporting decision making for containment strategies such as vaccination.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="77644">
                <text>2021</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="77645">
                <text>Epidemic, covid-19, SIRD-model, decision making, Compartment modeling, Stratified analysis</text>
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            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="77646">
                <text>10.1016/j.jbi.2021.103793</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="77647">
                <text>Journal of biomedical informatics</text>
              </elementText>
            </elementTextContainer>
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  <item itemId="2088" public="1" featured="0">
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="20060">
                <text>Human coronavirus alone or in co-infection with rhinovirus C is a risk factor for severe respiratory disease and admission to the pediatric intensive care unit: A one-year study in Southeast Brazil.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="20061">
                <text>Alessandra K. Matsuno, Talita B Gagliardi, Flávia E. Paula, Luciano KS Luna, Bruna L S Jesus, Renato T. Stein, Davi C. Aragon, Ana P. C. P. Carlotti, Eurico Arruda</text>
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            <description>An account of the resource</description>
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                <text>OBJECTIVE:We aimed to assess the profile of respiratory viruses in young children hospitalized for acute lower respiratory tract infection (ALRI) and its association with disease severity, defined as need for pediatric intensive care unit (PICU) admission. DESIGN:Prospective observational cohort study. SETTING:A tertiary-care university hospital in Brazil. PATIENTS:Children younger than three years attending the pediatric emergency room with ALRI who were admitted to the hospital. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:Nasopharyngeal aspirates were collected from patients from June 1st, 2008 to May 31st, 2009within the first 48 hours of hospitalization. Nasopharyngeal aspirates were tested for 17humanrespiratory viruses by molecular and immunofluorescence based assays. Simple and multiple log-binomial regression models were constructed to assess associations of virus type with a need for PICU admission. Age, prematurity, the presence of an underlying disease and congenital heart disease were covariates. Nasopharyngeal aspirates were positive for at least one virus in 236 patients. Rhinoviruses were detected in 85.6% of samples, with a preponderance of rhinovirus C (RV-C) (61.9%). Respiratory syncytial virus was detected in 59.8% and human coronavirus (HCoV) in 11% of the samples. Co-detections of two to five viruses were found in 78% of the patients. The detection of HCoV alone (adjusted relative risk (RR) 2.18; 95% CI 1.15-4.15) or in co-infection with RV-C (adjusted RR 2.37; 95% CI 1.23-4.58) was independently associated with PICU admission. CONCLUSIONS:The detection of HCoV alone or in co-infection with RV-C was independently associated with PICU admission in young children hospitalized for ALRI.</text>
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                <text>2019</text>
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            <name>Identifier</name>
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                <text>DOI: 10.1371/journal.pone.0217744</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="20065">
                <text>PLoS ONE</text>
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              <elementText elementTextId="20066">
                <text>Public Library of Science (PLoS)</text>
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                <text>Science, Medicine</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                <elementText elementTextId="88122">
                  <text>Dominio científico: Agricultura sostenible</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Uso de hidrolizados de pescado en la acuicultura: una revisión de algunos resultados beneficiosos en dietas acuícolas</text>
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            <name>Creator</name>
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              <elementText elementTextId="206334">
                <text>Alessandra L. Cardoza Ramirez, Mariafernanda G. Guerra Espinoza, Alfredo R. Palomino Ramos</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="206335">
                <text>Las industrias pesqueras y de acuicultura generan, cada año, un conjunto de residuos o desechos que incluyen piel, cabeza, vísceras, recortes y espinazos, representando más del 60% en volumen productivo. Estos residuos tienen altos contenidos de proteínas, y normalmente son procesados en productos de bajo valor comercial, como alimentos para animales, harina de residuos y fertilizantes. En los últimos años, se han venido desarrollando tecnologías para el aprovechamiento de éstos residuos y convertirlos en bioproductos de mayor valor agregado, como son los hidrolizados de proteínas, con interesantes aplicaciones en la alimentación animal. Los hidrolizados proteicos de pescado son productos obtenidos de la degradación enzimática o química de las proteínas de pescado en péptidos más pequeños, aminoácidos libres y nucleótidos, obteniéndose un alto contenido proteico con buen balance de aminoácidos, alta digestibilidad y mejor aprovechamiento de sus nutrientes. La inclusión de éstos hidrolizados en los alimentos acuícolas puede mejorar el crecimiento y la eficiencia alimentaria de los organismos acuáticos en cultivo. Este artículo presenta una revisión sobre investigaciones de la inclusión de hidrolizados proteicos de pescado en dietas experimentales para peces, crustáceos, moluscos y algas, y los efectos en los desempeños productivos, en los últimos veinte años.</text>
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            <name>Date</name>
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                <text>2021</text>
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            <name>Subject</name>
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                <text>organismos acuáticos; desempeño productivo; eficiencia alimentaria; tasa de crecimiento</text>
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            <name>Identifier</name>
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              <elementText elementTextId="206338">
                <text>10.17268/manglar.2021.029</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="206339">
                <text>Manglar</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="206340">
                <text>Universidad Nacional de Tumbes</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="206341">
                <text>Agriculture (General), Plant culture, Animal culture, Ecology</text>
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          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="206342">
                <text>&lt;a href="https://erp.untumbes.edu.pe/revistas/index.php/manglar/article/view/246" target="_blank" rel="noreferrer noopener"&gt;https://erp.untumbes.edu.pe/revistas/index.php/manglar/article/view/246&lt;/a&gt;</text>
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