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Small Molecule Inhibitors of CRM1
The transport through the nuclear pore complex is used by cancer cells to evade tumor-suppressive mechanisms. Several tumor-suppressors have been shown to be excluded from the cell nucleus in cancer cells by the nuclear export receptor CRM1 and…
Position: 18618 (16 views)
Intensive Care Risk Estimation in COVID-19 Pneumonia Based on Clinical and Imaging Parameters: Experiences from the Munich Cohort
The evolving dynamics of coronavirus disease 2019 (COVID-19) and the increasing infection numbers require diagnostic tools to identify patients at high risk for a severe disease course. Here we evaluate clinical and imaging parameters for estimating…
Position: 5910 (32 views)
Vascular Inflammation Is Associated with Loss of Aquaporin 1 Expression on Endothelial Cells and Increased Fluid Leakage in SARS-CoV-2 Infected Golden Syrian Hamsters
Vascular changes represent a characteristic feature of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leading to a breakdown of the vascular barrier and subsequent edema formation. The aim of this study was to provide a…
Position: 8041 (28 views)
Role of Cell Adhesion Molecules for Prognosis of Disease Development of Patients With and Without COVID-19 in the Emergency Department.
Position: 17004 (18 views)
Aplicaciones de la teoría del control a la economía
La teoría del control se ha desarrollado y aplicado ampliamente en muchas áreas de la Ingeniería. En los últimos años se ha venido aplicando también, en campos diferentes a los de la ingeniería como por ejemplo en Ecología, Economía, diversas áreas…
Position: 3113 (43 views)
A Single-Center Experience with Lung Transplants During the COVID-19 Pandemic.
BACKGROUND This single-center study analyzed distinctions between lung transplants performed in the Department of Cardiac and Vascular surgery of the University Clinical Center in Gdańsk, Poland before and during the COVID-19 pandemic. MATERIAL AND…
Position: 19227 (15 views)
Can Stem Cells Beat COVID-19: Advancing Stem Cells and Extracellular Vesicles Toward Mainstream Medicine for Lung Injuries Associated With SARS-CoV-2 Infections
A number of medicines are currently under investigation for the treatment of COVID-19 disease including anti-viral, anti-malarial, and anti-inflammatory agents. While these treatments can improve patient's recovery and survival, these therapeutic…
Position: 12095 (23 views)
Effect of Reading Rehabilitation for Age-Related Macular Degeneration on Cognitive Functioning: Protocol for a Nonrandomized Pre-Post Intervention Study
BackgroundAge-related vision impairments and dementia both become more prevalent with increasing age. Research into the mechanisms of these conditions has proposed that some of their causes (eg, macular degeneration/glaucoma and Alzheimer’s disease)…
Position: 12095 (23 views)
The use of the new base gel in Hospital Recipe’s practice.
Semi-solid preparations for application to skin - including ointments - are one of the most commonly prescribed by doctors as well as made in pharmacies nowadays. Due to the registration of new raw materials (for compounding) in the form of gels in…
Position: 17004 (18 views)
Social, ethical and behavioural aspects of COVID-19 [version 2; peer review: 2 approved]
Introduction: Vaccines and drugs for the treatment and prevention of COVID-19 require robust evidence generated from clinical trials before they can be used. Decisions on how to apply non-pharmaceutical interventions such as quarantine,…
Position: 15153 (20 views)