https://www.socictopen.socict.org/files/original/c610f15de4a8bddddd1e797691af2bda.pdf 08cc59ee42440175c1c24602d2f44cef Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances [version 1; referees: 3 approved] Creator An entity primarily responsible for making the resource Stephen A. Goldstein, Susan R. Weiss Description An account of the resource Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV research has progressed in several parallel and complementary directions. This review will focus on three particular areas: the origins and evolution of MERS-CoV, the challenges and achievements in the development of MERS-CoV animal models, and our understanding of how novel proteins unique to MERS-CoV counter the host immune response. The origins of MERS-CoV, likely in African bats, are increasingly clear, although important questions remain about the establishment of dromedary camels as a reservoir seeding human outbreaks. Likewise, there have been important advances in the development of animal models, and both non-human primate and mouse models that seem to recapitulate human disease are now available. How MERS-CoV evades and inhibits the host innate immune response remains less clear. Although several studies have identified MERS-CoV proteins as innate immune antagonists, little of this work has been conducted using live virus under conditions of actual infection, but rather with ectopically expressed proteins. Accordingly, considerable space remains for major contributions to understanding unique ways in which MERS-CoV interacts with and modulates the host response. Collectively, these areas have seen significant advances over the last several years but continue to offer exciting opportunities for discovery. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource epidemiology, virology, immune response, Animal Genetics, Medical Microbiology, Tropical & Travel-Associated Diseases, Viral Infections (without HIV), Genetics of the Immune System, Immunity to Infections, Cellular Microbiology & Pathogenesis, Microbial Evolution & Genomics, Leukocyte Signaling & Gene Expression, Nosocomial & Healthcare-Associated Infections Identifier An unambiguous reference to the resource within a given context 10.12688/f1000research.11827.1 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine