Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism
Middle East respiratory syndrome coronavirus, severe acute respiratory syndrome coronavirus, coronavirus spike glycoprotein, vaccine platforms, correlates of immunity, animal models
Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.