Genetic lesions within the 3a gene of SARS-CoV

Genetic lesions within the 3a gene of SARS-CoV

Lim Seng, Shen Shuo, Chou Chih-Fong, Fielding Burtram C, Barkham Timothy, Tan Timothy HP, Hong Wanjin, Tan Yee-Joo

Abstract A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.

2005

DOI: 10.1186/1743-422X-2-51

Virology Journal

BMC

Infectious and parasitic diseases

EN