Antiviral activity of itraconazole against type I feline coronavirus infection

Antiviral activity of itraconazole against type I feline coronavirus infection

Tomomi Takano, Misuzu Akiyama, Tomoyoshi Doki, Tsutomu Hohdatsu

Abstract Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70–90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.

2019

DOI: 10.1186/s13567-019-0625-3

Veterinary Research

BMC

Veterinary medicine

EN