Bat Flight and Zoonotic Viruses

Bat Flight and Zoonotic Viruses

Thomas J. O’Shea, Paul M. Cryan, Andrew A. Cunningham, Anthony R. Fooks, David T.S. Hayman, Angela D. Luis, Alison J Peel, Raina K. Plowright, James L.N. Wood

Bats are sources of high viral diversity and high-profile zoonotic viruses worldwide. Although apparently not pathogenic in their reservoir hosts, some viruses from bats severely affect other mammals, including humans. Examples include severe acute respiratory syndrome coronaviruses, Ebola and Marburg viruses, and Nipah and Hendra viruses. Factors underlying high viral diversity in bats are the subject of speculation. We hypothesize that flight, a factor common to all bats but to no other mammals, provides an intensive selective force for coexistence with viral parasites through a daily cycle that elevates metabolism and body temperature analogous to the febrile response in other mammals. On an evolutionary scale, this host–virus interaction might have resulted in the large diversity of zoonotic viruses in bats, possibly through bat viruses adapting to be more tolerant of the fever response and less virulent to their natural hosts.

2014

bats, body temperature, Chiroptera, emerging zoonotic viruses, Fever, flight

DOI: 10.3201/eid2005.130539

Emerging Infectious Diseases

Centers for Disease Control and Prevention

Infectious and parasitic diseases, Medicine

EN