Domestic Pig Unlikely Reservoir for MERS-CoV

Domestic Pig Unlikely Reservoir for MERS-CoV

Emmie de Wit, Friederike Feldmann, Eva Horne, Cynthia Martellaro, Elaine Haddock, Trenton Bushmaker, Kyle Rosenke, Atsushi Okumura, Rebecca Rosenke, Greg Saturday, Dana Scott, Heinz Feldmann

We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a reservoir in nature.

2017

Middle East respiratory syndrome coronavirus, MERS-CoV, animal models, domestic pig, dipeptidyl peptidase-4, DPP4

DOI: 10.3201/eid2306.170096

Emerging Infectious Diseases

Centers for Disease Control and Prevention

Infectious and parasitic diseases, Medicine

EN