https://www.socictopen.socict.org/files/original/c1d6585ff1b44a0930333dba3e9f6453.pdf e89455d83888e6f9e5ea9f9d00af8acc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-<i>O</i>-Amide Hesperetin Derivatives Creator An entity primarily responsible for making the resource Yilong Zhang, Yan Zheng, Wen Shi, Yahui Guo, Tao Xu, Zeng Li, Cheng Huang, Jun Li Description An account of the resource To develop new anti-inflammatory agents, a series of 7-O-amide hesperetin derivatives was designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. All compounds showed inhibitory effect on LPS-induced NO production. Among them, 7-O-(2-(Propylamino)-2-oxoethyl)hesperetin (4d) and 7-O-(2-(Cyclopentylamino)-2-oxoethyl)hesperetin (4k) with hydrophobic side chains exhibited the most potent NO inhibitory activity (IC50 = 19.32 and 16.63 &#956;M, respectively), showing stronger inhibitory effect on the production of pro- inflammatory cytokines tumor necrosis factor (TNF-&#945;), interleukin-6 (IL-6) and interleukin-1&#946; (IL-1&#946;) than indomethacin and celecoxib at 10 &#956;M. The structure-activity relationships (SARs) suggested that the 7-O-amide unit was buried in a medium-sized hydrophobic cavity of the bound receptor. Furthermore, compound 4d could also significantly suppress the expression of inducible nitric oxide synthase enzymes (iNOS) and cyclooxygenase-2 (COX-2), through the nuclear factor-kappa B (NF-&#954;B) signaling pathway. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource hesperetin derivatives, Synthesis, Inflammatory, NF-κB, structure-activity relationships Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/molecules24203663 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Language A language of the resource EN