Acute phase response in bovine coronavirus positive post-weaned calves with diarrhea

Acute phase response in bovine coronavirus positive post-weaned calves with diarrhea

Jeong-Byoung Chae, Jin-ho Park, Suk-Han Jung, Jin Hee Kang, Joon-Seok Chae, Kyoung-Seong Choi

Abstract Bovine coronavirus (BCoV) is associated with severe diarrhea in calves, winter dysentery in adult cattle, and respiratory diseases in cattle of all ages. This study aimed to investigate the relationship between white blood cell counts and haptoglobin (Hp) and serum amyloid A (SAA) levels in post-weaned calves with diarrhea caused by BCoV and those that recovered from diarrhea. Blood and fecal samples were collected twice from the same animals; 17 post-weaned calves with diarrhea (first) and 15 post-weaned calves that recovered from diarrhea (second). Real-time polymerase chain reaction revealed that all 17 fecal samples from post-weaned calves with diarrhea and one out of 15 from diarrhea-recovered calves were positive for BCoV and negative for Cryptosporidium spp., Escherichia coli K99, Salmonella spp., bovine rotavirus, and bovine viral diarrhea virus. No Eimeria oocysts were detected using the flotation method. In comparison with post-weaned calves with diarrhea, in diarrhea-recovered calves, the lymphocyte count was significantly higher (P = 0.018), and the monocyte count was significantly lower (P = 0.001); however, the number of monocytes was still high. Post-weaned calves with diarrhea had a significantly higher Hp concentration (P 

2019

Bovine coronavirus, Haptoglobin, Serum amyloid A

DOI: 10.1186/s13028-019-0471-3

Acta Veterinaria Scandinavica

BMC

Veterinary medicine

EN