https://www.socictopen.socict.org/files/original/3a21a59583446818ae7d23de5b5590b5.pdf c567dc35c93215b99ad9750264cd4d22 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Enhancement of anti-murine colon cancer immunity by fusion of a SARS fragment to a low-immunogenic carcinoembryonic antigen Creator An entity primarily responsible for making the resource Lin Chen-Si, Kao Shih-Han, CHEN Yu-cheng, Li Chi-Han, Hsieh Yuan-Ting, Yang Shang-Chih, Wu Chang-Jer, Lee Ru-Ping, Liao Kuang-Wen Description An account of the resource Abstract Background It is widely understood that tumor cells express tumor-associated antigens (TAAs), of which many are usually in low immunogenicity; for example, carcinoembryonic antigen (CEA) is specifically expressed on human colon cancer cells and is viewed as a low-immunogenic TAA. How to activate host immunity against specific TAAs and to suppress tumor growth therefore becomes important in cancer therapy development. Results To enhance the immune efficiency of CEA in mice that received, we fused a partial CEA gene with exogenous SARS-CoV fragments. Oral vaccination of an attenuated Salmonella typhimurium strain transformed with plasmids encoding CEA-SARS-CoV fusion gene into BALB/c mice elicited significant increases in TNF-α and IL-10 in the serum. In addition, a smaller tumor volume was observed in CT26/CEA-bearing mice who received CEA-SARS-CoV gene therapy in comparison with those administered CEA alone. Conclusion The administration of fusing CEA-SARS-CoV fragments may provide a promising strategy for strengthening the anti-tumor efficacy against low-immunogenic endogenous tumor antigens. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource immunotherapy, tumor-derived peptide, tumor vaccine, Low immunogenicity Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1480-9222-14-2 Source A related resource from which the described resource is derived Biological Procedures Online Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Medicine (General) Language A language of the resource EN