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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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              <text>Emerging Treatment and Prevention Strategies against COVID-19: A Brief Update</text>
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              <text>Ravikant Kumar, Ashis K. Jha, Mahes K. Goenka, Vishwa M. Dayal</text>
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              <text>Patients with novel coronavirus disease 2019 (COVID-19) are at significantly increased risk for mortality and morbidity. Current management remains supportive care, ranging from symptomatic outpatient management to full–intensive care support, including intravenous fluids, invasive, and non-invasive oxygen supplementation. In patients with septic shock, treatment with antibiotics and vasopressors are recommended to keep mean arterial pressure (MAP) ≥ 65 mm Hg and lactate &lt; 2 mmol/L. Because of the lack of effectiveness and possible adverse effects, routine corticosteroids should be avoided unless they are indicated for another reason (exacerbation of asthma or chronic obstructive pulmonary disease [COPD], and septic shock in whom fluids and vasopressors do not restore hemodynamic stability). There is currently no sufficient evidence of efficacy of hydroxychloroquine/chloroquine, remdesivir, and other antivirals in the treatment or prevention of COVID-19. Limited evidence shows that COVID-19 convalescent plasma can be used as a treatment of COVID-19 without the occurrence of severe adverse events. Drug regulatory agencies granted an emergency-use authorization of chloroquine/hydroxychloroquine and remdesivir to treat patients when a clinical trial is not available or participation is not feasible. Chloroquine and hydroxychloroquine are associated with QT interval prolongation and life-threatening cardiac arrhythmia in patients with pre-existing cardiovascular disease. Guidelines are issued for use of convalescent plasma in patients with serious or immediately life-threatening COVID-19. Data from several ongoing randomized controlled trials will provide further evidence regarding the safety and efficacy of these drugs for the treatment of COVID-19.</text>
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              <text>2020</text>
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              <text>vaccines, chloroquine, World Health Organization, hydroxychloroquine, convalescent plasma, remdesivir, Severe Acute Respiratory Syndrome Coronavirus 2, novel coronavirus disease 2019</text>
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              <text>DOI: 10.1055/s-0040-1712547</text>
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              <text>Journal of Digestive Endoscopy</text>
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          <name>Publisher</name>
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              <text>Thieme Publishers</text>
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              <text>Diseases of the digestive system. Gastroenterology</text>
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