Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19

Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19

Fen Wang, Yan Yang, Shujun Zhang, Kun Dong, Xiaoli Shi, Yongli Yan, Xue-Feng Yu, Huihui Ren

Abstract Background The triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. This study aims to evaluate the association of the TyG index with the severity and mortality of coronavirus disease 2019 (COVID-19). Methods The study included a cohort of 151 patients with COVID-19 admitted in a tertiary teaching hospital in Wuhan. Regression models were used to investigate the association between TyG with severity and mortality of COVID-19. Results In this cohort, 39 (25.8%) patients had diabetes, 62 (41.1%) patients were severe cases, while 33 (22.0%) patients died in hospital. The TyG index levels were significantly higher in the severe cases and death group (mild vs. severe 8.7 ± 0.6 vs. 9.2 ± 0.6, P 

2020

Mortality, Severity, TyG index, COVID-19

DOI: 10.1186/s12933-020-01035-2

Cardiovascular Diabetology

BMC

Diseases of the circulatory (Cardiovascular) system