https://www.socictopen.socict.org/files/original/3a7c993b73b661ca67eb39aa4c67e9a7.pdf 75a2b2f6aa9f1a3d34d3e0bdc581206d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs Creator An entity primarily responsible for making the resource Lawrence W. Stanton, Bing Lim, Eng Eong Ooi, Ai Ee Ling, Hwee Cheng Tan, Chin-Yo Lin, Emily L.C. Tan Description An account of the resource Severe acute respiratory syndrome (SARS) is an infectious disease caused by a newly identified human coronavirus (SARS-CoV). Currently, no effective drug exists to treat SARS-CoV infection. In this study, we investigated whether a panel of commercially available antiviral drugs exhibit in vitro anti–SARS-CoV activity. A drug-screening assay that scores for virus-induced cytopathic effects on cultured cells was used. Tested were 19 clinically approved compounds from several major antiviral pharmacologic classes: nucleoside analogs, interferons, protease inhibitors, reverse transcriptase inhibitors, and neuraminidase inhibitors. Complete inhibition of cytopathic effects of SARS-CoV in culture was observed for interferon subtypes, β-1b, α-n1, α-n3, and human leukocyte interferon α. These findings support clinical testing of approved interferons for the treatment of SARS. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource antiviral, in vitro, antivirals, Antiviral Agents, agents, antiviral drugs Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1004.030458 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine