Animal models for the risk assessment of viral pandemic potential

Animal models for the risk assessment of viral pandemic potential

Jin-Il Kim, Man-Seong Park, Joon-Yong Bae, Mee Sook Park

Abstract Pandemics affect human lives severely and globally. Experience predicts that there will be a pandemic for sure although the time is unknown. When a viral epidemic breaks out, assessing its pandemic risk is an important part of the process that characterizes genomic property, viral pathogenicity, transmission in animal model, and so forth. In this review, we intend to figure out how a pandemic may occur by looking into the past influenza pandemic events. We discuss interpretations of the experimental evidences resulted from animal model studies and extend implications of viral pandemic potentials and ingredients to emerging viral epidemics. Focusing on the pandemic potential of viral infectious diseases, we suggest what should be assessed to prevent global catastrophes from influenza virus, Middle East respiratory syndrome coronavirus, dengue and Zika viruses.

2020

zoonosis, virus, Transmission, pathogenicity, Animal model, Pandemic

DOI: 10.1186/s42826-020-00040-6

Laboratory Animal Research

BMC

Biology (General), Medicine (General)