The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China

The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China

Jing Gao, Hua Liu, Xiaojun Wang, Wei-dong Hu, Xia Han, Jun-qiang Liu, Chuanxing Li, Heng-Jun Wen

Abstract The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been considered as a criterion for ending antiviral treatment. We compared the two COVID-19 cases with similar backgrounds and CT image repeated intervals under treatment. Our report highlighted the unsynchronized expression in the changes of CT image and nucleic acid detection in COVID-19, and lasting positive nucleic acid test result in patients recovered from pneumonia. It may be contributed to recognize the disease and improve prevention.

2020

CT image, Nucleic acid detection, SARS-CoV-2, COVID-19

DOI: 10.1186/s12931-020-01363-7

Respiratory Research

BMC

Diseases of the respiratory system