Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies
Título
Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies
Autor
Elmoubasher A. B. A. Farag, Chantal B. E. M. Reusken, Bart L. Haagmans, Marion P. G. Koopmans, Wentao Li, Wan Beom Park, Myoung-don Oh, Corine H. GeurtsvanKessel, Nisreen M.A. Okba, Ivy Widjaja, Mohammed Al-Hajri, Berend-Jan Bosch
Descripción
We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.
Fecha
2020
Materia
neutralization, Antibodies, Lumazine synthase, MERS, Middle East respiratory syndrome coronavirus, hemagglutination
Identificador
DOI: 10.3201/eid2605.190921
Fuente
Emerging Infectious Diseases
Editor
Centers for Disease Control and Prevention
Cobertura
Infectious and parasitic diseases, Medicine
Archivos
Colección
Citación
Elmoubasher A. B. A. Farag, Chantal B. E. M. Reusken, Bart L. Haagmans, Marion P. G. Koopmans, Wentao Li, Wan Beom Park, Myoung-don Oh, Corine H. GeurtsvanKessel, Nisreen M.A. Okba, Ivy Widjaja, Mohammed Al-Hajri, Berend-Jan Bosch, “Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies,” SOCICT Open, consulta 18 de abril de 2026, https://www.socictopen.socict.org/items/show/3176.
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