Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection

Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection

Yue Wu, Yu Gu, Jianguo Guo, Qi Kong, Zhiguang Xiang, Fei Geng

Abstract Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.

2020

lung cancer, ACE2, TMPRSS2, SARS-CoV-2, COVID-19

DOI: 10.1186/s12943-020-01209-2

Molecular Cancer

BMC

Neoplasms. Tumors. Oncology. Including cancer and carcinogens