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                <text>Dominio científico: Coronavirus</text>
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              <text>A brief note on randomized controlled trials and compassionate/off-label use of drugs in the early phases of the COVID-19 pandemic</text>
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              <text>Paolo Pelosi, Matteo Bassetti, Antonio Vena, Chiara Robba, Daniele Roberto Giacobbe</text>
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              <text>Randomized controlled trials (RCTs) are the best way to find effective and acceptable safe treatments for COVID-19 and any possible future outbreak. However, caution is needed when comparing the number of participants in RCTs with that of patients with COVID-19 treated with compassionate and/or off-label drugs to support the hypothesis that the latter are preferred by clinicians as an alternative to the former.</text>
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              <text>DOI: 10.7573/dic.2020-5-2</text>
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              <text>Drugs in Context</text>
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              <text>BioExcel Publishing Ltd</text>
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              <text>Therapeutics. Pharmacology</text>
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