https://www.socictopen.socict.org/files/original/0e7f86d98868775ecb8d531093ae7153.pdf 988389f8f02374801ca61ccd9bd6b57c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Molecular Characterization and Amino Acid Homology of Nucleocapsid (N) Protein in SARS-CoV-1, SARSCoV-2, MERS-CoV, and Bat Coronavirus Creator An entity primarily responsible for making the resource Kannan Subbaram, Hemalatha Kannan, Shantani Kannan, Sheeza Ali Description An account of the resource Coronavirus disease – 2019 (COVID-19) pandemic, due to severe acute respiratory syndrome–coronavirus-2 (SARS-CoV-2), is posing a severe bio threat to the entire world. Nucleocapsids of SARSCoV-2 and the related viruses were studied for gene and amino acid sequence homologies. In this study,we established similarities and differences in nucleocapsids in SARS-CoV-2, severe acute respiratorysyndrome – coronavirus-1 (SARS-CoV-1), bat coronavirus (bat-CoV) and Middle East respiratorysyndrome - coronavirus (MERS-CoV). We conducted a detailed analysis of the nucleocapsid proteinamino acid and gene sequence encoding it, found in various coronavirus strains. After thoroughlyscreening the different nucleocapsids, we observed a close molecular homology between SARSCoV-1 and SARS-CoV-2. More than 95% sequence similarity was observed between the two SARSCoV strains. Bat-CoV and SARS-CoV-2 showed 92% sequence similarity. MERS-CoV and SARS-CoV-2nucleocapsid analysis indicated only 65% identity. Molecular characterization of nucleocapsids fromvarious coronaviruses revealed that SARS-CoV 2 is more related to SARS-CoV 1 and bat-CoV. SARS-CoV2 exhibited less resemblance with MERS-CoV. SARS-CoV 2 showed less similarity to MERS-CoV. Thus,either SARS-CoV-1 or bat-CoV may be the source of SARS-CoV-2 evolution. Moreover, the existingdifferences in nucleocapsid molecular structures in SARS-CoV-2 make this virus more virulent andhighly infectious, which means that the non-identical SARS-CoV-2 genes (which are absent in SARSCoV-1 and bat-CoV) are responsible for COVID-19 severity. We observed that SARS-CoV-2 nucleocapsidfrom different locations varied in amino acid sequences. This revealed that there are many SARS-CoV-2subtypes/subsets currently circulating globally. This study will help to develop antiviral vaccine anddrugs, study viral replication and immunopathogenesis, and synthesize monoclonal antibodies thatcan be used for precise COVID-19 diagnosis, without false-positive/false-negative results. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Virulence, correlation, MERS, SARS-CoV-2, COVID-19, nucleocapsid N protein, SARS-CoV-1, bat-cov Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.13 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology