https://www.socictopen.socict.org/files/original/874b0cf54b401abd896011ce772a944a.pdf e7eba65cc4d885b1285dbf0faf7ca202 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Immune Status of COVID-19 Patients with Reference to SARS and MERS Creator An entity primarily responsible for making the resource Barani Karikalan, Hari Kumar Darnal Description An account of the resource During this global pandemic of COVID-19 infection, it became well known that morbidity and mortalityis especially high at the extreme of life especially in certain racial or ethnic groups like Americansand Africans. This is presumed due to low immunity associated with other comorbid conditions likediabetes, hypertension, cardiovascular disease, obesity and metabolic syndrome. But the informationavailable on the immune status of COVID-19 patients is limited. Attempts must be made to enhanceour understanding of the immune status of COVID-19 patients by revisiting our knowledge on theimmune mechanisms of already known coronaviruses such as SARS-CoV and MERS-CoV. Early elevationof the serum levels of pro-inflammatory cytokines observed in SARS and MERS infection suggests apossible same type of cytokine storm-mediated lung damage in COVID-19 patients too. Dysregulationof interferon-1 response and downstream cascade in initial innate immune response at virus entrypoint has been related to lethal pneumonia in COVID-19 patients. Adaptive response of increasedCD8+ levels in COVID-19 patients seems to be useful in mild cases where it causes deterioratingeffects in progressed severe disease patients resulting in destruction of type 2 pneumocytes henceinability to regenerate the alveolar epithelium. A phenomenon called cytokine storm activates violentimmunological reactions in the lung tissue resulting in ARDS followed by multiple organ systemdamages in COVID-19 patients. Several immune evading mechanisms are thought to be employed bysevere respiratory syndrome virus-2 (SARS-CoV-2) that might have resulted in its extremely increasedcontagiousness probably related with its frequent RNA mutations. Failure to develop adequate viruslimiting immune reactions by some cured patients warrant monitoring of all recovered patients. Thisrapid mini review is aimed to enhance our knowledge of the immune status of COVID-19 infectedpatients with reference to SARS-CoV and MERS-CoV. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, MERS-CoV, Immune status, SARS-CoV, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.18 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology