A Mini-Review on Cell Cycle Regulation of Coronavirus Infection

A Mini-Review on Cell Cycle Regulation of Coronavirus Infection

Li Feng, Mingjun Su, Shanshan Qi, Dongbo Sun, Yaping Chen, Da Shi

Coronaviruses are widespread in nature and infect humans, mammals and poultry. They cause harm to humans and animals. Virus-mediated cell cycle arrest is an essential strategy for viral survival and proliferation in the host cells. A clarification system of the mechanisms of virus-induced cell cycle arrest is highly desirable to promote the development of antiviral therapies. In this review, molecular mechanisms of coronavirus-induced cell cycle arrest were systematically summarized. Moreover, the common features of coronavirus-mediated cell cycle arrest were discussed. This review will provide a theoretical basis for further studies on the infection mechanisms and prevention of coronaviruses.

2020

coronavirus, Nucleocapsid protein, p53, cell cycle arrest, cyclin-CDK complex

10.3389/fvets.2020.586826

Epidemiology and Health

Korean Society of Epidemiology

Veterinary medicine