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              <text>Nitenpyram analogues with 1,4-dihydropyridine fixed cis-configuration:synthesis,insecticidal activities and molecular docking studies</text>
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              <text>XUE Sijia, PANG Chuncheng, CHEN Yanxia, LIU Tianyan</text>
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              <text>A novel series of Nitenpyram analogues(Ia-Ij) with 1,4-dihydropyridine fixed cis-configuration were designed and synthesized.Preliminary bioassays showed that most of them exhibited good insecticidal activities against Aphis medicagini and Brown rice planthopper at 500 mg/L and 100 mg/L.The analogue Ij afforded the best activity in vitro,that had 100% mortality at 4 mg/L against Brown rice planthopper and Aphis medicagin.In addition,the molecular docking simulations revealed that the structural uniqueness of these analogues may lead to a unique molecular recognition and binding mode,and the results explained the SARs observed in vitro, which shed light on the novel insecticidal mechanism of these novel nitenpyam analogues.</text>
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              <text>2013</text>
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              <text>cis-Nitenpyram analogue, 1, 4-Dihydropyridine, Synthesis, insecticidal acvitity, molecular docking</text>
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              <text>Journal of Shanghai Normal University (Natural Sciences)</text>
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              <text>Academic Journals Center of Shanghai Normal University</text>
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              <text>Science (General)</text>
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              <text>EN, ZH</text>
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