N-Pyrrylarylsulfones with High Therapeutic Potential

N-Pyrrylarylsulfones with High Therapeutic Potential

Valeria Famiglini, Sabrina Castellano, Romano Silvestri

This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure–activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents.

2017

sulfonamide, heterocycle, polycyclic compound, therapeutic agent

DOI: 10.3390/molecules22030434

Molecules

MDPI AG

Organic chemistry

EN