Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions

Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions

Makoto Ujike, Fumihiro Taguchi

The envelopes of coronaviruses (CoVs) contain primarily three proteins; the two major glycoproteins spike (S) and membrane (M), and envelope (E), a non-glycosylated protein. Unlike other enveloped viruses, CoVs bud and assemble at the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC). For efficient virion assembly, these proteins must be targeted to the budding site and to interact with each other or the ribonucleoprotein. Thus, the efficient incorporation of viral envelope proteins into CoV virions depends on protein trafficking and protein–protein interactions near the ERGIC. The goal of this review is to summarize recent findings on the mechanism of incorporation of the M and S glycoproteins into the CoV virion, focusing on protein trafficking and protein–protein interactions.

2015

coronavirus, Membrane protein, spike protein, assembly, Protein trafficking, intracellular retention signal, protein interactions

DOI: 10.3390/v7041700

Viruses

MDPI AG

Microbiology

EN